Perimenopause Simplified21 Aug 2025

76. Feeling Sad, Irritable, or Unmotivated Over 40? Here's What's Really Going On

In this episode, Claudia gets vulnerable, sharing her own struggle with depression, the steps she took to overcome it, and how you can navigate depression in perimenopause.

In this episode we covered:

How hormone changes in perimenopause affect mental health
How nutrient imbalances and gut health play a role in depression
The life transitions perimenopause women experience
Frustrations with your body and health in perimenopause
The impact of unaddressed trauma
Is it time to slow down or consider a career change?
Steps to overcome depression including supplement suggestions

WATCH ON YOUTUBE.

Links Mentioned:

Episode 18: The Perimenopause Diet I Recommend

Episode 10: Why You Can't Sleep in Peri

Episode 24: Rethinking Sleep in Perimenopause W/ Morgan Adams (Sleep Coach)

Necklace

Cure Hydration (use code: healthcoachclaudia to save 20%)

Seeking Health

Sources:

https://www.mountsinai.org/health-library/supplement/5-hydroxytryptophan-5-htp

https://pmc.ncbi.nlm.nih.gov/articles/PMC5020390/

https://pmc.ncbi.nlm.nih.gov/articles/PMC4393508/

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/485215

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Learn more here.

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CONNECT WITH CLAUDIA:

FREE RESOURCES:

Peri-What?! The Must-Have Guide for Women 40+ Navigating Hormone Changes

Perimenopause Daily Checklist

HRT 3-Day Crash Course

GET SUPPORT:

Perimenopause Clarity Session

The Perimenopause Method Program

Perimenopause HRT Roadmap Course

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Episoder(131)

130. How to Manage Anxiety in Perimenopause with Dr. Anne Hussain

👉🏼FREE RESOURCES: 6 Reasons You're Experiencing Brain Fog, Anxiety & Mood Changes After 40 - https://claudiapetrilli.myflodesk.com/6-things-labs In today's special episode, Claudia was featured in...

11 Nov 29min

129. Brain Fog & Overwhelm Over 40: How to Get Clear & Calm

Brain fog, forgetfulness, irrational thoughts, and focus issues are common in perimenopause - but rarely explained. In this episode, we explore what's really happening to the female brain during the p...

28 Okt 11min

128. Breast Health After 40: What to Know About Hormones, Iodine & Lifestyle

Breast health deserves more attention than a yearly mammogram. In this episode, Claudia is joined by Dianne Wist, Breast Health Educator and CEO of Violet Daily, for a conversation about what women ov...

21 Okt 49min

127. Perimenopause Rage: Why It Happens & What to Do About It

Have you been feeling unusually irritable, moody, or downright angry in the days leading up to your period? Perimenopause rage can feel overwhelming, especially when you don't understand why your emot...

14 Okt 17min

126. Mood Swings & Anxiety: Could Estrogen Be The Missing Piece?

Estrogen often gets a bad rap, but it's one of the most powerful and protective hormones in a woman's body, especially in midlife. In this episode of Perimenopause Simplified, we're unpacking what est...

7 Okt 17min

125. Your OBGYN Probably Can't Help You in Perimenopause

In this week's episode, Claudia addresses one of the BIGGEST frustrations women face–going to their OB/GYN for perimenopause help, only to realize they're not as knowledgeable about hormones as we exp...

30 Sep 10min

124. Gaining Weight on HRT? Here's How to Fix It

Many women start hormone therapy expecting relief from hot flashes, brain fog, and mood swings - only to be frustrated when the scale starts creeping up. While providers often dismiss it, weight gain ...

23 Sep 13min

123. Why HRT Isn't Enough to Fix Your Perimenopause Symptoms

If you've started hormone replacement therapy (HRT) but still feel exhausted, anxious, bloated, moody or worse – you're not alone. In this episode, I'm breaking down why hormone therapy alone isn't en...

16 Sep 10min