#140: How Real-World Evidence Is Shaping the Future of Multiple Sclerosis Treatment – Highlights from ECTRIMS 2025

#140: How Real-World Evidence Is Shaping the Future of Multiple Sclerosis Treatment – Highlights from ECTRIMS 2025

In this episode, I take you behind the scenes of ECTRIMS 2025 and explore seven fascinating studies that show how multiple sclerosis (MS) care is evolving — from safety monitoring and infection risks to data-driven, personalized treatment decisions.

You'll learn about:

  • How often late-onset neutropenia occurs in people on Rituximab and who's most at risk.

  • What factors increase the chance of serious infections with Ocrelizumab.

  • Why early high-efficacy treatment leads to better long-term outcomes across four countries.

  • What happens to memory B cells during long-term Ocrelizumab therapy and what that means for extended dosing intervals.

  • What the FAERS database tells us about tumor signals and why HPV vaccination remains essential for women with MS.

  • How real-world data from the TEMPOS study (France) reveal a massive shift toward anti-CD20 therapies — especially Ofatumumab.

  • And finally, how a new AI-based prediction tool helps estimate individual risk when stopping a DMT.

🎯 Main takeaway: MS treatment is moving toward earlier, stronger, and more personalized approaches — guided by real-world evidence and smart technology.

👉 You can read the full article with all study details, numbers, and takeaways here: https://ms-perspektive.de/en/140-ectrims-rwe

---

See you soon and try to make the best out of your life,
Nele

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Jaksot(192)

#190: Living with multiple sclerosis. Gabriela's story and the "(un)seen faces of MS" Art Project

#190: Living with multiple sclerosis. Gabriela's story and the "(un)seen faces of MS" Art Project

https://ms-perspektive.de/en/190-unseen-faces-of-ms/Living with multiple sclerosis often means experiencing symptoms that others cannot see. Austrian artist Gabriela Romagna shares her journey to an M...

4 Marras 32min

#189: New imaging in MS: understanding progression and finding better treatments | ECTRIMS 2026

#189: New imaging in MS: understanding progression and finding better treatments | ECTRIMS 2026

How could new imaging in MS help us understand progression and develop better treatments? In this episode, I explore key insights from Daniel Reich's MSToronto2026 lecture and related research. Learn ...

28 Loka 15min

#188: Jan Van Amstel on EMSP's Four-Year Presidency and the Future of MS Advocacy in Europe

#188: Jan Van Amstel on EMSP's Four-Year Presidency and the Future of MS Advocacy in Europe

"Get rid of MS as soon as possible and make ourselves superfluous." — Jan van Amstel What can a stronger European voice achieve for people living with MS? In episode #188, EMSP President Jan van Amste...

21 Loka 31min

#187: Aging in multiple sclerosis: relapses, progression and treatment choices with Dr. Yi Chao Foong

#187: Aging in multiple sclerosis: relapses, progression and treatment choices with Dr. Yi Chao Foong

Aging in multiple sclerosis brings new questions about relapses, gradual progression and treatment choices. In episode 187, Dr. Yi Chao Foong, an MS neurologist and researcher in Tasmania, explains wh...

14 Loka 29min

#186: Protecting nerve cells in multiple sclerosis: A new path toward neuroprotection with Prof. Manuel Friese

#186: Protecting nerve cells in multiple sclerosis: A new path toward neuroprotection with Prof. Manuel Friese

Why can multiple sclerosis progress even when relapses are well controlled? In episode 186, I speak with Prof. Manuel Friese about the next challenge in MS research: protecting nerve cells from damage...

7 Loka 43min

#185: Living with MS in Mexico – who gets diagnosed, who gets treated, and who gets left behind?

#185: Living with MS in Mexico – who gets diagnosed, who gets treated, and who gets left behind?

An MS diagnosis can depend on where you live, whether you can reach a neurologist and how quickly you can get an MRI. In this episode, Nele speaks with neurologist and neuroimmunologist Dr. Enrique Go...

30 Syys 36min

#184: MS treatment across the disease course – treat early, think long-term, don't give up too soon with Prof. Klaus Schmierer

#184: MS treatment across the disease course – treat early, think long-term, don't give up too soon with Prof. Klaus Schmierer

Read the full blog post and interview here: https://ms-perspektive.de/en/184-klaus-schmierer/ How early should MS treatment start, how strongly should we treat, and is there ever a point when it becom...

23 Syys 41min

#183: Silent progression in MS. Can we really detect it early?

#183: Silent progression in MS. Can we really detect it early?

Can we detect gradual MS progression before it becomes obvious? In this episode, I look at what current research can — and cannot — tell us about subtle worsening without an obvious relapse. The key d...

16 Syys 34min

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