Essentials: Understanding & Conquering Depression
Huberman Lab3 Jul 2025

Essentials: Understanding & Conquering Depression

In this Huberman Lab Essentials episode, I explore major depression, including its underlying biology and discuss science-based approaches to alleviate symptoms and improve mood. I describe the wide-ranging symptoms of depression and explain how key neurotransmitters, hormones, stress, genetics and inflammation contribute to its development and persistence. I also cover treatment options, from traditional classes of antidepressant medications to emerging therapies such as ketamine and psilocybin. Finally, I highlight lifestyle-based tools, including exercise, supplementation and dietary strategies that can help manage depressive symptoms and promote mental well-being. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Our Place: https://fromourplace.com/huberman Timestamps 00:00:00 Major Depression 00:01:10 Depression Symptoms 00:06:14 Sponsor: BetterHelp 00:07:33 Pharmaceuticals for Depression, SSRIs; Norepinephrine, Dopamine & Serotonin 00:14:33 Thyroid Hormone, Cortisol, Stress & Depression, Menstrual Cycle, Genetics 00:17:43 Sponsor: AG1 00:19:20 Increase Norepinephrine, Tools: Deliberate Cold Exposure & Exercise 00:21:40 Chronic Inflammation & Depression, Tools: Omega-3s (EPA) & Exercise 00:26:49 Sponsor: Our Place 00:28:41 Tool: Creatine Monohydrate Supplementation & Improving Depression 00:30:20 Novel Depression Therapies, Ketamine, Psilocybin 00:35:29 Ketogenic Diet & Refractory Depression, GABA 00:37:57 Recap & Key Takeaways Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Episoder(376)

Essentials: Using Play to Rewire & Improve Your Brain

Essentials: Using Play to Rewire & Improve Your Brain

In this Huberman Lab Essentials episode, I discuss why play is a powerful yet often overlooked tool for shaping the brain across the entire lifespan, not just during childhood. I explain how play enga...

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Science & Tools of Learning & Memory | Dr. David Eagleman

Science & Tools of Learning & Memory | Dr. David Eagleman

Dr. David Eagleman, PhD, is a neuroscientist, bestselling author and professor at Stanford University. We discuss how to leverage the science of neuroplasticity to learn new skills and information and...

26 Jan 2h 24min

Essentials: Therapy, Treating Trauma & Other Life Challenges | Dr. Paul Conti

Essentials: Therapy, Treating Trauma & Other Life Challenges | Dr. Paul Conti

In this Huberman Lab Essentials episode, my guest is Dr. Paul Conti, MD, a psychiatrist and expert in treating trauma and psychiatric illness. We explain what trauma is and how it affects the mind a...

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Build Muscle & Strength & Forge Your Life Path | Dorian Yates

Build Muscle & Strength & Forge Your Life Path | Dorian Yates

Dorian Yates is a former professional bodybuilder, six-time Mr. Olympia winner and a pioneer of high-intensity, low-volume training for building muscle size and strength. He explains how anyone can va...

19 Jan 2h 47min

Essentials: Tools to Boost Attention & Memory | Dr. Wendy Suzuki

Essentials: Tools to Boost Attention & Memory | Dr. Wendy Suzuki

In this Huberman Lab Essentials episode, my guest is Dr. Wendy Suzuki, PhD, a professor of neural science and psychology at New York University. We discuss simple, daily habits to improve focus, memo...

15 Jan 40min

How to Overcome Addiction to Substances or Behaviors | Dr. Keith Humphreys

How to Overcome Addiction to Substances or Behaviors | Dr. Keith Humphreys

Dr. Keith Humphreys is a professor of psychiatry and behavioral sciences at Stanford School of Medicine and a leading expert on treating addictions, drug laws and policy. We discuss all the major addi...

12 Jan 3h 27min

Essentials: Optimizing Workspace for Productivity, Focus & Creativity

Essentials: Optimizing Workspace for Productivity, Focus & Creativity

In this Huberman Lab Essentials episode, I discuss how to optimize your workspace to maximize productivity, focus and creativity. I explain how key environmental factors such as lighting, the physica...

8 Jan 34min

Best Ways to Build Better Habits & Break Bad Ones | James Clear

Best Ways to Build Better Habits & Break Bad Ones | James Clear

James Clear is an expert on behavioral change and habits and the author of the bestselling book Atomic Habits. We discuss the best ways to build new healthy habits and end bad ones without relying on ...

5 Jan 2h 35min

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