10-Minute Weekly Update : 1339

Upgrade your week in just 10 minutes with D(AI)ve Asprey’s essential rundown on what matters most in longevity, biohacking, AI health tech, and medical freedom.


This episode covers:


Apple Cider Vinegar Myth Busted

A weight-loss study just got retracted. ACV will not melt fat, but it may blunt glucose spikes or ease digestion when diluted in water before carb-heavy meals. Skip the shots and protect your teeth.

Source: https://www.sciencedaily.com/releases/2025/10/251001092216.htm


NMN Is Back

The FDA reversal puts NMN back on shelves as a clean NAD precursor. Dave explains why quality, cycling, and stacking with anti-inflammatory strategies make the difference.

Source: https://www.prnewswire.com/news-releases/renue-by-science-celebrates-fda-reversal-confirming-nmn-is-lawful-for-use-in-dietary-supplements-302573317.html


Poor Sleep Ages Your Brain

Machine learning MRI studies show poor sleep makes your brain biologically older and raises dementia risk. Dave shares the three dials to track (deep sleep, REM, resting heart rate) and the three biggest levers to fix them.

Source: https://www.sciencedaily.com/releases/2024/10/241023171543.htm


Psilocybin for Lasting Reset

New research finds a single guided dose can unlock plasticity, ease pain patterns, and lift mood for weeks. Dave outlines safe protocols, integration steps, and why it is a strategic reset tool, not a party trick.

Source: https://www.sciencedaily.com/releases/2025/06/250616040215.htm


AI Detects Cancer Earlier

A new AI tool called DOLPHIN can find hidden genetic markers to flag cancer risk sooner. Pairing high tech scans with low tech terrain fixes like sleep, muscle, and insulin control is the prevention model that works.

Source: https://www.sciencedaily.com/releases/2025/10/251001092206.htm


All source links provided for easy reference to the original reporting and research above.


This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: Apple cider vinegar, weight loss myths, NMN supplements, NAD precursors, cellular energy, sleep and dementia, brain aging, deep sleep optimization, REM sleep, psilocybin therapy, BDNF, neuroplasticity, pain relief, mood reset, AI cancer detection, early cancer screening, biohacking news, longevity science, Dave Asprey, Human Upgrade podcast


Thank you to our sponsors!


Resources:

• Danger Coffee: https://dangercoffee.com/discount/dave15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com


Timestamps:

0:00 — Introduction

0:18 — Story 1: Apple Cider Vinegar and Weight Loss

1:49 — Story 2: NMN is Back in Supplements

3:31 — Story 3: Sleep and Brain Health

5:39 — Story 4: Psilocybin and Lasting Relief

7:49 — Story 5: AI Tool DOLPHIN for Early Cancer Signals

9:48 — Conclusion & Weekly Roundup

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Episoder(1417)

#49 Q & A Eggs, Butter & Zen - Podcast

#49 Q & A Eggs, Butter & Zen - Podcast

About once a month, I set aside a whole podcast to answer questions from the Bulletproof community. It's all about answering your very best questions, sourced from e-mail, Facebook, Twitter, the Bulletproof forum and the blog! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Jul 201359min

#48 “Fat Burning Man,” Abel James and Bulletproof Exec Unite

#48 “Fat Burning Man,” Abel James and Bulletproof Exec Unite

This podcast is with Abel James – a #1 best-selling author, fat loss coach, musician, radio show host, and veritable health crusader. Abel also runs the extremely popular “Fat Burning Man” show – which is one of the top health podcasts on iTunes.  A former strategic advisor to the food and beverage industry, Abel now acts as a consumer advocate who exposes the truth behind deceptive marketing practices, misleading corporate propaganda, and powerful special interests that have accelerated the worldwide obesity epidemic and health crisis. Abel harnesses the techniques he developed for the Lean Body System to achieve extremely compelling results in fat loss and health for his clients and the community. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Jul 201356min

#47 Biohacking Cows, Bulletproof Dairy and Probiotics with Natural Health Expert, Jordan Rubin

#47 Biohacking Cows, Bulletproof Dairy and Probiotics with Natural Health Expert, Jordan Rubin

Jordan Rubin is one of America’s most recognized and respected natural health experts. He is the author of the New York Times best selling book, The Maker’s Diet, as well as the author of 19 other health related titles, including his latest work Perfect Weight America. An international motivational speaker, Jordan hosts the weekly television show Extraordinary Health that reaches more than 30 million households worldwide. He is Founder and CEO of Garden of Life, a leading health and wellness company committed to empowering extraordinary health with whole food based supplements, functional foods, and founder of Beyond Organic. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Jun 201349min

#46: Reichart Von Wolfsheild - Bulletproof Your Systems

#46: Reichart Von Wolfsheild - Bulletproof Your Systems

Reichart Von Wolfsheild, is a co-host on History Channel’s Invention USA.  He is a technologist, inventor, artist and futurist. Starting in his teens, he designed and built a computer CPU from scratch. In the early 1980s, while helping pioneer music videos for the then-fledgling network, MTV, he started his first successful technology company developing Artificial Intelligence applications. Blending his talents from several fields he made history conceiving one of the first multi-player modem video games, kicking off a franchise. He has designed everything from toys to weapons and developed more than 120 products for companies such as Boeing, Disney, Dreamworks and Mattel, and is always looking for the next fun challenge. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Jun 201346min

