10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



Resources:

• Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Jaksot(1423)

#55 Fitness, Nutrition & Bulletproof Habits, with High Performance Health Coach, Yuri Elkaim

#55 Fitness, Nutrition & Bulletproof Habits, with High Performance Health Coach, Yuri Elkaim

From professional athlete to high performance health coach, Yuri Elkaim joins us today to talk about (almost) all things Bulletproof. In his goal to help 10,000,000 people become healthier, Yuri will share his take on raw food, the “fruit & veg” argument, exercise vs. rest, habits, and more! If you are an athlete (or biohacker) looking for 1 or 2 tips to take your performance to the next level, this is the show for you. Yuri Elkaim is a registered holistic nutritionist, fitness expert, and highly sought after high performance health coach. He’s also a former professional soccer player and served as the Head Strength & Conditioning and Nutrition Coach for men’s soccer at the University of Toronto for 7 seasons. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Elo 201346min

#54 Neurofeedback Technology, Best Biohack Yet, with Dr. Valdeane Brown

#54 Neurofeedback Technology, Best Biohack Yet, with Dr. Valdeane Brown

This episode is all about the most effective biohack I’ve experience yet – NeurOptimal® brain training. Dr. Valdeane Brown, Founder of NeurOptimal, came on the show to explain how this technology takes your performance to uncharted levels! The NeurOptimal brain trainer is the most powerful and affordable neurofeedback technology available. You will get to hear about the EEG technology and how it transforms your brain, upgrade athletic performance, and even help with migraines, PTSD, and abusive relationships. Does this sound too good to be true? Listen for yourself… Dr. Valdeane W. Brown is an internationally recognized "trainer of neurofeedback trainers", who has taught and consulted widely on personal and organizational transformation. With a Ph.D. in Clinical Psychology and a background in math, physics, computer programming, philosophy, yoga, meditation and martial arts, Dr. Brown brings a presence and precision to his work. This is further informed by a profound sense of compassion, a facility with energy dynamics and a deep commitment to revealing the elegant simplicity inherent in learning and transformation. Developer of the Five Phase Model and co-creator with his wife Sue of the Period 3 Approach to Clinical Neurofeedback, Dr. Brown has realized his vision of a truly comprehensive training system in NeurOptimal. His vision in bringing NeurOptimal to the world is to make personal transformation effortless and available to all. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Elo 20131h 1min

#53 Raw Vegan to Bulletproof Meat Eater - a beneficial transformation, with Kristen 'Raw' Suzanne

#53 Raw Vegan to Bulletproof Meat Eater - a beneficial transformation, with Kristen 'Raw' Suzanne

This episode brings to light an ex-vegan advocate’s journey to eating a mostly meat-embraced Bulletproof diet. Kristen ‘Raw’ Suzanne, author, popular blogger, and nutrition researcher, shared her former vegan assumptions, how easy or difficult it was to change, and the ethics of food. We also dove into a detailed conversations about liver meat, fertility issues on a vegan diet, how to stay Bulletproof when traveling with family, and how to nourish your kids the best way possible. In 2005, Kristen walked away from her corporate career in executive-level operations to focus on her true passion: healthy food. Already a vegan for two years, she turned her attention to the raw vegan cuisine and lifestyle, initially teaching classes and providing personal chef services, but as her online audience grew, she ultimately shifted to full-time blogging, recipe development, and eventually publishing 12 books on raw vegan diets. By 2012, concerns with her and her child's health forced her to reevaluate the nutritional claims made by advocates of raw and vegan diets. After Kristen introduced high quality animal products into her family's diet, she saw dramatic improvements almost immediately. Her family now eats a diet high in grass-fed beef and butter, bison, pastured eggs, and wild-caught seafood, while avoiding grains, gluten, and soy. While her personal transformation and conversion from vegan to omnivore has been controversial in the vegan and raw food community, Kristen has been on hiatus from blogging to spend time researching and fully exploring the nutritional and culinary aspects of eating in this new way for her family. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Elo 201357min

