10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



Resources:

• Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome

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• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

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Jaksot(1423)

#81 Revisiting The Calorie Myth with Jonathan Bailor

#81 Revisiting The Calorie Myth with Jonathan Bailor

Have you ever wanted to bash your bathroom scale in with a really large sledgehammer? Bulletproof Radio guest and passionate calorie myth buster, Jonathan Bailor, wants you to do just that! On this episode, Bailor brings back his wealth of knowledge to the show and discusses why counting calories does not make your life better – in fact it can make your life worse. You’ll also hear about the epidemic of girls and calorie counting,  weight loss success rates when counting calories,  and why we should definitely stop freebasing with Oreos!? It’s a great show with tons of information. Enjoy it! Jonathan Bailor is a nutrition and exercise expert and former personal trainer who specializes in using high-quality food and exercise to simplify wellness. He has registered over 25 patents and authored the revolutionary upcoming The Calorie Myth (HarperCollins, 12.31.13). Bailor serves as a Senior Program Manager at Microsoft, hosts a popular syndicated wellness radio show, blogs on The Huffington Post, and consults for organizations around the world. His free 28-day quick-start eating and exercise guide is available at BailorGroup.com. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Joulu 201346min

#80 Be More Successful With Gratitude and UJ Ramdas

#80 Be More Successful With Gratitude and UJ Ramdas

‘Tis the season to be grateful! And while that sentiment can often feel a bit disingenuous, it turns out that practicing gratitude can actually make you happier, more effective, and smarter! On this episode of Bulletproof Radio, hypnotist and behavioral biohacker UJ Ramdas talks about the many ways in which gratitude can make you a more successful person. You will learn about the benefits of being resilient, how to put pen to paper, and a short list of things you can do each day to express your gratitude. Oh! And UJ offers a special surprise to Bulletproof listeners! Please enjoy. UJ Ramdas is passionate about bringing together practical psychology and business to create a better world. With a background in Behavioral science, Marketing and Hypnosis, he’s consulted with (several hundred) clients, bringing them from confusion to clarity. Currently based out of Toronto, Canada, he’s a big fan of the wilderness, eastern meditative practices and a good cup of tea. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Joulu 201346min

#79 Shamanic Biohacking with Alberto Villoldo

#79 Shamanic Biohacking with Alberto Villoldo

Shamanism and science aren’t often thought of as being allies of one another. Should they be? It turns out that ancient shamans were some of our first brain scientists and biohackers! Expect to take note on this episode of Bulletproof Radio with the inspirational shaman, biohacker, and teacher Alberto Villoldo. There is a ton of useful information to be learned from this talk with Alberto including why a broken diet equals a broken brain, what are the right kinds of medicine plants, and how to, “Pass the salt, bitch!” Trust me; you’ll want to listen. It’s a real honor to have such a wise and humble healer on the show. You won’t be disappointed!  Alberto Villoldo, Ph.D., a psychologist and medical anthropologist, has studied the healing practices of the Amazon and Inka shamans for more than 25 years. While at San Francisco State University, he founded the Biological Self-Regulation Laboratory to study how the mind creates psychosomatic health and disease. Dr. Villoldo directs The Four Winds Society, where he trains individuals throughout the world in the practice of energy medicine. Founder of The Four Winds Society, Alberto instructs individuals throughout the world in the practice of energy medicine.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Joulu 20131h

#77 The New Man with Tripp Lanier

#77 The New Man with Tripp Lanier

Americans spend billions each year on self-help, and this maybe isn’t totally surprising, but women are the target audience of the industry more often than not. Which is why the role of men’s coach Tripp Lanier is so important, to help fill in the gap. Let’s face it! Men need help too, right? On this episode of Bulletproof Radio Tripp talks about self-help from a man’s perspective and how to upgrade your life from a more masculine point of view. You’ll hear about why understanding your whole body matters, how being in the wrong relationship can keep you from being optimal, and Tripp shares a very personal story of trauma and how it affected his own personal development. Tripp’s a great guy. It was awesome to have him on the show. Enjoy! Tripp Lanier is a men’s coach and host of The New Man Podcast. He coaches and teaches men all around the world how to break out of mediocre lives and create the careers and relationships they really want. As a host, he’s interviewed experts and authors from all walks of life including Tim Ferriss, Laird Hamilton, Ken Wilber, Dan Millman, Marcus Buckingham, Bill Harris, Steven Pressfield, AJ Jacobs, Chip Conley, Dr. Robert Glover, and Shawn Phillips. The New Man Podcast reaches thousands of people in over 110 countries and regularly finds its home on the iTunes Self-Help Top 10 list. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

