#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics

Tom Brands is an Olympic and World Champion in freestyle wrestling and the head wrestling coach at the University of Iowa. Please support this podcast by checking out our sponsors: - FightCamp: https://joinfightcamp.com/lex to get free shipping - InsideTracker: https://insidetracker.com/lex and use code Lex25 to get 25% off - ROKA: https://roka.com/ and use code LEX to get 20% off your first order - Theragun: https://therabody.com/lex to get 30 day trial - GiveWell: https://www.givewell.org/ and use code LEX to get donation matched up to $1k EPISODE LINKS: Tom's Twitter: https://twitter.com/tombrandshawk Hawkeyes' Website: https://hawkeyesports.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (10:08) - Motivation (24:08) - Mental toughness (28:36) - Weight cutting (30:24) - Olympic dreams (35:20) - 1996 Olympic Games in Atlanta (38:24) - Brother (43:36) - Champion mindset (49:36) - Beyond limits (54:37) - Faith (56:06) - Family (1:00:11) - Brands vs Brands

30 Nov 20211h 3min

Robert Crews is a historian at Stanford, specializing in Afghanistan, Russia, Islam, Central Asia, and South Asia. Please support this podcast by checking out our sponsors: - MUD\WTR: https://mudwtr.com/lex and use code LEX to get 5% off - Ten Thousand: https://www.tenthousand.cc/ and use code LEX to get 15% off - Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off - Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off - Onnit: https://lexfridman.com/onnit to get up to 10% off EPISODE LINKS: Robert's Twitter: https://twitter.com/RobertCrews22 Robert's Stanford page: https://profiles.stanford.edu/robert-crews Afghan Modern (book): https://amzn.to/3nYL5rX PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (06:42) - U.S. invasion of Afghanistan (21:30) - September 11 (39:05) - Bin Laden (1:14:35) - Withdrawal of U.S. troops (2:06:47) - War (2:18:01) - Leadership (2:34:11) - Afghan people (2:43:40) - Rumi

28 Nov 20212h 49min

Kevin Systrom is the co-founder and former CEO of Instagram. Please support this podcast by checking out our sponsors: - Theragun: https://therabody.com/lex to get 30 day trial - NI: https://www.ni.com/perspectives - GiveWell: https://www.givewell.org/ and use code LEX to get donation matched up to $1k - Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium - Fundrise: https://fundrise.com/lex EPISODE LINKS: Kevin's Instagram: https://www.instagram.com/kevin/ Kevin's Twitter: https://twitter.com/kevin Kevin's LinkedIn: https://www.linkedin.com/in/kevinsystrom PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (08:26) - Origin of Instagram (50:33) - New social networks (1:09:38) - Selling Instagram to Facebook (1:32:40) - Features (1:36:47) - Facebook (2:13:28) - Whistleblower (2:24:47) - Machine learning (2:34:45) - Advice for startups (2:40:37) - Money (2:46:37) - Love (2:48:54) - Meaning of life

23 Nov 20212h 52min

Ben Askren is a wrestler and MMA fighter, former Bellator and ONE Championship welterweight champion, a two-time NCAA wrestling champion and four-time finalist. Please support this podcast by checking out our sponsors: - Notion: https://notion.com/startups to get up to $1000 off team plan - NI: https://www.ni.com/perspectives - Onnit: https://lexfridman.com/onnit to get up to 10% off - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings - NetSuite: http://netsuite.com/lex to get free product tour EPISODE LINKS: Ben's Twitter: https://twitter.com/Benaskren Ben's Instagram: https://www.instagram.com/benaskren/ Ben's Website: https://www.benaskren.com/ Ben's Wrestling Academy: https://awawisconsin.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (06:59) - Woodley vs Jake Paul boxing match (10:48) - Askren vs Jake Paul boxing match (13:23) - Jordan Burroughs and Kyle Dake (24:37) - Askren vs Burroughs charity match (29:21) - Champion mentality and handling losses (43:40) - Future interest in competition (53:09) - Askren's early career (1:03:58) - Robots wrestling (1:18:39) - Olympics (1:24:46) - Dagestan wrestling (1:30:51) - Askren Wrestling Academy (1:46:32) - Khabib Nurmagomedov (1:53:08) - 2020 Olympics (1:54:49) - Wrestling dominance in MMA

