#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics

Steve Viscelli is a former truck driver and now an economic sociologist at University of Pennsylvania studying freight transportation, including autonomous trucks. Please support this podcast by checking out our sponsors: - Shopify: https://shopify.com/lex to get 14-day free trial - ROKA: https://roka.com/ and use code LEX to get 20% off your first order - Sunbasket: https://sunbasket.com/lex and use code LEX to get $35 off - Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium - BetterHelp: https://betterhelp.com/lex to get 10% off EPISODE LINKS: Steve's Website: https://www.steveviscelli.com/ Big Rig (book): https://amzn.to/3EbaofP Will Robotic Trucks Be "Sweatshops on Wheels?" (article): https://bit.ly/3vGGgpO Johnny Cash - All I Do Is Drive (song): https://www.youtube.com/watch?v=DEHoagHlqrE Steve's Penn Gazette Interview: https://bit.ly/3nkRPyV More Information on Automated Trucking: http://www.driverlessreport.org/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:36) - Ethnography (19:49) - Challenges of driving a truck (38:28) - Trucking industry: State of affairs (1:11:33) - Future of autonomous trucks (1:37:49) - Solving the automated truck dilemma (2:09:44) - Role of society in automated trucking (2:36:53) - Tesla and revolutionizing the trucking industry (2:56:33) - Hope and final thoughts

3 Nov 20213h 19min

Jimmy Pedro is a judo competitor and coach, world champion, 3x world medalist, 2x Olympic medalist. Please support this podcast by checking out our sponsors: - ROKA: https://roka.com/ and use code LEX to get 20% off your first order - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil - Ladder: https://ladderlife.com/lex - Linode: https://linode.com/lex to get $100 free credit - MasterClass: https://masterclass.com/lex to get 15% off EPISODE LINKS: Jimmy's Instagram: https://www.instagram.com/jimmypedrousa Jimmy's Links: https://linktr.ee/jimmypedro Jimmy's Twitter: https://twitter.com/jimmypedrousa Jimmy's Website: https://www.jimmypedro.com/ American Judo System: https://usajudo.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:56) - The most beautiful throw (32:25) - Russian approach to randori (45:57) - Judo gripping (57:25) - IOC (1:07:50) - Toughest match (1:12:57) - Jimmy Pedro Sr (1:32:12) - Travis Stevens (1:51:42) - Kayla Harrison (2:10:00) - Putin and judo (2:14:12) - Getting started in judo (2:18:58) - BJJ (2:22:24) - Advice for young people

31 Okt 20212h 30min

Michael Mina is an immunologist, epidemiologist, and physician at Harvard. Please support this podcast by checking out our sponsors: - Notion: https://notion.com/startups to get up to $1000 off team plan - Quip: https://getquip.com/lex to get first refill free - Theragun: https://therabody.com/lex to get 30 day trial - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil - Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off EPISODE LINKS: Michael's Twitter: https://twitter.com/michaelmina_lab PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (08:14) - At-home COVID-19 tests (18:17) - Medical devices and FDA classification (24:37) - Rapid test availability (40:59) - Who is in charge of public health? (57:38) - Testing privacy (1:04:54) - Biden's COVID-19 Action Plan (1:16:08) - Uncertainty, fear, and COVID (1:23:02) - Vaccines and herd immunity (1:31:42) - Meditation and consciousness (1:41:44) - Minimalism and Capitalism (1:45:20) - The future of humanity

29 Okt 20211h 53min

Stephen Wolfram is a computer scientist, mathematician, and theoretical physicist. Please support this podcast by checking out our sponsors: - ROKA: https://roka.com/ and use code LEX to get 20% off your first order - FightCamp: https://joinfightcamp.com/lex to get free shipping - Onnit: https://lexfridman.com/onnit to get up to 10% off - Indeed: https://indeed.com/lex to get $75 credit - Fundrise: https://fundrise.com/lex EPISODE LINKS: Stephen's Twitter: https://twitter.com/stephen_wolfram Stephen's Blog: https://writings.stephenwolfram.com Wolfram Physics Project: https://www.wolframphysics.org A New Kind of Science (book): https://amzn.to/30XoEun Fundamental Theory of Physics (book): https://amzn.to/30XbAoT PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:50) - What is complexity (20:51) - Randomness in the universe (25:12) - The Wolfram Physics Project (37:14) - Space and time are discrete (49:19) - Quantum mechanics and hypergraphs (58:33) - What is intelligence (1:09:16) - Computational equivalence (1:17:36) - What it is like to be a cellular automata (1:32:00) - Making prediction vs explanations (1:45:20) - Why does the universe exist (1:51:01) - The universe and rulial space (1:59:44) - Does an atom have consciousness (2:10:10) - Why does our universe exist (2:18:41) - What is outside the ruliad (2:29:15) - Automated proof systems (2:45:10) - Multicomputation for biology (3:03:41) - Cardano NFT collaboration with Wolfram Alpha (3:10:41) - Global theory of economics

