The Methylene Blue Episode | Solo Biohacking Masterclass  : 1366

The Methylene Blue Episode | Solo Biohacking Masterclass : 1366

Methylene blue is one of the most misunderstood compounds in biohacking, yet it can upgrade your energy, mood, memory, and cellular resilience when you use it the right way. We are back again with another solo masterclass, and this one breaks down how to use methylene blue as a precision tool for brain optimization, longevity, and human performance while avoiding the dosing mistakes that create jitteriness, sleep disruption, or dangerous interactions.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


Host Dave Asprey guides you through more than a century of research on methylene blue. He has been hacking this compound since the early 2000s and brings deep insight into mitochondria, neuroplasticity, metabolism, supplements, fasting, red light, ketosis, nootropics, and functional medicine. You will learn how methylene blue works inside the cell, how it improves electron transport, and why it appears in neurology, psychiatry, and anti aging research at the same time. This episode shows you how to test your own dose, how to stack it with light and ketosis for maximum effect, and how to avoid serotonin syndrome or sleep disruption.


Methylene blue also touches nearly every major system that biohackers care about, which is why this solo masterclass shows you how it interacts with mitochondria, neuroplasticity, metabolism, sleep optimization, and long term anti aging pathways. You will hear how it influences redox balance, ATP production, brain optimization, and stress resilience, and how it behaves when combined with ketosis, fasting, creatine, NAD boosters, red light therapy, or other nootropics. Host Dave Asprey explains why methylene blue pairs well with certain supplements but clashes with psychedelics or SSRI medications, how it fits into functional medicine protocols for mitochondrial repair, and how to use data and wearable tracking to dial in your response. This episode gives you a complete framework to evaluate whether methylene blue belongs in your personal longevity strategy and how to use it with precision instead of guesswork.


You’ll Learn:

• Why methylene blue acts like mitochondrial jumper cables and when it improves energy and mood

• The exact signs that your dose is too strong, too weak, or in the Goldilocks zone

• How methylene blue interacts with neuroplasticity, memory circuits, and cognitive resilience

• Why psychedelics, SSRIs, and MAO inhibitors can create dangerous serotonin interactions

• How to pair methylene blue with red light therapy, ketosis, creatine, fasting, or NAD boosters

• The link between mitochondrial health, fertility, libido, and long term anti aging strategies

• How to track sleep optimization, HRV, and performance signals to dial in your personal protocol

• The difference between aquarium grade dye and pharmaceutical grade formulations

• Why genetic testing for G6PD deficiency is essential before higher dose experimentation


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: methylene blue dosing, mitochondrial electron transport, Complex IV cytochrome c oxidase, redox cycling, MAO inhibition, serotonin syndrome risk, G6PD deficiency caution, neuroplasticity enhancement, dendritic spine density, mitochondrial stress adaptation, red light therapy stacking, cognitive performance optimization, ketone supported ATP production, nitric oxide independent focus boost, mitochondrial bottleneck repair, pharmaceutical grade methylene blue, sleep disruption signals, biohacking fertility support, oxidative stress buffering, functional medicine mitochondria repair


Thank you to our sponsors!

-BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.

-fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.

-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.


Resources:

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com


Timestamps:

0:00 — Trailer

1:25 — Introduction

4:51 — History of methylene blue

7:38 — How methylene blue works

14:05 — Safety

17:53 — Dosing and timing guidelines

20:41 — Combining with red light therapy

22:41 — Quality and sourcing

23:17 — Dosing protocols

25:24 — Longevity and fertility effects

29:24 — Stacking options

32:10 — Common questions and FAQs

33:40 — Future research and wrap up

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Episoder(1425)

