10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


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• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Jaksot(1430)

Dan Yachter & Deed Harrison - Your place or spine?: #302

Dan Yachter & Deed Harrison - Your place or spine?: #302

Dr. Dan Yachter is the founder of Elevation Health, where he cares for thousands of patients each year at his state-of-the-art wellness center and conducts numerous educational workshops on the Elevation Health Core 4 wellness principles. Dr. Deed E. Harrison has developed and researched original spinal rehabilitation procedures and has lectured to thousands of chiropractors in over 300 educational conferences around the world. He has authored approximately 100 peer-reviewed spine related publications, 4 spine textbooks and numerous conference proceedings. On today's episode of Bulletproof Radio, this pair of expert chiropractors join Dave to talk about whole-body vibration, thermal imaging, perceived skepticism with chiropractic, how chiropractic work influences other aspects of the body and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Huhti 201659min

Anese Cavanaugh: Intention, Energy & Presence - #301

Anese Cavanaugh: Intention, Energy & Presence - #301

Anese Cavanaugh is devoted to helping people show up and bring their best selves to the table in order to create significant positive impact in their lives. She is the creator of the IEP Method, an advisor and thinking partner to leaders and organizations around the world, and author of Contagious Culture: Show Up, Set the Tone, and Intentionally Create an Organization That Thrives. As a leading voice on intention, energy and presence in leadership and culture, she helps people unlock greater leadership potential and collaborate more inspiringly. Today marks her second appearance on Bulletproof Radio, as she and Dave talk about internal awareness, managing fate, right and wrong energy, hiring and firing for energetic reasons and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Huhti 20161h

Barry Sears -  Fertility & Food, Flavonoids & Inflammation: #300

Barry Sears - Fertility & Food, Flavonoids & Inflammation: #300

Dr. Barry Sears is a leading authority on the impact of the diet on hormonal response, genetic expression and inflammation. He has published 40 scientific articles and holds 14 U.S. patents in the areas of intravenous drug delivery systems for cancer drugs and hormonal regulation for the treatment of cardiovascular disease. He's also the founder and president of the non-profit Inflammation Research Foundation from where he continues his work in the developing of new dietary approaches for the treatment of diabetes and cardiovascular and neurological diseases. On today's 300th episode of Bulletproof Radio, Barry and Dave talk about flavonoids, lab results in the food industry, inflammation, intermittent fasting, fertility through food and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Huhti 20161h 12min

Exclusive: Interview with Ketone Expert Dr. Richard Veech - #299

Exclusive: Interview with Ketone Expert Dr. Richard Veech - #299

For this special episode of Bulletproof Radio, we have an exclusive interview with Dr. Richard Veech. Dr. Veech is one of the world's foremost experts on ketosis, and this is the first time he has EVER been on a podcast. He's the Senior Researcher and Laboratory Chef at The National Institutes of Health and has worked for the last 47 years to understand the mechanics behind cellular energy and homeostasis. Dr. Veech is also the inventor of the ketone ester. On today's episode, you'll hear Dave and Dr. Veech discuss his ongoing research of ketones, including their potential dangers, the three different kinds, how to test for and raise them and how to use them as a vegan. Dr. Veech also talks to Dave about his work with George Cahill, General David Petraeus and several other significant figures over the course of his career. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

8 Huhti 20161h 19min

Anthony Coletti & Joe Martino - Collective Evolution: #298

Anthony Coletti & Joe Martino - Collective Evolution: #298

Joe Martino is the founder of Collective Evolution, an organization for people who want to change the world. After dropping out of college, he switched paths and focused on learning about what people felt needed to be transformed in the world. While running one of Canada's most successful medical marijuana businesses, Anthony Coletti was shot 7 times by a hitman and was left with nerve damage in his left arm. In his successful search to heal his mind and body, he came across the Bulletproof lifestyle and joined Joe at Collective Evolution. On this episode of Bulletproof Radio, the two talk with Dave about their stories, the future of Collective Evolution, gaining self-awareness, following your passion, social media compared to face-to-face interactions and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Huhti 20161h

April Q&A - Lyme Disease, Heart Rate Variability & Skincare: #297

April Q&A - Lyme Disease, Heart Rate Variability & Skincare: #297

In this episode of Bulletproof Radio, we've selected the best questions that Bulletproof fans submitted voicemail, Facebook and the Bulletproof® Forums, for a great April Q&A. Hear Dave answer questions with recurring guest Dr. Mark Atkinson about hair and blood testing, lyme disease, heart rate variability, different kinds of coffee brews and more. This episode covers a variety of topics based on your questions. Thank you and enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Huhti 20161h

Tony Stubblebine - Getting out of Your Robot Mindset: #296

Tony Stubblebine - Getting out of Your Robot Mindset: #296

Tony Stubblebine is the cofounder of Coach.me (formerly Lift), and he's making his second appearance on Bulletproof Radio. Coach.me was founded on the idea that positive reinforcement and community support could be deployed universally to help people achieve their goals. Prior to Coach.me, he was the founder and CEO of CrowdVine Event Social Networks, which builds simple and powerful social software to help people connect and meet. On today's episode, Tony and Dave talk about the move from tech into coaching, different methods of coaching, meditation and advice for young professionals and first-time managers. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

29 Maalis 201651min

Trina Felber - Primal Life Organics: Feed Your Skin #295

Trina Felber - Primal Life Organics: Feed Your Skin #295

Trina Felber is the creator of Primal Life Organics skin-food, a complete line of quality skincare products that don't just moisturize, clean or rejuvenate, they actually feed your skin and all the cells of your body with the nutrients to create optimum health. She's also the author of Beauty's Dirty Secret: 3 Simple Steps To Super Power Your Skin. On this episode of Bulletproof Radio, Dave and Trina talk about skincare ingredients, acne treatments, skincare while traveling, battling inflammation, skincare for guys and the differences between Primal Life Organics and the products sold by "Big Cosmo." Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25 Maalis 201655min

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