Epigenetics & Glioblastoma: New Approaches to Treat Brain Cancer (Lucy Stead)

Epigenetics & Glioblastoma: New Approaches to Treat Brain Cancer (Lucy Stead)

In this Episode of the Epigenetics Podcast our guest Lucy Stead from the University of Leeds provides insight into her work on intratumor heterogeneity in Glioblastoma. In order to tackle this area she uses an holistic approach including Computational Genomics, In silico Modeling and Functional Genomics in order to test whether treatment-resistant subclones emerge in recurrent tumors, and characterize them in clinically relevant ways in multiple patients. And this is just a glimpse of what is discussed in this Episode.

References

  • Lucy F. Stead, Helene Thygesen, … Pamela Rabbitts (2015) Using common variants to indicate cancer genes (International Journal of Cancer) DOI: 10.1002/ijc.28951
  • Caroline Conway, Jennifer L. Graham, … Lucy F. Stead (2015) Elucidating drivers of oral epithelial dysplasia formation and malignant transformation to cancer using RNAseq (Oncotarget) DOI: 10.18632/oncotarget.5529
  • Alastair Droop, Alexander Bruns, … Lucy F. Stead (2018) How to analyse the spatiotemporal tumour samples needed to investigate cancer evolution: A case study using paired primary and recurrent glioblastoma (International Journal of Cancer) DOI: 10.1002/ijc.31184
  • Georgette Tanner, David R. Westhead, … Lucy F. Stead (2019) Simulation of heterogeneous tumour genomes with HeteroGenesis and in silico whole exome sequencing (Bioinformatics (Oxford, England)) DOI: 10.1093/bioinformatics/bty1063
  • Nora Rippaus, Alexander F-Bruns, … Lucy F. Stead (2019) JARID2 facilitates transcriptional reprogramming in glioblastoma in response to standard treatment (bioRxiv) DOI: 10.1101/649400

Contact

Episoder(169)

The Impact of Chromatin Architecture on Alzheimer's and Parkinson's Disease (Ryan Corces)

The Impact of Chromatin Architecture on Alzheimer's and Parkinson's Disease (Ryan Corces)

In this episode of the Epigenetics Podcast, we talked with Ryan Corces from the Gladstone Institutes about his work on the impact of chromatin architecture on Alzheimer's and Parkinson's Disease. The...

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RNA-Mediated Epigenetic Regulation (Mo Motamedi)

RNA-Mediated Epigenetic Regulation (Mo Motamedi)

In this episode of the Epigenetics Podcast, we talked with Mo Motamedi from the Center for Cancer Research at Massachusetts General Hospital about his work on RNA-mediated epigenetic regulation. The I...

2 Okt 202545min

Evolutionary Forces Shaping Mammalian Gene Regulation (Emily Wong)

Evolutionary Forces Shaping Mammalian Gene Regulation (Emily Wong)

In this episode of the Epigenetics Podcast, we talked with Emily Wong from the University of New South Wales in Sydney about her work on how evolution shapes mammalian genes. As the head of the Regula...

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Chromatin Evolution (Arnau Sebé-Pedrós)

Chromatin Evolution (Arnau Sebé-Pedrós)

In this episode of the Epigenetics Podcast, we talked with Arnau Sebé-Pedrós from the Center for Genomic Regulation in Barcelona about his work on chromatin evolution. The Interview starts by examinin...

4 Sep 202546min

Epigenetic Mechanisms in Breast Cancer (Luca Magnani)

Epigenetic Mechanisms in Breast Cancer (Luca Magnani)

In this episode of the Epigenetics Podcast, we talked with Luca Magnani from Institute of Cancer Research and UNIMI in Milan about his work on epigenetic mechanisms of drug resistance and cancer cell ...

21 Aug 202537min

How BRD4 and H2BE Influence Neuronal Activity (Erica Korb)

How BRD4 and H2BE Influence Neuronal Activity (Erica Korb)

In this episode of the Epigenetics Podcast, we talked with Erica Korb from the University of Pennsylvania about her work on BRD4 and the histone variant H2BE, which influences synaptic genes and neuro...

7 Aug 202537min

Mapping the Epigenome: From Arabidopsis to the Human Brain (Joseph Ecker)

Mapping the Epigenome: From Arabidopsis to the Human Brain (Joseph Ecker)

In this episode of the Epigenetics Podcast, we talked with Dr. Joseph Ecker from the Salk Institute about his work on high-resolution genome-wide mapping technologies, specifically how the regulation ...

24 Jul 202544min

The Human Cell Atlas (Sarah Teichmann)

The Human Cell Atlas (Sarah Teichmann)

In this episode of the Epigenetics Podcast, we talked with Sarah Teichmann from the University of Cambridge about the Human Cell Atlas. In the Interview we explore Sarah Teichmann's impressive career ...

10 Jul 202546min

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