Epigenetics & Glioblastoma: New Approaches to Treat Brain Cancer (Lucy Stead)

Epigenetics & Glioblastoma: New Approaches to Treat Brain Cancer (Lucy Stead)

In this Episode of the Epigenetics Podcast our guest Lucy Stead from the University of Leeds provides insight into her work on intratumor heterogeneity in Glioblastoma. In order to tackle this area she uses an holistic approach including Computational Genomics, In silico Modeling and Functional Genomics in order to test whether treatment-resistant subclones emerge in recurrent tumors, and characterize them in clinically relevant ways in multiple patients. And this is just a glimpse of what is discussed in this Episode.

References

  • Lucy F. Stead, Helene Thygesen, … Pamela Rabbitts (2015) Using common variants to indicate cancer genes (International Journal of Cancer) DOI: 10.1002/ijc.28951
  • Caroline Conway, Jennifer L. Graham, … Lucy F. Stead (2015) Elucidating drivers of oral epithelial dysplasia formation and malignant transformation to cancer using RNAseq (Oncotarget) DOI: 10.18632/oncotarget.5529
  • Alastair Droop, Alexander Bruns, … Lucy F. Stead (2018) How to analyse the spatiotemporal tumour samples needed to investigate cancer evolution: A case study using paired primary and recurrent glioblastoma (International Journal of Cancer) DOI: 10.1002/ijc.31184
  • Georgette Tanner, David R. Westhead, … Lucy F. Stead (2019) Simulation of heterogeneous tumour genomes with HeteroGenesis and in silico whole exome sequencing (Bioinformatics (Oxford, England)) DOI: 10.1093/bioinformatics/bty1063
  • Nora Rippaus, Alexander F-Bruns, … Lucy F. Stead (2019) JARID2 facilitates transcriptional reprogramming in glioblastoma in response to standard treatment (bioRxiv) DOI: 10.1101/649400

Contact

Episoder(173)

Evolutionary Epigenetic Clocks and Epigenetic Inheritance in Plants (Frank Johannes)

Evolutionary Epigenetic Clocks and Epigenetic Inheritance in Plants (Frank Johannes)

In this episode of the Epigenetics Podcast, we talked with Dr. Frank Johannes from the Technical University of Munich in Freising about his work on evolutionary clocks and epigenetic inheritance in pl...

24 Apr 202539min

Neuroepigenetic Mechanisms and Primate Epigenome Evolution (Boyan Bonev)

Neuroepigenetic Mechanisms and Primate Epigenome Evolution (Boyan Bonev)

In this episode of the Epigenetics Podcast, we talked with Boyan Bonev from the HelmholtzZetrum in Munich about his work on neuroepigenetics, focusing on gene regulation, chromatin architecture, and p...

10 Apr 202545min

The Role of H3K4me3 in Embryonic Development (Eva Hörmanseder)

The Role of H3K4me3 in Embryonic Development (Eva Hörmanseder)

In this episode of the Epigenetics Podcast, we talked with Dr. Eva Hörmanseder from the HelmholtzZentrum in Munich about her work on epigenetic mechanisms in cellular memory and gene regulation. In th...

27 Mar 202537min

Using RICC-Seq to Probe Short Range Chromatin Folding (Viviana Risca)

Using RICC-Seq to Probe Short Range Chromatin Folding (Viviana Risca)

In this episode of the Epigenetics Podcast, we talked with Viviana Risca from Rockefeller University about her work on RICC-Seq and how it's used to probe DNA-DNA contacts in intact or fixed cells usi...

13 Mar 202546min

The Mechanism of ATP-dependent Remodelers and HP1 Gene Silencing (Geeta Narlikar)

The Mechanism of ATP-dependent Remodelers and HP1 Gene Silencing (Geeta Narlikar)

In this episode of the Epigenetics Podcast, we talked with Geeta Narlikar from UCSF about her work on chromatin remodeling, Heterochromatin Protein 1, and the molecular mechanisms that influence the g...

27 Feb 202539min

Polycomb Proteins, Gene Regulation, and Genome Organization in Drosophila (Giacomo Cavalli)

Polycomb Proteins, Gene Regulation, and Genome Organization in Drosophila (Giacomo Cavalli)

In this episode of the Epigenetics Podcast, we talked with Giacomo Cavalli from the Institute of Human Genetics in Montpellier about his work on critical aspects of epigenetic regulation, particularly...

13 Feb 202544min

The Interplay of Nutrition, Metabolic Pathways, and Epigenetic Regulation (Ferdinand von Meyenn)

The Interplay of Nutrition, Metabolic Pathways, and Epigenetic Regulation (Ferdinand von Meyenn)

In this episode of the Epigenetics Podcast, we talked with Ferdinand von Meyenn from ETH Zürich about his work on the interplay of nutrition, metabolic pathways, and epigenetic regulation. To start Dr...

23 Jan 202548min

Single-Molecule Adenine Methylated Oligonucleosome Sequencing Assay (SAMOSA) (Vijay Ramani)

Single-Molecule Adenine Methylated Oligonucleosome Sequencing Assay (SAMOSA) (Vijay Ramani)

In this episode of the Epigenetics Podcast, we talked with Vijay Ramani from the Gladstone Institute about his work on Single-Molecule Adenine Methylated Oligonucleosome Sequencing Assay (SAMOSA). Our...

9 Jan 202552min

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