Orthostatic Pulse Pressure and SGLT2 Inhibitors: Findings from PRESERVED-HF | JACC Baran
JACC Global26 Elo 2025

Orthostatic Pulse Pressure and SGLT2 Inhibitors: Findings from PRESERVED-HF | JACC Baran

Hosts Mitsuaki Sawano, MD, Shun Kohsaka, MD, Nobuhiro Ikemura, MD, and Satoshi Shoji, MD, welcome Dr. Hidenori Yaku to discuss orthostatic pulse pressure (OPP) as a marker of preload insufficiency in HFpEF, based on a prespecified analysis from the PRESERVED-HF trial. Dr. Yaku reviews findings from 324 patients with HFpEF randomized to dapagliflozin or placebo. Across groups with high, intermediate, or low OPP, dapagliflozin improved health status as measured by the Kansas City Cardiomyopathy Questionnaire and increased six-minute walk distance, with no significant interaction by OPP level. However, fluid depletion–related adverse events, although infrequent overall, were observed more often in patients with the lowest OPP. These results suggest that simple measurement of OPP may help identify patients at higher risk for volume depletion events, while the symptomatic and functional benefits of SGLT2 inhibition are preserved across the spectrum of OPP.

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HFpEF and HFmrEF: Can KCCQ-12 Replace KCCQ-23? | JACC Baran

HFpEF and HFmrEF: Can KCCQ-12 Replace KCCQ-23? | JACC Baran

Hosts Mitsuaki Sawano, MD, Kentaro Ejiri, MD, and Nobuhiro Ikemura, MD welcome Dr. Yasuhiro Hamatani, MD (Brigham and Women’s Hospital) to discuss his study, “Interchangeability of the KCCQ-12 and KCC...

26 Touko 33min

Can AI Predict AF Recurrence After Cardioversion? | JACC Baran

Can AI Predict AF Recurrence After Cardioversion? | JACC Baran

Hosts Mitsuaki Sawano, MD, and Satoshi Shoji, MD welcome Dr. Keisuke Usuda, MD (Massachusetts General Hospital / Broad Institute of MIT and Harvard) to discuss his JACC: Clinical Electrophysiology stu...

19 Touko 32min

Mitral Stenosis: Beyond Rheumatic Disease | JACC Baran

Mitral Stenosis: Beyond Rheumatic Disease | JACC Baran

Hosts Mitsuaki Sawano, MD, Kentaro Ejiri, MD, and Nobuhiro Ikemura, MD welcome Dr. Nahoko Kato, MD, PhD (Tokyo Bay Urayasu Ichikawa Medical Center) and Dr. Hiroyuki Okura, MD, PhD (Gifu University) to...

12 Touko 31min

AF Ablation and the Brain: Does It Improve Blood Flow and Cognition? | JACC Baran

AF Ablation and the Brain: Does It Improve Blood Flow and Cognition? | JACC Baran

Hosts Mitsuaki Sawano, MD, Satoshi Shoji, MD, Nobuhiro Ikemura, MD, and Hiroyuki Sato, MD welcome Dr. Tasuku Yamamoto, MD (Cleveland Clinic) to discuss his JACC: Clinical Electrophysiology study, “Neu...

5 Touko 41min

Acute PE in Practice: An APAC View on the New AHA/ACC Guideline | JACC Baran

Acute PE in Practice: An APAC View on the New AHA/ACC Guideline | JACC Baran

Hosts Mitsuaki Sawano, MD, and Shun Kohsaka, MD, welcome Dr. Yugo Yamashita, MD (Kyoto University) to discuss the newly released 2026 AHA/ACC Guideline for Acute Pulmonary Embolism and its accompanyin...

28 Huhti 42min

Marfan Syndrome: Timing Surgery Through Genetics | JACC Baran

Marfan Syndrome: Timing Surgery Through Genetics | JACC Baran

Hosts Mitsuaki Sawano, MD, welcome Dr. Yuki Kawashima, MD and Dr. Ryo Inuzuka, MD (The University of Tokyo) to discuss their JACC study on how genetic variants in FBN1 can predict the timing and risk ...

21 Huhti 36min

Unraveling HCM Heterogeneity Using Circulating microRNAs | JACC Baran

Unraveling HCM Heterogeneity Using Circulating microRNAs | JACC Baran

Hosts Mitsuaki Sawano, MD, Shun Kohsaka, MD, and Nobuhiro Ikemura, MD welcome Dr. Yuichi J. Shimada (Columbia University) to discuss his ACC presentation on plasma microRNA profiling in hypertrophic c...

14 Huhti 27min

Chagas Cardiomyopathy — Epidemiology Through Modern Clinical Trials | JACC Baran

Chagas Cardiomyopathy — Epidemiology Through Modern Clinical Trials | JACC Baran

Hosts Mitsuaki Sawano, MD, Shun Kohsaka, MD, and Nobuhiro Ikemura, MD welcome Dr. Ryohei Ono, MD, PhD (University of Glasgow / Chiba University) to discuss his simultaneously published JACC study anal...

7 Huhti 19min

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