#379 Global Cancer Diagnostics: Building High-Quality Cancer Genomic Testing

As we approach World Cancer Day on February 4th, this episode of DNA Today takes a global look at how cancer diagnostics are evolving, not just in research settings, but in real-world clinical laboratories where innovation must meet reliability, scalability, and patient impact.

In this conversation, we bring together three experts from around the world working at the intersection of oncology diagnostics, sequencing technology, and clinical implementation.

Joining us from Portugal is Dr. Jorge Lima of IPATIMUP, one of Europe’s leading oncology centers known for its research-driven diagnostic mission. From Italy, Bernard Okere joins us as a Field Application Scientist at MGI Tech, a company providing a full spectrum of sequencing platforms and automation solutions for life science and clinical laboratories worldwide. And from China, we’re joined by Nancy Yang, International Senior Business Development Manager at Gene+, a genetic testing and precision oncology company behind one of the largest oncology gene panels currently in clinical use.

Together, we explore how IPATIMUP has implemented large-scale DNA and RNA sequencing, including Gene+’s 1,021-gene DNA panel and RNA sequencing, to expand diagnostic confidence while maintaining rigorous clinical standards. This episode dives into validation, automation, workflow design, and cross-company partnerships, offering a behind-the-scenes look at how modern oncology labs grow without compromising quality.

In This Episode, We Discuss Setting the Stage: IPATIMUP’s Role in Oncology

• How IPATIMUP fits into Europe’s oncology landscape
• Why a research-driven approach is central to its diagnostic mission

From Research to Routine Diagnostics

• Translating research findings into clinical workflows
• Balancing innovation with responsibility in patient-facing diagnostics

Choosing the Right Technology Partner

• Why IPATIMUP selected MGI sequencing platforms
• What differentiates MGI’s technology in oncology applications
• The importance of flexibility across DNA and RNA testing
• Why long-term technical collaboration matters beyond installation

Large Gene Panels in Clinical Practice

• How Gene+ selected the 1,021 genes included in its oncology panel
• Real-world experience using large DNA and RNA panels in routine diagnostics
• Why the Gene+ panel pairs effectively with MGI’s sequencing platforms
• What it takes to move from validation to clinical implementation

RNA Sequencing as a Diagnostic Advantage

• How RNA sequencing complements DNA-based testing in oncology
• When RNA sequencing provides the most clinical value
• How RNA data can increase diagnostic confidence in complex cases

Automation, Scale, and Quality

• Why automation is essential for high-throughput oncology labs
• Reducing hands-on time and minimizing human error
• Practical advice for labs looking to scale while maintaining consistency and quality

Relevant Resources:

• IPATIMUP
• MGI Tech
• MGI’s Sequencing Platforms
• Gene+ (Website currently under construction)

Relevant DNA Today Podcast Episode:

#355 How Genomics Is Transforming Rare Disease Diagnosis in Turkey with MGI Tech

#360 Hereditary Breast Cancer on the Big Screen with “Love, Danielle”

#364 Breast Cancer Genetic Testing in Italy: A Curated Gene Panel

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