What You’re Getting Wrong About Exercise – Sal Di Stefano : 1134

What You’re Getting Wrong About Exercise – Sal Di Stefano : 1134

I’m pumped to welcome one of the hosts of the Mind Pump Podcast, top trainer and entrepreneur Sal Di Stefano. Mind Pump pulls back the curtain on the health, fitness, and nutrition industries, cuts through the pseudo-science, and offers science-backed solutions for enhancing performance while emphasizing health. Sal started his journey in the gym at age 14, and I admire how he’s steadily grown a meaningful business around biohacking fitness. On today’s episode, we take on some weighty topics like weight training vs. cardio, why veganism is dangerous, and why reverse dieting may actually be the key for results. Sal explains his fitness philosophy, which focuses on functional movement, reframing your mindset around exercise, and consistency above all else. We also get into the nutrition side of things. Sal and I break down how much protein you should be eating per day, plus our favorite proteins—and the evil ones we avoid. We also talk carbs. Do they make you fat? How do they impact performance? What are the best sources? Then, we get fired up talking about how you can fire up your metabolism. This episode is for everyone, from gym newbies to serious bodybuilders. And check out my episode on The Mind Pump Podcast to get a double dose of me and Sal (watch or listen).(00:01:03) Are Bodybuilders the Edgiest Biohackers?(00:04:51) Strength Training vs. Cardio(00:12:27) Strength Training as a Longevity Tool(00:16:32) Moving Toward Functional Movement(00:21:10) Reframing Movement in Your Mind(00:29:17) Why Veganism Is Dangerous(00:33:27) Do Carbs Make You Fat?(00:38:34) Should You Reverse Diet?(00:40:54) How Much Protein Should You Eat?(00:50:18) Is There Any Good Reason To Eat Chicken?(00:55:10) Winning Carb Choices(00:59:42) Sal’s #1 Recommended Supplement(01:02:00) The Single Biggest Fitness MistakeSponsorsMitosynergy | Get 15% off now at Mitosynergy.com/Dave40 Years of Zen | Upgrade Your Brain in 5 Days by going to 40YearsOfZen.com/DaveResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Mind Pump Podcast: mindpumppodcast.comMind Pump Training Protocols: mindpumpmedia.com/maps-fitness-productsMind Pump Instagram: @mindpumpmediaSal’s Instagram: @mindpumpdistefanoX: @mindpumpsalTikTok: @mindpumpmediaYouTube: @MindPumpShowThe Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Feb 20241h 5min

The Art of Deep Rest: Yoga Nidra Breathwork  – Tracee Stanley : 1133

The Art of Deep Rest: Yoga Nidra Breathwork – Tracee Stanley : 1133

Dive into yoga nidra with Tracee Stanley, a renowned teacher and author who unveils the transformative power of rest. Her book, "Radiant Rest," showcases the vital role of recovery in biohacking, advocating for the strength found in stillness. Tracee, with over twenty years of experience and collaborations with icons like Marianne Williamson, is a leader in the realm of deep rest and clarity. Her latest work, "The Luminous Self," deepens this exploration, aligning with our aim to unlock inner power for a fulfilling life. Today, we delve into yoga nidra's science, its profound effects on our brain, and how it connects us to our roots, reshapes habits, and promotes deep healing. Tracee's approach not only offers a pathway to better understanding and caring for ourselves but also redefines our relationship with rest and the world. Her insights are essential for anyone seeking a holistic biohack for body and mind wellness, providing clarity, compassion, and the gift of deep rest.(00:00:40) Accessing Real Rest & Peace With Yoga Nidra(00:12:25) One Free Daily Practice for Better Sleep, Focus & Productivity(00:26:34) Exploring Death Practices & Connecting to Nature(00:42:34) Creating a Legacy of Peace: Passing on Indigenous Traditions & Teachings(00:53:50) Healing a Sleep Deprived World & Confronting the Root Cause of Suffering(01:08:13) Exploring Tracee’s Tools for Connection & HealingSponsorsCalroy | Calroy.com/Dave for an exclusive discountBioptimizers Blood Sugar Breakthrough | Go to BloodSugarBreakthrough.health/Dave and use code “Dave10” for 10% off your order.ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Read: The Luminous Self by Tracee StanleyRead: Radiant Rest by Tracee StanleyWebsite: traceestanley.comInstagram: @tracee_stanleyThe Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Feb 20241h 19min

Save Face: Non-Surgical Solutions From a Plastic Surgeon – Dr. Rob Whitfield : 1132

Save Face: Non-Surgical Solutions From a Plastic Surgeon – Dr. Rob Whitfield : 1132

