Pearls & Perspectives: From Pediatrics to Bladder Cancer Innovation, with Katherine Chan, MD, MPH

Pearls & Perspectives: From Pediatrics to Bladder Cancer Innovation, with Katherine Chan, MD, MPH

In this episode of Pearls & Perspectives, host Amy Pearlman, MD, welcomes Katherine Chan, MD, MPH, a pediatric urologist and former vice chair of research at University of North Carolina School of Medicine in Chapel Hill, to discuss her unexpected yet purposeful transition into the world of bladder cancer drug development.

Chan shares how her passion for research and desire to impact patients on a broader scale led her from academia to industry. She highlights the surprising rigor behind industry-sponsored clinical trials and the extensive collaboration required to run large global studies—dispelling common misconceptions about bias and scientific quality.

Now part of enGene, Chan describes her role in developing detalimogene voraplasmid, a nonviral gene therapy for non–muscle invasive bladder cancer (NMIBC). Unlike viral-based agents, this therapy offers easier handling, storage, and redosing, making it more practical for community urologists. Currently being studied in the global LEGEND trial (NCT04752722), the agent targets BCG-unresponsive NMIBC using a dual mechanism that activates both innate and adaptive immunity.

The conversation explores the broader challenges in NMIBC research, including trial recruitment, tumor heterogeneity, and the growing need for collaboration between academia, community practice, and industry. Chan also emphasizes the importance of visibility and networking—particularly through platforms like LinkedIn—for urologists interested in becoming key opinion leaders or transitioning to industry roles.

Looking ahead, Chan sees artificial intelligence and sub-specialized “centers of excellence” as shaping the future of bladder cancer care. Her key message: This is an unprecedentedly exciting time in bladder cancer, with new, patient-friendly therapies on the horizon. For patients, she underscores one takeaway—there are more options than ever before, and hope is stronger than ever.

Chapters
1:30 How a pediatric urologist gets into the bladder cancer space
12:04 How to become a key opinion leader
19:01 The NMIBC treatment landscape
25:55 Naming detalimogene voraplasmid
31:09 Where enGene stands in the clinical trial process
37:21 Implications of treatment for community urologists

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The Expert APProach: Advancing APP Leadership and Expertise in Urology, With Susanne Quallich, PhD, ANP-BC, NP-C

The Expert APProach: Advancing APP Leadership and Expertise in Urology, With Susanne Quallich, PhD, ANP-BC, NP-C

Susanne Quallich, PhD, ANP-BC, NP-C, discusses APP leadership, specialization, professional growth, and expanding the role of APPs in urology.

20 Elo 28min

Pearls & Perspectives: Patient Expectations, Physician Autonomy, and Life Beyond Surgery, With Andrew T. Cohen, MD, FACS

Pearls & Perspectives: Patient Expectations, Physician Autonomy, and Life Beyond Surgery, With Andrew T. Cohen, MD, FACS

In this episode of Pearls & Perspectives, host Amy Pearlman, MD, and plastic surgeon Andrew T. Cohen, MD, FACS, discuss managing patient expectations and the importance of cultivating balance outside ...

12 Elo 39min

The UroOnc Minute: Navigating BCG Maintenance Therapy in NMIBC, With Mark D. Tyson, II, MD, MPH

The UroOnc Minute: Navigating BCG Maintenance Therapy in NMIBC, With Mark D. Tyson, II, MD, MPH

In this episode of The UroOnc Minute, Mark D. Tyson, II, MD, MPH, joins host Adam Weiner, MD, to discuss the importance of BCG maintenance therapy in NMIBC and share strategies for navigating treatmen...

12 Elo 13min

Pearls & Perspectives: Wearable Technology and the Future of Sexual Health, With Elliot Justin, MD

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Host Amy Pearlman, MD, and guests Larry Lipshultz, MD, and Elliot Justin, MD, explore the potential of wearable technology to advance the diagnosis, monitoring, and optimization of sexual health for b...

12 Elo 15min

Pearls & Perspectives: From Prostate Cancer Diagnosis to Patient Advocacy, with Gabe Canales

Pearls & Perspectives: From Prostate Cancer Diagnosis to Patient Advocacy, with Gabe Canales

In this episode of Pearls & Perspectives, host Amy Pearlman, MD, is joined by male reproductive specialist Larry Lipshultz, MD, and patient advocate Gabe Canales for a candid conversation about prosta...

12 Elo 15min

The UroOnc Minute: Optimizing Patient Follow-Up in Urologic Oncology, With Jason Hafron, MD

The UroOnc Minute: Optimizing Patient Follow-Up in Urologic Oncology, With Jason Hafron, MD

In this episode of The UroOnc Minute, host Adam Weiner, MD, is joined by Jason Hafron, MD, to discuss how data-driven pathways and patient follow-up systems can improve quality and outcomes in urologi...

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Pearls & Perspectives: Understanding the Long-Term Health Effects of Military Exposures, With Shane Kronstedt, MD

Pearls & Perspectives: Understanding the Long-Term Health Effects of Military Exposures, With Shane Kronstedt, MD

Host Amy Pearlman, MD, and Larry Lipshultz, MD, speak with Shane Kronstedt, MD, about research on the long-term urologic effects of military exposures and how these findings may help improve care for ...

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First Assist: Early Cystectomy in Non–Muscle Invasive Bladder Cancer, with Matvey Tsivian, MD

First Assist: Early Cystectomy in Non–Muscle Invasive Bladder Cancer, with Matvey Tsivian, MD

In this episode of First Assist: GU Oncology Unpacked, host Taylor Goodstein, MD, is joined by Matvey Tsivian, MD, to discuss how patient selection, staging, and quality-of-life considerations influen...

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