27 Okt 20213h 45min

Carl Hart is a psychologist at Columbia University. Please support this podcast by checking out our sponsors: - InsideTracker: https://insidetracker.com/lex and use code Lex25 to get 25% off - Ten Thousand: https://www.tenthousand.cc/ and use code LEX to get 15% off - Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free EPISODE LINKS: Carl's Twitter: https://twitter.com/drcarlhart Carl's Website: https://drcarlhart.com Drug Use for Grown-Ups (book): https://amzn.to/3lVpq2Y PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:33) - The experience of drugs (18:38) - Drug use for grownups (24:21) - Studies on drugs (25:31) - Negative effects of drugs (30:59) - Should all drugs be legalized (36:27) - War on drugs: positive or negative (42:19) - Proper, positive, and misuse of drugs (46:40) - Recovery (53:34) - Drug depiction in movies (57:05) - How the study of drugs changed Carl (59:28) - Formative memories (1:03:57) - Greatest hip hop artist of all time (1:07:19) - What mind altering drugs teach us (1:11:26) - Advice for young people (1:13:31) - The meaning of life

23 Okt 20211h 16min

Brian Greene is a theoretical physicist. Please support this podcast by checking out our sponsors: - The Prisoner Wine Company: https://theprisonerwine.com/lex to get 20% off & free shipping - Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium - LMNT: https://drinkLMNT.com/lex to get free sample pack - BetterHelp: https://betterhelp.com/lex to get 10% off - NI: https://www.ni.com/perspectives EPISODE LINKS: Brian's Twitter: https://twitter.com/bgreene Brian's Website: http://www.briangreene.org/ Until the End of Time (book): https://amzn.to/2XuqXUi PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (06:53) - Entropy (15:01) - Consciousness (31:20) - Quantum gravity (34:40) - String theory (48:07) - Time (1:00:39) - Free will (1:05:02) - Emergence and complexity (1:12:14) - The Big Bang (1:25:13) - Extraterrestrial life (1:35:35) - Space exploration (1:43:33) - Fear of death

20 Okt 20211h 52min

Alex Gladstein is the Chief Strategy Officer at the Human Rights Foundation and the Oslo Freedom Forum. Please support this podcast by checking out our sponsors: - Stripe: https://stripe.com - Paperspace: https://gradient.run/lex to get $15 credit - Codecademy: https://codecademy.com and use code LEX to get 15% off - NI: https://www.ni.com/perspectives - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings EPISODE LINKS: Alex's Twitter: https://twitter.com/gladstein The Little Bitcoin Book: https://littlebitcoinbook.com/ Human Rights Foundation: https://hrf.org/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (08:36) - Universal human rights (22:35) - Authoritarianism (32:46) - AIs impact on civil liberties (44:09) - Edward Snowden and government surveillance (47:48) - Money (52:01) - Bitcoin (1:07:48) - Government response to Bitcoin (1:18:19) - The blockchain (1:23:42) - Can Bitcoin fail? (1:26:33) - Bitcoin scams (1:30:17) - Patriotism (1:32:41) - Human Rights Foundation (1:37:15) - Conflict with China (1:40:05) - Corporate accountability (1:55:27) - Garry Kasparov and the HRF (2:00:36) - Journalism, conversations, and truth (2:07:50) - Alex's book recommendations (2:15:56) - Attacks on Bitcoin (2:17:35) - The future of humanity (2:21:57) - Advice for young people (2:33:13) - Meaning of life

16 Okt 20212h 40min

Kelsi Sheren is a veteran, artillery gunner, and founder of Brass and Unity. Please support this podcast by checking out our sponsors: - Shopify: https://shopify.com/lex to get 14-day free trial - Justworks: https://justworks.com - Novo: https://banknovo.com/lex - Indeed: https://indeed.com/lex to get $75 credit - Onnit: https://lexfridman.com/onnit to get up to 10% off EPISODE LINKS: Kelsi's Twitter: https://twitter.com/kelsiburns Kelsi's Website: https://brassandunity.com Kelsi's Instagram: https://www.instagram.com/kelsie_sheren Charity: https://www.heroicheartsproject.org/ Do the F*cking Work (book): https://amzn.to/3mGhguF Notes from Underground (book): https://amzn.to/3mN5TRF Brothers in Arms (song): https://www.youtube.com/watch?v=jhdFe3evXpk PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:50) - World War II (18:54) - Yeonmi Park, starvation, and mental health (33:10) - Kelsi's 9/11 experience (36:39) - Becoming a soldier (43:07) - Artillery: The Hand of God (52:49) - Weapons training (1:10:35) - Pre-Deployment (1:26:42) - Arrival to Afghanistan (1:48:55) - Tragic war story (2:13:59) - Feelings after tragedy (2:17:41) - The Taliban (2:23:17) - Retrospective: 20 years in Afghanistan (2:39:57) - How war changes people (2:45:18) - PTSD (3:14:13) - Ayahuasca and mental recovery (3:46:09) - Love (4:04:12) - Advice for young people (4:07:33) - Death (4:13:22) - World War II

14 Okt 20210s