#45: Q & A More on Coffee, Kale, & Adrenal Fatigue

#45: Q & A More on Coffee, Kale, & Adrenal Fatigue

Questions Asked in the Podcast:   1:20 What is the best way to store Bulletproof Coffee and can you pre-grind it and store it? 4:10 For people who like to do heavy workouts several times a week what do you recommend for  recovery and muscle building? 5:30 What's the deal with drugs, specifically marijuana? Is it Bulletproof? 7:14 What about marijuana by products like Hemp protein powder or Hemp seed oil? 8:44 How can I get a Bulletproof T-shirt like the one Dave had on the Joe Rogan Experience? (bulletproofexec.com/shirts) 10:01 What are the differences between the new Bulletproof Upgraded Brain Octane Oil and the Bulletproof MCT Oil? Does the Octane Oil replace the MCT Oil or is it mean to be an addition? 13:10 Can I add the Upgraded Whey into my coffee without pushing myself out of ketogenesis? 14:28 Why is there no Certified Organic label on the MCT Oil? 15:10 How do you make a proper iced ,and blended iced, Bulletproof coffee without the fat sticking to the sides or globbing together? 16:22 Is taking Bioidentical growth hormone safe? 17:34 In the Kale Shake you list raw eggs as a potential addition, would eggshells work as well? 18:49 I massage my kale before blending or sauteing it, do I still need to stew this before steaming, or should I just cut the massage out altogether? Also are the oxalates in baby kale less? 19:43 Should I make a kale shake in addition to or in lieu of Bulletproof coffee? 20:35 Are kale chips Bulletproof? 22:19 Why is Bulletproof Coffee NOT affected by the coffee fungus problem? 24:21 Changing your diet making you stinky? 26:40 Activated charcoal and its benefits 30:24 How do I recover if I have a cheat meal from the Bulletproof Diet? 32:03 How to schedule Bulletproof Coffee and Diet around a crazy sleep schedule 35:30 Can I substitute kale with broccoli to avoid the toxins? 35:50 Adrenal Fatigue, how do you know you have it, what are some common causes, and how do I make it better? 39:35 How do you gain weight while Bulletproof? 42:35 Biohacks of the week and other conversation...   See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Jun 201349min

Bonus: Client Review with Jonathan Kos

Bonus: Client Review with Jonathan Kos

Jonathan Kos is an IT professional and a recent follower of the Bulletproof Diet.  He is a 44 year old IT professional . At 6' 3" and a former college athlete that played football, competitive ice hockey up until the age of 25 he was an extremely fit 220 lbs and my coaches wanted me up to 275 or so to play the defensive line so I was eating literally non stop to put weight on. After college he dropped down to around 200 lbs and eventually settled at for me was a healthy 235.  As he got older and more settled in his job, his weight climbed and he couldn’t keep his weight in check with exercise alone and he started to have to diet he was up to 300 lbs and was exercising more that ever but the weight didn’t come off. After he met his wife, exercise was out the window, a carb heavy diet was in, and his weight ballooned up to 365lbs. He was about to give up until he heard Tait Fletcher on Joe Rogan's podcast mentioning Bulletproof ® Coffee and he gave it a shot. He lost 45lbs in 45 days, and is here to share his experience with you.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Jun 201311min

#44: Salt and self-experimentation with Greg Pomerantz

#44: Salt and self-experimentation with Greg Pomerantz

For Greg Pomerantz everything is a science experiment. He takes citizen science to a personal level by biohacking his blood pressure and detailing his data. He blogged about his self-experiment research on salt clarifying some concerns he had about salt’s effect on the body. He determined what his salt type is, either one is salt sensitive, or one that isn’t affected much by increases in salt. He discusses how to do that in today’s podcast. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Jun 201337min

#43: Kelly Starrett, Mobility and Performance

#43: Kelly Starrett, Mobility and Performance

Coach Kelly Starrett received his Doctor of Physical Therapy in 2007 from Samuel Merritt College in Oakland, California. He currently runs his own physical therapy practice at San Francisco CrossFit—one of the first 50 CrossFit affiliates—and focuses on performance-based Orthopedic Sports Medicine with an emphasis on returning athletes to elite level sport and performance. His clients see exceptional results from his progressive blend of manual physical therapy and strength training. Since 2009, Kelly has been traveling the country teaching his "Movement, Mobility & Maintenance Course" in an effort to spread his message that good mobility and proper movement are the keys to good performance and that all humans should be able to perform this basic maintenance on themselves. Kelly's clients have included Olympic gold-medalists, Tour de France cyclists, world-class extreme skiers and X-Games medalists, dancers with Smuin, San Francisco, and Sacramento Ballet Companies, military personnel, and competitive age-division athletes. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Mai 201350min

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