The Dirty Secret Behind Ozempic: How It Wrecks Your Gut (Here’s How to Fix It) | Hannah Kleinfeld  : 1265

The Dirty Secret Behind Ozempic: How It Wrecks Your Gut (Here’s How to Fix It) | Hannah Kleinfeld : 1265

For decades, gut health was reduced to yogurt commercials and vague promises from probiotics that barely worked. But what if we’ve been targeting the wrong bugs, using the wrong delivery, and ignoring the true source of chronic inflammation and accelerated aging?

In this thought-provoking episode, Dave sits down with Hannah Kleinfeld, a leader in microbiome innovation, to expose why most probiotics fail—and how one company’s scientifically validated approach could redefine your gut, brain, immune system, and even your metabolism.

You’ll learn how dysbiosis may be wrecking your brain without you knowing it, why your probiotic likely died in your stomach acid, and the secret to rebooting your microbiome after antibiotics, GLP-1 drugs, or years of toxic exposure. This isn’t just about digestion—your gut controls your cravings, energy, sleep, mood, and aging trajectory.

So what’s the one upgrade that can actually reset your gut… for good?

What You’ll Learn in This Episode:

• Why your gut—not your brain—is making most of your decisions

• How 93% of probiotics on the market fail before they reach your intestines

• The “AB 10” protocol that rebuilds your gut after antibiotics or SIBO

• What GLP-1 weight-loss drugs are doing to your microbiome (and how to stop it)

• The shocking gut–brain–heart axis connection you’ve never heard of

• Why inflammation, brain fog, and mood swings may start with leaky gut

• Which probiotic strains are clinically proven to improve cognition and mood

• What to do if you want to eat gluten again—or survive American wheat

• How a fermented papaya concentrate could replace your acid reflux meds

• Why optimizing your gut could extend your lifespan by 40%


***Get 20% off your next purchase by going to https://omnibioticlife.com/pages/dave-asprey/ or omnibioticlife.com/dave***

SPONSORS

-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.

-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.

Resources:

Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

OMNi-BiOTiC's Instagramhttps://www.instagram.com/fatty15/

OMNi-BiOTiC's Website: https://omnibioticlife.com/

2025 Biohacking Conference: https://biohackingconference.com/2025

Danger Coffee: https://dangercoffee.com

Dave Asprey’s Website: https://daveasprey.com

Dave Asprey’s Linktree: https://linktr.ee/daveasprey

Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

Own an Upgrade Labs: https://ownanupgradelabs.com

Upgrade Labs: https://upgradelabs.com

40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com


Timestamps:

00:00 – Trailer

03:15 – Intro

05:05 – Probiotics, Prebiotics, and Postbiotics Explained

08:21 – The Importance of Delivery Mechanisms

17:36 – Addressing SIBO and Gut Health Protocols

31:55 – The Impact of GLP-1 Drugs on Gut Health

39:26 – The Role of Gut Bacteria in Hunger and Fasting

40:01 – Painkillers and Gut Health: A Personal Experience

40:51 – The Dangers of Proton Pump Inhibitors

42:00 – The Importance of Stomach Acid

44:55 – Probiotics for Chronic Conditions

48:38 – The Impact of Glyphosate on Gut Health

57:04 – Alcohol and Gut Bacteria

01:02:01 – New Solutions for Acid Reflux

01:07:57 – The Future of Gut Health and Longevity

01:11:33 – Conclusion and Special Offer

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Episoder(1430)