#52 – Sex, Sex Culture & Sex at Dawn with Christopher Ryan - Podcast

#52 – Sex, Sex Culture & Sex at Dawn with Christopher Ryan - Podcast

Welcome to our first ever VIDEO and audio podcast, where we’re celebrating by exploring everyone’s favorite topic – sex! This episode, with co-author of New York Times best seller, Sex at Dawn: How We Mate, Why We Stray, and What it Means for Modern Relationships, Christopher Ryan, gives you a peak into the evolutionary view of human sexual behavior. Sex at Dawn shatters myths surrounding the societal history behind how men and women interact in sexual relationships. Christopher made for a great interview, as he continues to rustle feathers around the ideas of traditional relationships.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Heinä 201353min

#51 Transhumanism, Technology & the Future with Natasha Vita-More

#51 Transhumanism, Technology & the Future with Natasha Vita-More

This episode stretches the boundaries of biohacking by looking at the futurist ideology and movement called transhumanism. Natasha Vita-More, an American designer, theorist and author, joined me on this episode to discuss the possible transformation of the human condition by developing technologies that enhance intellectual, physical, and psychological capacities.  Natasha Vita-more is co-editor and author of The Transhumanist Reader: Classical and Contemporary Essays on the Science, Technology and Philosophy of the Human Future and designer and author of "Primo Posthuman," a pioneering future whole body prototype. Vita-More is a professor at the University of Advancing Technology, and a Fellow of the Institute for Ethics and Emerging Technologies and the Hybrid Reality Institute. She is currently Chairman of the Board of Directors of Humanity+. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Heinä 201349min

#50 New Bulletproof iPhone App, Food Sensitivities & HRV with Ronda Collier from SweetWater Health

#50 New Bulletproof iPhone App, Food Sensitivities & HRV with Ronda Collier from SweetWater Health

The 50th episode of Bulletproof Executive Radio introduces you to a brand new free iPhone app called Bulletproof(R) Food Sense and to the scientist who made it all happen.  Today’s interview is with long time biohacker and founder of Sweetwater Health™, Ronda Collier. Ronda is putting her more than 25 years of experience in high tech to work at SweetWater Health™, where they are looking at the signal coming from the human heart, and instead of seeing beats per minute or simple heart rate variability, seeing a huge pool of big data just waiting to be analyzed using Ronda’s crazy advanced math skills. There is a lot more information in your heartbeat than you’d think – stress levels are just the beginning. By applying mobile health monitoring and stress management with medical research techniques, SweetWater Health is creating some very advanced, very easy to use biohacking technologies. My experience as a bio hacker who used to weigh 300 pounds and really struggled with food cravings, is that every single person has a set of things in their environment or their food that makes them weak. SweetWater Health and Bulletproof Executive just partnered to create the free Bulletproof(R) Food Sense iPhone app to help you find your personal kryptonite by using the phone’s onboard sensors to detect your hidden food sensitivities.   You can also get an amazingly full-featured version of the app that works with a chest strap to measure and track your heart rate variability all day long and use complex algorithms to quantify your food, stress, and overall health. Click here to download your free Bulletproof Food Sense app from the Apple iTunes store. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

16 Heinä 201348min

#49 Q & A Eggs, Butter & Zen - Podcast

#49 Q & A Eggs, Butter & Zen - Podcast

About once a month, I set aside a whole podcast to answer questions from the Bulletproof community. It's all about answering your very best questions, sourced from e-mail, Facebook, Twitter, the Bulletproof forum and the blog! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Heinä 201359min

#48 “Fat Burning Man,” Abel James and Bulletproof Exec Unite

#48 “Fat Burning Man,” Abel James and Bulletproof Exec Unite

This podcast is with Abel James – a #1 best-selling author, fat loss coach, musician, radio show host, and veritable health crusader. Abel also runs the extremely popular “Fat Burning Man” show – which is one of the top health podcasts on iTunes.  A former strategic advisor to the food and beverage industry, Abel now acts as a consumer advocate who exposes the truth behind deceptive marketing practices, misleading corporate propaganda, and powerful special interests that have accelerated the worldwide obesity epidemic and health crisis. Abel harnesses the techniques he developed for the Lean Body System to achieve extremely compelling results in fat loss and health for his clients and the community. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Heinä 201356min

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