20 Nov 20212h 21min

Boris Sofman is the Senior Director Of Engineering and Head of Trucking at Waymo, formerly the Google Self-Driving Car project. He was also the CEO and co-founder of Anki, a home robotics company. Please support this podcast by checking out our sponsors: - LMNT: https://drinkLMNT.com/lex to get free sample pack - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil - ROKA: https://roka.com/ and use code LEX to get 20% off your first order - Indeed: https://indeed.com/lex to get $75 credit - BetterHelp: https://betterhelp.com/lex to get 10% off EPISODE LINKS: Boris's Twitter: https://twitter.com/bsofman Boris's LinkedIn: https://www.linkedin.com/in/bsofman Waymo's Twitter: https://twitter.com/waymo Waymo's YouTube: https://www.youtube.com/waymo Waymo's Website: https://waymo.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:32) - Robots in science fiction (13:13) - Cozmo (38:28) - AI companions (45:23) - Anki (1:10:56) - Waymo Via (1:42:34) - Sensor suites for long haul trucking (1:52:30) - Machine learning (2:10:26) - Waymo vs Tesla (2:21:02) - Safety and risk management (2:30:06) - Societal effects of automation (2:41:11) - Amazon Astro (2:45:35) - Challenges of the robotics industry (2:50:03) - Humanoid robotics (2:57:06) - Advice for getting a PhD in robotics (3:04:37) - Advice for robotics startups (3:15:43) - Advice for students

16 Nov 20213h 20min

Neal Stephenson is a sci-fi writer (Snow Crash, Cryptonomicon, and new book Termination Shock), former Chief Futurist at Magic Leap and first employee of Blue Origin. Please support this podcast by checking out our sponsors: - Mizzen+Main: https://mizzenandmain.com and use code LEX to get $35 off - InsideTracker: https://insidetracker.com/lex and use code Lex25 to get 25% off - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil - Grammarly: https://grammarly.com/lex to get 20% off premium - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free EPISODE LINKS: Neal's Twitter: https://twitter.com/nealstephenson Neal's Website: https://www.nealstephenson.com/ Termination Shock (book): https://amzn.to/3HhmDKi Snow Crash (book): https://amzn.to/3H7yFFW Cryptonomicon (book): https://amzn.to/3C01HDF The Diamond Age (book): https://amzn.to/3wxUF83 Seveneves (book): https://amzn.to/3kkhveg The Baroque Cycle, Vol. 1 (book): https://amzn.to/3koMW7n Innovation Starvation (article): https://bit.ly/3mYLSJ2 PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (08:34) - WWII and human nature (17:20) - Search engine morality (21:58) - Space exploration (38:59) - Aliens and UFOs (47:21) - SpaceX and Blue Origin (54:43) - Social media (59:11) - Climate change (1:11:00) - Consequences of big ideas (1:15:42) - Virtual reality (1:38:50) - Artificial intelligence (1:53:49) - Cryptocurrency (2:06:26) - Writing, storytelling, and books (2:29:05) - Martial arts (2:38:23) - Final thoughts

11 Nov 20212h 47min

Niall Ferguson is a historian at Hoover Institution, Stanford University. He is the author of 16 books on the history of money, war, power, and catastrophe. Please support this podcast by checking out our sponsors: - The Prisoner Wine Company: https://theprisonerwine.com/lex to get 20% off & free shipping - Stripe: https://stripe.com - Coinbase: https://coinbase.com/lex to get $5 in free Bitcoin - Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off - Indeed: https://indeed.com/lex to get $75 credit EPISODE LINKS: Niall's Twitter: https://twitter.com/nfergus Niall's Website: https://www.niallferguson.com University of Austin: https://uaustin.org/ Doom: The Politics of Catastrophe (book): https://amzn.to/3wt7AI8 Kissinger: The Idealist (book): https://amzn.to/3CVXvGc The Ascent of Money (book): https://amzn.to/3kCK0Ev The Square and the Tower (book): https://amzn.to/307YfK8 The Age of AI (book): https://amzn.to/3BUgTSH PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (09:14) - University of Austin (UATX) (42:09) - Sam Harris (1:00:36) - Elon Musk (1:08:55) - Money (1:18:50) - Hyperinflation (1:24:15) - Bitcoin (1:40:57) - Ethereum and smart contracts (1:49:43) - Worst disasters in human history (2:11:41) - How history will remember the current pandemic (2:25:16) - Hope for the future (2:33:46) - Love (2:40:24) - Meaning of life

8 Nov 20212h 48min

Francis Collins is the director of the NIH and former head of the Human Genome Project. Please support this podcast by checking out our sponsors: - Ten Thousand: https://www.tenthousand.cc/ and use code LEX to get 15% off - Allform: https://allform.com/lex to get 20% off - SimpliSafe: https://simplisafe.com/lex and use code LEX to get a free security camera - NI: https://www.ni.com/perspectives - Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off EPISODE LINKS: Francis's Twitter: https://twitter.com/NIHDirector NIH: https://www.nih.gov Human Genome Project: https://www.genome.gov/human-genome-project PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:44) - Lab-leak theory (10:51) - Gain-of-function research of viruses (23:00) - Bioterrorism (27:30) - Tony Fauci (37:41) - COVID Vaccines (43:46) - Joe Rogan (50:49) - Variants (55:31) - Rapid at home testing (59:44) - Animal testing (1:05:09) - Stepping down as director of the NIH (1:09:03) - Barack Obama (1:11:06) - Accelerating Medicines Partnership (1:21:44) - Faith (1:27:12) - Fear of death (1:30:15) - Meaning of life

5 Nov 20211h 33min