How Brain Training Changes Your Frequency – Dr. Patrick Porter : 984

How Brain Training Changes Your Frequency – Dr. Patrick Porter : 984

(BrainTap® sponsored this episode.)IN THIS EPISODE OF THE HUMAN UPGRADE™… brain expert Patrick Porter, Ph.D., joins Dave at the 8th Annual Biohacking Conference in Beverly Hills to talk about training your brain. Dr. Porter pioneered the use of brainwave entrainment with a technology-enhanced meditation device called BrainTap.Whether you’re a newbie, a hard-core devotee or somewhere in the middle of your biohacking journey, you already focus on body exercise and nutrition. You probably manage your stress and mental health, too. It’s all training of some sort, which is where BrainTap comes in. It’s a specific kind of training for your brain.New discoveries in science reveal that you can form new neurons in your brain, called neurogenesis. Your brain state isn’t fixed! And then there’s neuroplasticity, a process of adaptive structural and functional changes to the brain that involves connections to your nervous system.BrainTap’s unique technology uses light, sound and vibration to train and regulate your brain for relaxation, sleep, performance, weight loss, aging and more. To get to a higher personal frequency on the regular, you want to achieve coherence.Since Dr. Porter specializes in the science of calming the brain, you’ll find out how you can manage your physiological and mental health in today’s super stressed-out world. You’ll also learn how impact remote work, remote learning and pandemic isolation impacted brain health and memory.This conversation gets into some of BrainTap’s exciting research with aging populations and elite athletes. too.SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: https://braintap.com/daveWE APPRECIATE OUR PARTNERS. CHECK THEM OUT! Isometrics for Cardiovascular Health: https://www.zona.com, use code DAVE2022 to get $150 off the Zona PlusMattress Temperature Tech: https://www.eightsleep.com/dave, use code dave to save $250 on the Pod ProA Cleaner Nicotine Alternative: https://lucy.co, use code DAVE20 for 20% off your first order of pouches, gums or lozengesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Okt 202253min

How to Eat Smarter and Trigger Your Metabolic Switches – Shawn Stevenson  : 983

How to Eat Smarter and Trigger Your Metabolic Switches – Shawn Stevenson : 983

IN THIS EPISODE OF THE HUMAN UPGRADE™… you’ll learn how you can make smarter food choices to support your metabolic energy and upgrade your brain. You’ll also find out some new things about body fat. For example, did you know that it’s a complex organ that communicates throughout your entire body system? You’ll get tips on fat loss essentials and how to use them to your advantage. Today’s guest, Shawn Stevenson, hosts a popular podcast called The Model Health Show. He’s a nutritionist, researcher and bestselling author with education and experience in business, biology, and nutritional science.Shawn’s been in the health and wellness space and doing clinical work as a nutritionist for nearly two decades. He’s known for his ability to keep learning and evolving his approach with deep research into the science of human health.He’s all about improving human performance and energy with science-backed basics like food in his “Eat Smarter” book and sleep in his “Sleep Smarter“ book. This episode gets right into food choices you can make—and why they work—to stoke your metabolic energy. Topics like:How people can better understand the process of fat loss.How the misconstrued science of calories contributes to how much people struggle with their diets.What metabolic switches are, what do they do, and why it’s important for you to know how to turn them on and off.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT! Custom Silver for Health & Healing: https://tru47.com/dave, use code DAVE20 to get 20% off for a limited timeCustomized Nootropics for Your Own Neurochemistry: https://nootopia.com/dave, use code DAVE10 to get 10% offBusiness Growth With SEO: https://www.stephanspencer.com, get a FREE consultationSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Okt 202254min

Mini-Episode: Cool Facts Friday #27

Mini-Episode: Cool Facts Friday #27

In this Episode of The Human Upgrade™...​Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.• Saving your poop may save your microbiome• Insults trigger a mini slap in the face• Young cerebral spinal fluid supports memory in aging brains• The distinct role your nose plays in your friendshipsEPISODE SPONSOR: Get Fit in Five Minutes: Go to https://www.carolbike.com. Use code HumanUpgrade to get 2 years of free membership (a total savings of $360). CAROL Bike also offers a 100-day home trial of the CAROL Bike 2.0. Learn more: How to Hack Your Cardio Workout – Ulrich Dempfle– #978.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

