2025 Highlight-o-thon: Oops! All Bests

2025 Highlight-o-thon: Oops! All Bests

It’s that magical time of year once again — highlightapalooza! Stick around for one top bit from each episode we recorded this year, including:

  • Kyle Fish explaining how Anthropic’s AI Claude descends into spiritual woo when left to talk to itself
  • Ian Dunt on why the unelected House of Lords is by far the best part of the British government
  • Sam Bowman’s strategy to get NIMBYs to love it when things get built next to their houses
  • Buck Shlegeris on how to get an AI model that wants to seize control to accidentally help you foil its plans

…as well as 18 other top observations and arguments from the past year of the show.

Links to learn more, video, and full transcript: https://80k.info/best25

It's been another year of living through history, whether we asked for it or not. Luisa and Rob will be back in 2026 to help you make sense of whatever comes next — as Earth continues its indifferent journey through the cosmos, now accompanied by AI systems that can summarise our meetings and generate adequate birthday messages for colleagues we barely know.

Chapters:

  • Cold open (00:00:00)
  • Rob's intro (00:02:35)
  • Helen Toner on whether we're racing China to build AGI (00:03:43)
  • Hugh White on what he'd say to Americans (00:06:09)
  • Buck Shlegeris on convincing AI models they've already escaped (00:12:09)
  • Paul Scharre on a personal experience in Afghanistan that influenced his views on autonomous weapons (00:15:10)
  • Ian Dunt on how unelected septuagenarians are the heroes of UK governance (00:19:06)
  • Beth Barnes on AI companies being locally reasonable, but globally reckless (00:24:27)
  • Tyler Whitmer on one thing the California and Delaware attorneys general forced on the OpenAI for-profit as part of their restructure (00:28:02)
  • Toby Ord on whether rich people will get access to AGI first (00:30:13)
  • Andrew Snyder-Beattie on how the worst biorisks are defence dominant (00:34:24)
  • Eileen Yam on the most eye-watering gaps in opinions about AI between experts and the US public (00:39:41)
  • Will MacAskill on what a century of history crammed into a decade might feel like (00:44:07)
  • Kyle Fish on what happens when two instances of Claude are left to interact with each other (00:49:08)
  • Sam Bowman on where the Not In My Back Yard movement actually has a point (00:56:29)
  • Neel Nanda on how mechanistic interpretability is trying to be the biology of AI (01:03:12)
  • Tom Davidson on the potential to install secret AI loyalties at a very early stage (01:07:19)
  • Luisa and Rob discussing how medicine doesn't take the health burden of pregnancy seriously enough (01:10:53)
  • Marius Hobbhahn on why scheming is a very natural path for AI models — and people (01:16:23)
  • Holden Karnofsky on lessons for AI regulation drawn from successful farm animal welfare advocacy (01:21:29)
  • Allan Dafoe on how AGI is an inescapable idea but one we have to define well (01:26:19)
  • Ryan Greenblatt on the most likely ways for AI to take over (01:29:35)
  • Updates Daniel Kokotajlo has made to his forecasts since writing and publishing the AI 2027 scenario (01:32:47)
  • Dean Ball on why regulation invites path dependency, and that's a major problem (01:37:21)


Video and audio editing: Dominic Armstrong, Milo McGuire, Luke Monsour, and Simon Monsour
Music: CORBIT
Coordination, transcripts, and web: Katy Moore

Episoder(332)

#11 - Spencer Greenberg on speeding up social science 10-fold & why plenty of startups cause harm

#11 - Spencer Greenberg on speeding up social science 10-fold & why plenty of startups cause harm

Do most meat eaters think it’s wrong to hurt animals? Do Americans think climate change is likely to cause human extinction? What is the best, state-of-the-art therapy for depression? How can we make ...

17 Okt 20171h 29min

#10 - Nick Beckstead on how to spend billions of dollars preventing human extinction

#10 - Nick Beckstead on how to spend billions of dollars preventing human extinction

What if you were in a position to give away billions of dollars to improve the world? What would you do with it? This is the problem facing Program Officers at the Open Philanthropy Project - people l...

11 Okt 20171h 51min

#9 - Christine Peterson on how insecure computers could lead to global disaster, and how to fix it

#9 - Christine Peterson on how insecure computers could lead to global disaster, and how to fix it

Take a trip to Silicon Valley in the 70s and 80s, when going to space sounded like a good way to get around environmental limits, people started cryogenically freezing themselves, and nanotechnology l...

4 Okt 20171h 45min

#8 - Lewis Bollard on how to end factory farming in our lifetimes

#8 - Lewis Bollard on how to end factory farming in our lifetimes

Every year tens of billions of animals are raised in terrible conditions in factory farms before being killed for human consumption. Over the last two years Lewis Bollard – Project Officer for Farm An...

27 Sep 20173h 16min

#7 - Julia Galef on making humanity more rational, what EA does wrong, and why Twitter isn’t all bad

#7 - Julia Galef on making humanity more rational, what EA does wrong, and why Twitter isn’t all bad

The scientific revolution in the 16th century was one of the biggest societal shifts in human history, driven by the discovery of new and better methods of figuring out who was right and who was wrong...

13 Sep 20171h 14min

#6 - Toby Ord on why the long-term future matters more than anything else & what to do about it

#6 - Toby Ord on why the long-term future matters more than anything else & what to do about it

Of all the people whose well-being we should care about, only a small fraction are alive today. The rest are members of future generations who are yet to exist. Whether they’ll be born into a world th...

6 Sep 20172h 8min

#5 - Alex Gordon-Brown on how to donate millions in your 20s working in quantitative trading

#5 - Alex Gordon-Brown on how to donate millions in your 20s working in quantitative trading

Quantitative financial trading is one of the highest paying parts of the world’s highest paying industry. 25 to 30 year olds with outstanding maths skills can earn millions a year in an obscure set of...

28 Aug 20171h 45min

#4 - Howie Lempel on pandemics that kill hundreds of millions and how to stop them

#4 - Howie Lempel on pandemics that kill hundreds of millions and how to stop them

What disaster is most likely to kill more than 10 million human beings in the next 20 years? Terrorism? Famine? An asteroid? Actually it’s probably a pandemic: a deadly new disease that spreads out o...

23 Aug 20172h 35min

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