#551: Stroll Down Startup Lane - 2026

#551: Stroll Down Startup Lane - 2026

If you've ever been to PyCon, you know one of the best parts of the expo hall is Startup Row, a stretch of booths where early-stage companies built on Python show off what they're creating. But only attendees get to walk that lane, so let's bring it to everyone. In this episode, we stroll down Startup Row together. We kick things off with the organizers, Jason and Shay, who share the program's origin story going back to Paul Graham and the PSF, plus some surprising stats, including two unicorns among the alumni. Then we meet five startups: Tetrix, bringing AI to institutional investing in private markets. Arcjet, security that lives inside your app as an SDK. Phemeral.dev, serverless hosting built for Python web apps. CapiscIO, an identity and authority layer for AI agents. And Pixeltable, a multimodal database from Marcel Kornacker, co-creator of Apache Parquet. See if you can spot the theme running through them all. Let's go for a walk.

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Episoder(551)

#552: Astral joins OpenAI

#552: Astral joins OpenAI

OpenAI just acquired Astral, the company behind uv, Ruff, and ty. And if your first thought was "wait, is uv toast?", you are not alone. But here's the twist Charlie Marsh shared with me: he thinks th...

17 Jun 1h 5min

#550: AI Contributions and Maintainer Load in Open Source

#550: AI Contributions and Maintainer Load in Open Source

You wake up, brew the coffee, open GitHub, and there it is. Another pull request on your open source project. Thirteen thousand lines added. No issue filed first. No discussion. Just "here, please rev...

30 Mai 1h 2min

#549: Great Docs

#549: Great Docs

Your documentation has two audiences now - humans reading the rendered HTML, and AI agents trying to make sense of your library. Rich Iannone and Michael Chow from Posit are back on Talk Python with a...

25 Mai 1h 7min

#548: Event Sourcing Design Pattern

#548: Event Sourcing Design Pattern

What if your database worked more like Git? Every change captured as an immutable event you can replay, instead of a single mutating row that quietly forgets its own history. That's event sourcing, an...

11 Mai 1h 8min

#547: Parallel Python at Anyscale with Ray

#547: Parallel Python at Anyscale with Ray

When OpenAI trained GPT-3, they didn't roll their own orchestration layer. They used Ray, an open source Python framework born out of the same Berkeley research lab lineage that gave us Apache Spark. ...

6 Mai 59min

#546: Self hosting apps for Python people

#546: Self hosting apps for Python people

The cloud is convenient until it isn't. You upload your photos, sync your contacts, click through the cookie banners. Then prices go up again or you read about a family that lost their entire Google a...

27 Apr 1h 3min

#545: OWASP Top 10 (2025 List) for Python Devs

#545: OWASP Top 10 (2025 List) for Python Devs

The OWASP Top 10 just got a fresh update, and there are some big changes: supply chain attacks, exceptional condition handling, and more. Tanya Janca is back on Talk Python to walk us through every si...

16 Apr 1h 6min

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