30 Sep 202210min

How Butyrate Supports Gut, Cell & Brain Function – Jessica Kane Berman : 982

How Butyrate Supports Gut, Cell & Brain Function – Jessica Kane Berman : 982

BodyBio sponsored this podcast. IN THIS EPISODE OF THE HUMAN UPGRADE™… you’ll learn how butyrate and phospholipids keep your gut, cells and brain performing at their best. You’ll find out how your mucosal barrier defends against pathogens in your gut microbiome. You’ll also learn about discoveries in the field of cell membrane medicine. This focus determines how your body functions now and also how you age.Jessica Kane Berman joins the show to share new information and interesting science about cellular health from the perspective of BodyBio, the company founded by her grandfather, Ed Kane, an inventor, health explorer and early biohacker. He went looking for answers to his own health issues in the 1980s and got deep into the science of fatty acid research and cell membrane medicine through blood testing.BodyBio sticks to a very specific group of products, most notably butyrate and a phospholipid complex of phosphatidylcholine. Jess explains how true liposomal phosphatidylcholine and phospholipids get through to the cells to help rebuild that membrane. Here’s a few good things butyrate does in your gut:Helps maintain the thickness of the mucosal barrier—keeps the good in and the bad outHelps the expression of tight junctions and strengthens the gut wallExpresses MUC2: this produces mucus, which thickens your mucous liningRegulates T-Cells and helps lower cytokine releaseIncreases microbiome diversityAnti-inflammatory properties help improve intestinal barrier function and mucosal immunityButyrate goes way beyond the gut to influence bone mass and density, asthma and allergies, histamine intolerance, body detoxification, inflammatory brain pathways, and mitochondrial function. Butyrate also can alter gene expression, protect against cancer, and regulate the body’s immune system.SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: https://bodybio.com/dave, use code DAVE25 to get 25% offWE APPRECIATE OUR PARTNERS. CHECK THEM OUT! Cooler Temps for Deeper Sleep: https://www.chilisleep.com/, use code HUMANUPGRADE20 to save 20% on the Dock Pro Sleep SystemIsometrics for Cardiovascular Health: https://www.zona.com, use code DAVE2022 to get $150 off the Zona PlusShield Yourself from EMFs: https://quantumupgrade.io, use code DAVE to get a two-week free trialSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

29 Sep 202245min

Hacking Brain Fog – Interventions With Dave – Keri Glassman, MS, RD, CDN : 981

Hacking Brain Fog – Interventions With Dave – Keri Glassman, MS, RD, CDN : 981

In this Episode of The Human Upgrade™...​ Dave talks about what could be causing brain fog with a podcast guest in this impromptu intervention. Keri Glassman, MS, RD, CDN, recently spoke about gut health as the expert for Omni-Biotic probiotics. During the interview, she was searching for a word and got frustrated she couldn’t grasp it quickly. This intervention looks at the potential culprits responsible for Keri’s brain fog and memory hiccups: ThyroidHormones, such as testosterone and DHEAPerimenopauseMast cell-mediated inflammationCortisol & stressADHDMold toxinsMercury & leadKeri is a registered dietitian, certified nutritionist, healthy cooking expert and author of four books. She also founded Nutritious Life, a lifestyle and media company and Nutritious Life Studio, an online education platform focused on nutrition, coaching, and business.Find tips and resources on the episode webpage.Note: The "Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.WE APPRECIATE OUR PARTNERS, CHECK THEM OUT!Nature’s Nootropic: https://trukava.com, use code DAVE15 to get 15% offBusiness Growth With SEO: https://www.stephanspencer.com, get a FREE consultationMattress Temperature Tech: https://www.eightsleep.com/dave, use code dave to save $250 on the Pod ProSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Sep 202219min

The Science of Changing Your Mind – Legacy Upgrade ft. Dr. Joe Dispenza : 980

The Science of Changing Your Mind – Legacy Upgrade ft. Dr. Joe Dispenza : 980

IN THIS EPISODE OF THE HUMAN UPGRADE™…a legacy upgrade conversation with Dr. Joe Dispenza explores how you can change from the inside out through a combination of neuroscience, epigenetics, quantum physics—and even a divine source. “I teach people the science of changing their mind and what it is to truly transform,” he says.He shows people how to rewire their brains and recondition their bodies to make lasting changes by way of science, energy and mysticism. His background and expertise include training in neuroscience, neurology, cellular biology, brain function and chemistry, memory formation, and aging and longevity.From healing illness to evolving consciousness, Dr. Dispenza examines how to connect with the divine and bridges the mystical with science. “It's really important to have science demystify that process,” he says. Why? Because science is a contemporary language that offers you explanations, helps you understand the how and why, and assigns clear meaning. “Here's what I know,” Dr. Dispenza says. “We have evidence that you can make your brain work better. As you can prove also, we have evidence that you can make your heart work better. We have evidence, you can strengthen your immune system. We have evidence, you can change your gene expression in four days. We have evidence, you can lengthen your life from meditation, just by lengthening your telomeres and changing your state. We have evidence in the scientific world that people actually can transform.”Listen on to learn about the power of inner work, elevated emotions and human connection.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!A Cleaner Nicotine Alternative: https://lucy.co, use code DAVE20 for 20% off your first order of pouches, gums or lozengesCustomized Nootropics for Your Own Neurochemistry: https://nootopia.com/dave, use code DAVE10 to get 10% off. Learn more on The Human Upgrade podcast: Hack Your Neurochemistry with Customized Nootropics – Mr. Noots & Matt Gallant – #861Probiotic Eases Stress: https://www.omnibioticlife.com/DAVE, use code DAVE20 to get 20% off. Learn more on The Human Upgrade podcast: Upgrade Spotlight: Probiotics to Power the Gut-Brain Axis – Keri Glassman, MS, RD, CDN / Omni-Biotic – #974See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

