Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

At supraphysiological dosages, taking GH before going to sleep makes sense because there is a negative feedback loop on the growth hormone (GH)/insulin-like growth factor I (IGF-1) axis. In this study, IGF-1 was constantly infused, and the effect on endogenous GH secretion was assessed [R]. Overall, GH concentrations were suppressed during the rhIGF-I infusion by 85±3%, mainly by attenuating spontaneous GH pulse amplitude (77±4% suppression). The apparent GH pulse frequency was attenuated from 7.8±0.9 to 4.7±0.6 pulses/24h (P= 0.006). IGF-1 is the primary feedback, and the mechanism is similar to what you see with the HPTA axis. When there is enough Testosterone and Estrogen, your body has this mechanism in place to prevent you from making more. The same thing happens with exogenous GH use. When you administer exogenous GH, IGF-1 elevates. When your body recognizes that IGF-1 is elevated, it starts to suppress GH pulse amplitude in a dose dependent manner. If you are using supraphysiological amounts of GH for bodybuilding purposes, you can assume that your natural secretion is greatly inhibited during sleep as this negative feedback loop will prevent your body from secreting GH in your sleep like it normally would. When endogenous GH production is suppressed, administering exogenous GH at times that lipolysis or muscle growth can be optimized is the most logical approach to injection timing. https://youtu.be/8j9MGfQPeXg If fat loss is the goal, then taking GH in a fasted state prior to fasted cardio would be ideal. There is a ceiling on how much GH is needed to maximize lipolysis, so if your dosage exceeds 2 IU per day, then I would advise splitting up that dose into two (or more if needed) different periods of the day with as much time between them as possible. If muscle growth is the goal, GH should still be administered in a pulsatile fashion to mimic endogenous secretions. Topped out stimulation of autocrine IGF-1 in skeletal muscle can be achieved with fairly low dosages of exogenous GH, and administering a higher dose above and beyond that may just be a waste. This is why it would be wise to split up your daily GH dose into multiple administrations if you are using supraphysiological dosages. Learn more about your ad choices. Visit megaphone.fm/adchoices

Episoder(1360)

Keeping Your Hair Vs Gaining More Muscle With Androgenic Steroids

Keeping Your Hair Vs Gaining More Muscle With Androgenic Steroids

Bodybuilding To Get Women Vs Bodybuilding To Compete In this day and age of social media, if you follow bodybuilding you probably follow a lot of fitness models, as well as people who compete in physique, classic physique, or bodybuilding. Using these social media presences as inspiration creates an illusion that the ideal physique for men is 200 pounds diced as a minimum, and that men's physique competitors are likely the minimum level of muscularity necessary for a maxed out physique.… Learn more about your ad choices. Visit megaphone.fm/adchoices

28 Des 201811min

Proving With Blood Work That Testosterone Also Causes Hair Loss – Not Just DHT

Proving With Blood Work That Testosterone Also Causes Hair Loss – Not Just DHT

Testosterone Also Causes Hair Loss – Not Just DHT I see A LOT of misinformation on the Internet in regards to hair loss (male pattern baldness/androgenic alopecia). Especially when it comes to why it occurs on a hormonal level, and the mechanism of action behind what is actually happening to your hair follicles.… Learn more about your ad choices. Visit megaphone.fm/adchoices

10 Des 201825min

How Much Time Should You Take Off Between Steroid Cycles After PCT

How Much Time Should You Take Off Between Steroid Cycles After PCT

Does time on = time off? How much time should I take off after a steroid cycle after PCT? I get these kind of questions all the time. Regardless of what suppressive anabolics you were on (SARMs, AAS, Prohormones, etc.) PCT is a necessity.… Learn more about your ad choices. Visit megaphone.fm/adchoices

29 Jun 20184min

SARMs Liquid Vs Capsules – Which Is More Potent? (Myth Busted)

SARMs Liquid Vs Capsules – Which Is More Potent? (Myth Busted)

SARMs Liquid Vs Capsules There is a lot of confusion regarding which is more effective, SARMs Liquid Vs Capsules. There are several ridiculous theories and false statements thrown around the community purporting that liquid SARMs are more effective than capsules/pills, and most of the time these statements are simply deriving from misinformed individuals, or those who have vested interest in the profitability of liquid SARMs (AKA they own/work for/are paid by a company who sells liquid SARMs).… Learn more about your ad choices. Visit megaphone.fm/adchoices

27 Jan 20184min

Can SARMs Cause Gyno? – Revealing How SARMs Can Cause Gynecomastia & How To Protect Yourself

Can SARMs Cause Gyno? – Revealing How SARMs Can Cause Gynecomastia & How To Protect Yourself

Can SARMs Cause Gyno? One very common question I get asked is about SARMs and high Estrogen side effects. One of the biggest myths circulating in the community is that SARMs cannot cause Estrogen related side effects because they don’t aromatize into Estrogen, and if you do experience high Estrogen side effects then you have “fake SARMs” or “Prohormone laced SARMs.”… Learn more about your ad choices. Visit megaphone.fm/adchoices

19 Jan 20182min

S23 SARM Overview – Preclinical Profile, Results, Reviews & Side Effects

S23 SARM Overview – Preclinical Profile, Results, Reviews & Side Effects

S23 is undoubtedly one of the strongest SARMs in development right now. It has an extremely high binding affinity, is very suppressive, and is a very potent muscle builder with a high level of tissue selectivity relative to anabolic androgenic steroids.… Learn more about your ad choices. Visit megaphone.fm/adchoices

13 Jun 201731min

GH Gut In Bodybuilding – What Causes It?

GH Gut In Bodybuilding – What Causes It?

There is a belief that is widespread in the bodybuilding community that using HGH, MK-677, or other GH releasing peptides will cause your intestines to grow, start protruding outwards, consequently giving a very unaesthetic distended look of the abdominals known as GH gut.… Learn more about your ad choices. Visit megaphone.fm/adchoices

21 Mar 201714min

YK11 Myostatin Inhibitor – Increased Follistatin, Results & Side Effects

YK11 Myostatin Inhibitor – Increased Follistatin, Results & Side Effects

YK11 is theorized to allow bodybuilders to inhibit the feedback loop in their body that limits how much muscle they can pack on via Myostatin inhibition. The end result of this could be increased muscle growth potential that would otherwise be impossible to achieve.… Learn more about your ad choices. Visit megaphone.fm/adchoices

24 Nov 201618min

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