Epigenetics - The Medicine Nobody Told You About4 Aug

Season 2, Episode 4: The Journey Of A Single Marker

Today we do something different. We follow a single molecule on its actual journey, from a leaf of spinach growing in a field, through your gut wall, through your liver, through an enzyme called MTHFR that you may have heard about from genetic testing, into a single cell, all the way to a specific spot on a specific gene where it silences the gene it was made to silence.

The journey is real. It is happening, in some version, in your body right now, trillions of times a second, with the molecules from the food you ate yesterday and this morning. And in most modern adults, the journey is failing at at least one point. Often at several. This episode shows you where those failure points are and what the pathway actually needs to run at full speed.

If your blood work is normal but your energy is not, if your mood swings without obvious cause, if you carry unexplained fatigue that no doctor has been able to name, this is the episode that may explain it.

Free download with this episode: Nutrients Almost Every Westerner Is Low In. A practical reference with the nutrients that support methylation, the best food sources, and notes on supplementation. For a personal conversation about your own methylation and where to start.

Sources

Choi, S. W. et al. - Modulation of DNA Methylation by One-Carbon Metabolism https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375321/

Raghubeer, S. et al. - Methylenetetrahydrofolate Reductase, the One-Carbon Cycle, and Disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703276/

Crider, K. S. et al. - Folate and DNA Methylation: A Review of Molecular Mechanisms and the Evidence for Folate’s Role https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262611/

Stover, P. J. - One-Carbon Metabolism–Genome Interactions in Folate-Associated Pathologies https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777484/

Ben Lynch - Dirty Genes https://www.harpercollins.com/products/dirty-genes-ben-lynch

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Episoder(18)

Season 3, Episode 1: When The Immune System Fights The Wrong Thing

In this episode, I open the season with a fundamental question: why does the immune system, designed to protect us, sometimes turn on the body itself? I explain molecular mimicry, the case of mistaken...

6 Okt 23min

Season 2, Episode 11: The Epigenetic Lens, And A Bridge To What Is Next

In this final episode of the season, I bring the conversation together. Over the season, we have looked at genes, methylation, food, sleep, movement, stress, environmental load, relationships, and the...

22 Sep 25min

Season 2, Episode 10: When Your Relationships Live Inside Your Cells

In this episode, I talk about the biological power of relationships. I look at loneliness, social isolation, belonging, marital conflict, community, and the way our social environment can reach the im...

15 Sep 45min

Season 2, Episode 9: The Load You Are Carrying Without Knowing It

In this episode, I talk about environmental load - not in a dramatic or moralizing way, but as a practical biological reality. I explain how small daily exposures can accumulate through air, water, fo...

8 Sep 49min

Season 2, Episode 8: Three Generations, And What Their Bodies Were Asked To Do

In this episode, I compare three generations of bodies: our grandmothers, our mothers, and us. I talk about how daily life used to contain continuous, varied, unconscious movement - carrying, walking,...

1 Sep 41min

Season 2, Episode 7: Food: The Information You Eat Three Times A Day

In this episode, I talk about food not only as fuel, but as information. I look at how modern food has changed: nutrient density, processing, additives, pesticides, packaging, ultra-processed foods, a...

25 Aug 49min

Season 2, Episode 6: A Journey Through A Single Night

In this episode, I take you through one night of sleep, hour by hour. I talk about sleep as one of the most active biological states of the body: a time for memory consolidation, hormonal regulation, ...

18 Aug 31min

Season 2, Episode 5: Three Ways Stress Lives In A Body

In this episode, I talk about stress not as a vague feeling, but as biology. I describe three different stress patterns I have seen again and again: the high-functioning achiever who cannot feel the c...

11 Aug 33min