Beyond CMV Prevention

In this episode, Raymund Razonable, MD, discusses cytomegalovirus (CMV) management strategies beyond primary prophylaxis in solid organ transplantation recipients including:

  • CMV treatment goals
  • CMV treatment and monitoring recommendations
  • Role of secondary prophylaxis
  • Use of CMV cell–mediated immunity (CMI) monitoring for CMV relapse risk
  • Use of CMV CMI for secondary prophylaxis
  • Proposed use of CMV CMI monitoring for secondary prophylaxis
  • Incidence and outcomes with antiviral resistance
  • Risk factors for CMV resistance
  • When to suspect antiviral resistance
  • Testing for antiviral resistance using genotypic assays
  • Outcomes in patients with ganciclovir-resistant vs ganciclovir-susceptible virus
  • Treatment recommendations for resistant/refractory CMV
  • Efficacy and safety of maribavir vs investigator-assigned therapy for resistant/refractory CMV infections from the phase III SOLTICE study
  • Treatment algorithm for resistant/refractory CMV
  • Adjunctive, investigational, and off-label treatment options for resistant/refractory CMV

Faculty:

Raymund Razonable, MD
Professor of Medicine
Program Director, Infectious Diseases Fellowship
Vice Chair, Division of Infectious Diseases
Mayo Clinic
Rochester, Minnesota

Content based on a CME program supported by an educational grant from Merck & Co., Inc., Rahway, NJ, USA.

Follow along with a downloadable slideset at:
https://bit.ly/476v2wI

Link to full program:
https://bit.ly/47lNK2K


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