Ep 59 Thalidomide: Justice Delayed, Justice Denied

Ep 59 Thalidomide: Justice Delayed, Justice Denied

The story of thalidomide is often employed as a cautionary tale - why testing a drug’s safety during pregnancy is crucial or why it’s important to choose the right animal models. Or it’s framed as a success story for drug repurposing or regulation. But those tellings often gloss over the darker lesson of thalidomide: that for some companies, the bottom line is more important than human life. This week, we explore all elements of this infamous drug. We start by examining what we know about how thalidomide causes the severe congenital malformations it’s associated with, and then we dive into the deep, dark history of the drug, complete with a full cast of villains and heroes. Finally, we discuss thalidomide’s controversial comeback as a treatment for myeloma and complications of leprosy. Get out your angry hats for this one, people, because you’ll find yourself asking along with us, “why are humans the way we are?”

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Episoder(282)

Ep 9 Tuberculosis: A Slow Burn

Ep 9 Tuberculosis: A Slow Burn

Today, we’re taking a page straight out of Dickens and talking about tuberculosis- a disease as rich in history as it is in bloody sputum. We'll travel the path of an individual Mycobacterium tubercul...

2 Jan 201859min

Ep 8 ABRACADABRA - Go Away Malaria!

Ep 8 ABRACADABRA - Go Away Malaria!

It's both a disease of dinosaurs and a plague of people. A gin and tonic might make you forget how much those bites itch, but it won't protect you much from this mosquito-borne monster. That's right p...

19 Des 201759min

Ep 7 Hit Me With Your Best (Polio) Shot

Ep 7 Hit Me With Your Best (Polio) Shot

A scientific rivalry for the ages, a president with a closely kept secret, and a summertime with no pool time. What do all these things have in common? Well step right up and take a listen- today we'r...

12 Des 20171h 1min

Ep 6 Plague Part 2: TGFA

Ep 6 Plague Part 2: TGFA

We're back with another episode all about plague-TGFA: Thank Goodness For Antibiotics! Today we'll focus on the status of plague in the modern world: where it is, where it isn't, and what we can do ab...

5 Des 201740min

Ep 5 Plague Part 1: The GMOAT

Ep 5 Plague Part 1: The GMOAT

That's right y'all... Today we're talking the GMOAT: The GREATEST MORTALITY OF ALL TIME: BLACK DEATH. This episode we'll cover the biology and history of one of the most epic diseases of all time- Yer...

28 Nov 201759min

Ep 4 The Poop Show

Ep 4 The Poop Show

That's right.. this is the poop show! Today we talk cholera- the bacterial disease that makes you liquid-poop your pants (and then some). Travel back in time with us to when London was a sewage-filled...

21 Nov 201749min

Ep 3 Gnarlypox

Ep 3 Gnarlypox

This week we pay tribute to one of the gnarliest diseases of all time, and the only human disease that's ever been eradicated (thus far). That's right, people- we're talking smallpox! It's gonna get g...

14 Nov 201757min

Ep 2 Skin in the Game, Horse in the Race

Ep 2 Skin in the Game, Horse in the Race

This week we tackle leprosy. That biblical (or is it?) infection that, believe it or not, is still with us today. Leprosy has an ancient history that exemplifies some of the worst of human behavior, a...

7 Nov 201754min

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