10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



Resources:

• Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Jaksot(1430)

Todd White - Biohacking Wine: Sulfates, Sugar & Dosing  #294

Todd White - Biohacking Wine: Sulfates, Sugar & Dosing #294

Todd White is a self-described biohacker and head of Dry Farm Wines. Dry Farm Wines curates wines from small family farms all over the world that are committed to producing pure natural wines. It is the only company in the world that biohacks wine; quantifying organic and natural farming practices, as well as low intervention natural winemaking practices. On this episode of Bulletproof Radio, Todd talks to Dave about sulfates and additives in wine, the dangers of sugar, wine label requirements, ideal alcohol dosages and wine pouring etiquette in restaurants. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

21 Maalis 20161h 14min

March Q&A: Breathwork, Stress Hacks, Combating Pre-Diabetes & More! - #293

March Q&A: Breathwork, Stress Hacks, Combating Pre-Diabetes & More! - #293

In this episode of Bulletproof Radio, we've selected the best questions that Bulletproof fans submitted via voicemail, Facebook and the Bulletproof® Forums, for another great Q&A. Hear Dave answer questions with recurring guest Dr. Mark Atkinson about pre-diabetes, pairing the Bulletproof diet with cycling and breastfeeding, stress and anxiety hacks, different methods of breathing, detoxing from mercury exposure and more. This episode covers a variety of topics based on your questions. Thank you and enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Maalis 20161h 6min

Philip Reed - A Priest, Blackjack Player, & $30,000 Walk Into a Bar... #292

Philip Reed - A Priest, Blackjack Player, & $30,000 Walk Into a Bar... #292

Philip Reed is a multi-platform author, writing about a variety of subjects in a simple and compelling style that changes people's lives. His sports series is about performance under pressure in basketball, golf and blackjack and his latest book is "Wild Cards, A Year Counting Cards with a Professional Blackjack Player, a Priest and a $30,000 bankroll." On this episode of Bulletproof Radio, Philip sits down with Dave to talk about counting cards, cognitive enhancement in the casino, working memory, the importance of mentorship and teamwork, performance learning curves and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Maalis 201654min

Helen Irlen - Your Glass Is Always Full Through Irlen Lenses: #291

Helen Irlen - Your Glass Is Always Full Through Irlen Lenses: #291

Helen Irlen is an internationally recognized educator, researcher, therapist, scholar and expert in the area of visual-perceptual disorders. Helen discovered Irlen Syndrome over 20 years ago, after establishing that individuals showed a marked improvement in their reading ability when reading material was covered by colored acetate sheets. In the years since, Helen has taught thousands, from schoolchildren to NFL players, to utilize colors to boost brain function. Helen is a regular on BPR and on this episode of Bulletproof Radio, she sits down with Dave to talk about Irlen Syndrome, visual perception and performance, ideal light settings, behavioral problems stemming from light, issues with fluorescent lights, Irlen lenses and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Maalis 20161h 10min

HigherDOSE - The Healing Benefits of Infrared: #290

HigherDOSE - The Healing Benefits of Infrared: #290

Lauren Berlingeri and Katie Kaps are the founders of HigherDOSE, where they bring the benefits of infrared to yoga and fitness. Lauren studied at The Institute of Integrative Nutrition where she became a certified holistic nutritionist and health coach, and starred in the Woman vs. Workout YouTube series. Katie took several startups to the next level in Silicon Valley and Wall Street before beginning her work with HigherDOSE. On today's episode of Bulletproof Radio, Dave sits down with the two to talk about the benefits of infrared light, traditional saunas and infrared saunas, different wavelengths and their effects, Women vs. Workout, carbon and ceramic heaters and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

8 Maalis 201652min

The Ibogaine Experience - Treating Addiction with Alternative Medicine: #289

The Ibogaine Experience - Treating Addiction with Alternative Medicine: #289

On this episode of Bulletproof Radio you will hear from experts, Dr. Martin Polanco, Dr. Dan Engle and Deanne Adamson about the world of alternative drug addiction treatment. Dr. Martin Polanco and Dr. Dan Engle are the founders of the famed Crossroads Treatment Center in New Mexico, where they help addicts overcome drug addiction through use of the psychedelic drug Ibogaine. Deanne Adamson, founder of Being True To You, provides addiction recovery coaching to patients as well as preparation & integration services surrounding transformational experiences. On this episode of Bulletproof Radio, the trio talk with Dave about Ibogaine treatment, the rehabilitation process, DMT use, uncovering trauma and the ethics of rehabilitation through psychedelics. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Maalis 20161h 5min

Mark Hyman - Meat Is The New Ketchup: #288

Mark Hyman - Meat Is The New Ketchup: #288

Dr. Mark Hyman is a practicing family physician, a New York Times bestselling author, and an internationally recognized leader, speaker, educator and advocate in the field of Functional Medicine. He is the Director of the Cleveland Clinic Center for Functional Medicine and his latest book is titled Eat Fat, Get Thin: Why the Fat We Eat Is the Key to Sustained Weight Loss and Vibrant Health. On this episode of Bulletproof Radio, Dave and Mark talk about how to get thin by eating fat, red meats, Omega 3s, stress management, structural fats, hypercholesterolemia, MCT oils and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Maalis 20161h 6min

Brant Cortright - Neurogenesis Diet & Combating Cognitive Decline: #287

Brant Cortright - Neurogenesis Diet & Combating Cognitive Decline: #287

Brant Cortright, Ph.D. is a Professor of psychology at the California Institute of Integral Studies. He is the author of the #1 international bestseller The Neurogenesis Diet and Lifestyle: Upgrade Your Brain, Upgrade Your Life., a holistic approach to optimizing brain health. He joins Dave on the show today to talk about neurogenesis during pregnancy, diet tips, Omega 3s, the dangers of sugar, exercising your brain and combating cognitive decline. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Helmi 20161h 2min

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