22 Marras 201355min

#76 The Paleo Primer with Keris Mardsen and Matt Whitmore

#76 The Paleo Primer with Keris Mardsen and Matt Whitmore

On this episode of Bulletproof Radio authors of “The Paleo Primer,” Keris Mardsen and Matt Whitmore bring a British perspective to Primal cooking. This powerful duo aim to make cooking Paleo fun and upgrade people’s lives by teaching healthier living techniques. On this show you’ll learn how to pimp your salad, how horse meat is healthier than you thought, and how to torture your liver! Please enjoy these two charming Brits and their take on Paleo living.  Keris Marsden and Matt Whitmore are based in the UK and own a group of training and nutrition companies called Fitter London and Fitter Food. As personal trainers, they were tired of treadmills, cross trainers, machines, and the same old class timetable. With a combined experience of more than 20 years training themselves and working in the industry they decided it was time for a change and wanted to bring some variety, innovation, and spontaneity back to boring gym workouts and repetitive classes. Keris is a nutrition geek while Matt loves cooking and being creative in the kitchen. Together they make the perfect team, educating clients and readers about nutrition and providing tasty recipes and essential resources to ensure that Primal/Paleo becomes a lifestyle, not just a diet. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Marras 201342min

#75 Heavy Metal Bulletproof with Mark Hunter

#75 Heavy Metal Bulletproof with Mark Hunter

What’s better than sex, drugs, and rock-n-roll? Sex, drugs, rock-n-roll and Bulletproof® coffee, perhaps? On episode #75 of Bulletproof Radio heavy metal biohacker and front man of the band Chimaira, Mark Hunter, gives us an inside look at living like a rock star and being Bulletproof. It was great to get to hear about how Mark got turned on to the Bulletproof lifestyle and what he does to stay optimal as a performer. You’ll learn about Mark’s works to help people live a better life, how coffee affects his music, and why sexual abstinence can help you attract more women! This is a down to earth conversation with a hardcore fan and a crazy talented musician. Please enjoy! Mark Hunter is the vocalist and founding member of Cleveland-based metal band Chimaira. Mark has been a professional musician for 15+ years with more than a million records sold. He is a producer, blogger, float tank enthusiast, biohacker, and newly found wellness coach. After losing over 40 pounds on the Bulletproof® Diet, Mark has helped his mother lose over 120 pounds and recover from type-2 diabetes. Links on where to find out more about Mark and Chimaira can be found in this episode's blog post at http://bulletproofexec.com.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Marras 201355min

#74 Learning Should Not Be Easy with Andrea Kuszewski

#74 Learning Should Not Be Easy with Andrea Kuszewski

Who said that learning should be easy? Not Andrea Kuszewski, a spirited researcher and science writer. On this episode of Bulletproof Radio Andrea even suggests that learning is painful and should perhaps be valued for its ability to make our brains hurt! Kuszewski is impressive and gave an incredibly useful insight into her research as she works to revolutionize education. On this show you’ll learn: why women can make men dumb, about Andrea’s brain hacks, and how to identify a sociopath. Watch out! It’s a good one. Enjoy! As a self-described nerd, Andrea Kuszewski is also a researcher, therapist, and scientific consultant – to name a few. Her main interests are creativity, intelligence, autism, exceptional ability, x-altruism, and sociopathy, and what motivates people to change their behavior. She is a frequent contributor to Scientific American and the Institute for Ethics and Emerging Technologies. Kuszewski lives in the San Francisco, California and in her spare time enjoys obsessing over brains, glittery things, and Triceratops, but not necessarily in that order. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Marras 201350min

#73 SomaPulse & Electromagnetism with Dr. Bill Pawluk

#73 SomaPulse & Electromagnetism with Dr. Bill Pawluk

Have you ever wondered how magnets work? Or better yet: how they can help you be healthier? The amazingly gifted Dr. William (Bill) Pawluk is on this episode of Bulletproof Radio to answer these questions, and then some. Bill delves deep into the science behind electromagnetism and how it can help you eliminate or significantly reduce painful inflammation, stimulate tissue healing, and fully support the body’s inherent healing abilities. There’s also an immensely generous surprise, but you have to listen for that! Dr. Pawluk is a board-certified family physician, with training in acupuncture, homeopathy, hypnosis and bodywork. He practices holistic medicine in Baltimore and appears regularly on the radio at www.wcbm.com. In addition, he is a national expert in the medical use of electromagnetics with over 22 years of experience.  In recognition of this experience he has appeared on the Dr. Oz show regarding magnetic therapy devices. As part of his work with this technology, he has authored numerous books, chapters, articles and interviews on magnetics, conducts research on the use of various kinds of electromagnetic systems on wound healing and other applications, and teaches practitioners on the appropriate use of magnetic therapies. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

8 Marras 201354min

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