22 Sep 202259min

Meditation Hacks Get You Into A Peak State in Less Time – Vishen Lakhiani : 979

Meditation Hacks Get You Into A Peak State in Less Time – Vishen Lakhiani : 979

IN THIS EPISODE OF THE HUMAN UPGRADE™… you’ll learn about a “6 Phase Meditation” approach that absolutely everyone can do—and benefit from!—no exceptions. This custom-designed meditation sequence gets you into a peak state in just a few minutes. No boredom, special breathing, or clearing your mind required. You’ll find out how to make meditation work for you and how you can use intuition as one of your greatest strengths.Episode guest Vishen Lakhiani took up meditation at age 26 as a way to cope with the stress of working for a startup in Silicon Valley. That decision changed his life so dramatically that within two years he quit to pursue meditation, other tools of personal development, and then spread awareness and education to people around the world. He’s taught his signature 6-phase meditation style to world-class athletes, professional entertainers and high-performers in all types of business. He also founded Mindvalley, an international learning platform.Vishen’s newest book, “THE 6 PHASE MEDITATION METHOD: The Proven Technique to Supercharge Your Mind, Manifest Your Goals and Make Magic in Minutes a Day,” outlines a series of science-backed mental exercises for accomplishing your goals. It condenses the wisdom of nearly 1,000 neuroscientists, monks, yogis, and meditation experts into a hyper-efficient programming script that you can run through your mind any time of day.Unlike traditional meditation that encourages a calm and serene environment, the 6 Phase Meditation Method can be done from anywhere—your bed, your office or even on your next flight. “It's six different practices that you layer on that put you in a hyper-optimized state,” Vishen says. You’ll get a lot out of this fascinating conversation that gets into realms of spirituality, psilocybin, perceptual diversity, physics, brain waves, and altered states. SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Mindvalley.com/books/6phaseWE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Shield Yourself from EMFs: https://quantumupgrade.io, use code DAVE to get a two-week free trialStructure Water Molecules; Achieve Body/Brain Coherence: https://analemma-water.com, use code DAVE10 for 10% offIsometrics for Cardiovascular Health: https://www.zona.com, use code DAVE2022 to get $150 off the Zona PlusSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Sep 202257min

How to Hack Your Cardio Workout – Ulrich Dempfle : 978

How to Hack Your Cardio Workout – Ulrich Dempfle : 978

CAROL Bike sponsored this podcast. IN THIS EPISODE OF THE HUMAN UPGRADE™ … you’ll learn about new research that’s pinpointing the most effective cardio workouts. You’ll find out that you can do a cardio workout in just 15 minutes a week and still increase your cardiovascular fitness. You’ll also get an introduction to the new CAROL Bike 2.0 and its upgraded great features.Ulrich Dempfle, MBA, Chief Product Officer, CEO and co-founder of CAROL Bike, returns to the podcast with exciting new research results. CAROL’s REHIT (Reduced Exertion HIIT) workout retained all its effectiveness yet cut its time nearly in half—from 8 minutes and 40 seconds to five minutes.CAROL Bike continues to innovate fitness and prove that more or longer sprints aren’t better. “What matters is that you sprint at your personalized maximum intensity, switching from zero to max in a fraction of a second,” Ulrich explains. An investment of only 5 minutes, 3 times a week means you can reap powerful cardiovascular benefits, even gain strength, and get on with your other biohacks.SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://www.carolbike.com. Use code HumanUpgrade to get 2 years of free membership (a total savings of $360). CAROL Bike also offers a 100-day home trial of the CAROL Bike 2.0.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Harness Cold to Improve Health & Performance: https://www.cryobuilt.comSleep Better on Natural Memory Foam: https://myessentia.com, use code DAVEVIP to get an exclusive discount. Learn more on The Human Upgrade podcast: Mattress Smarts 101 for High-Performance Sleep – Jack Dell’Accio – #875Customized Nootropics for Your Own Neurochemistry: https://nootopia.com/dave, use code DAVE10 to get 10% off. Learn more on The Human Upgrade podcast: Hack Your Neurochemistry with Customized Nootropics – Mr. Noots & Matt Gallant – #861See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Sep 202244min

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