Today’s show is a masterclass in improving your skin without going under the knife. I’m excited to welcome back Dr. Rob Whitfield, an Austin-based plastic surgeon who specializes in breast implant removal surgeries and advanced cosmetic procedures. He invented the famous “No-Cut” Facelift, which revolutionized non-surgical facelifts for a more natural appearance. I worked with Rob on a “No-Cut” Facelift, and he removed excess skin from my back after my weight loss. I got to be the guinea pig, and now I’m sharing everything I learned with you. On today's episode, I recount my experience and results with these procedures. Dr. Rob explains what a “No-Cut” Facelift is, plus other non-surgical procedures to tighten fat, remove excess skin, and reduce wrinkles. We talk about radio frequency-assisted lipolysis, SoftWave therapy, Morpheus8, and a whole lot more. Plus, we get into foods that hurt your skin, injectable vs. topical peptides, and biohacking skincare. Basically, it’s everything you need to know for younger, healthier-looking skin. And let’s face it, we all want that. (00:01:58) Dave’s Experience Working With Dr. Rob(00:08:48) What Is a “No-Cut” Facelift?(00:19:10) Shrinking Fat With Radio Frequency Assisted Lipolysis(00:22:13) Zoom Lifts & More Non-Surgical Procedures(00:29:02) What Is SoftWave Therapy?(00:33:28) Biohacking for Skincare(00:34:47) Morpheus8: Good or Bad?(00:35:53) Treatments for Excess Skin(00:37:44) How Bad Are BBLs?(00:41:57) Does Your Skin Have a Biological Clock?(00:45:32) Foods That Hurt Your Skin(00:48:18) Topical vs. Injectable Peptides(00:50:17) The Bright Side of Sun Exposure(00:53:42) What To Do for Your Skin at 25SponsorsLeela Q | Visit LeelaQ.com/Dave for 10% off.Timeline Nutrition | Go to TimelineNutrition.com/Dave and get 10% off your order.ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: drrobertwhitfield.comThe HARP™️ Method: harp.healthInstagram: @breastimplantillnessexpertInstagram: @drrobwhitfieldFacebook: Dr. Rob Whitfield MDYouTube: @breastimplantillnessexpertTikTok: @drrobertwhitfieldHow Breast Implants Compromise Your Health and Make You Sick #1043The Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

8 Feb 202459min

Insidious Inflammation & How To Fight It – Maggie Berghoff : 1131

Insidious Inflammation & How To Fight It – Maggie Berghoff : 1131

Inflammation is at the root of everything. More inflammation means less energy and a higher risk of every disease. Today, we’re digging into exactly why inflammation is so insidious with functional medicine nurse practitioner Maggie Berghoff. Maggie is a USA Today National Best-Selling author of the book Eat to Treat: Your Three-Step Plan To Reduce Inflammation, Detoxify Your Life, And Heal Your Body. She is also the founder of wellness supplement and non-toxic home line DETOXDaily. In this episode, we talk all about inflammation—what causes it, how it hurts us, and how to combat it. We explore all the different types of inflammation, including physiological vs. psychological inflammation– and dig into how inflammation intersects with hormone health, thyroid function, and metabolic syndrome. Maggie also shares her perspective about shedding shame around eating, and why perfectionism can be even more toxic than actually toxic foods. Plus, I share a lot of horrifying (but medically useful) information about urine. You’ll be equally intrigued and grossed out. (00:01:29) The Ills of Inflammation(00:07:23) Physiological vs. Psychological Inflammation(00:15:00) 3 Things That Cause Inflammation(00:25:26) Are We More Inflamed Now Than Ever?(00:27:19) Where Do You Start Combating Inflammation?(00:30:09) What Is Your Inflammation Type?(00:35:50) When Your Hormones Are in Havoc(00:46:58) Metabolic Syndrome’s Role in Inflammation(00:49:22) The Nightmare of Poor Sleep(00:55:18) Shedding Shame Around Food(01:02:20) Why Not Just Take Aspirin?SponsorsQuantum Upgrade | Go to QuantumUpgrade.io/dave for a 15 day free trialStemregen | Go to Stemregen.co/dave for 20% offResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: maggieberghoff.comEat To Treat: eattotreat.comDETOX Daily: yourdetoxdaily.comInstagram: @maggie_berghoffFacebook: Maggie Berghoff TikTok: @maggie_berghoff Linkedin: Maggie Berghoff The Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Feb 20241h 11min

Change Your Morning, Change Your Life – Hal Elrod : 1130

Change Your Morning, Change Your Life – Hal Elrod : 1130

Meet a man who makes miracles happen. Today, I’m joined in the studio by Hal Elrod, author of the international bestseller The Miracle Morning and his newest book, The Miracle Equation. After overcoming multiple near-death experiences and financial hardships, Hal channeled his adversity into helping others overcome their own challenges. His Miracle Morning approach has impacted millions of lives.On today’s episode, Hal tells us all about his updated version of The Miracle Morning. He explains SAVERS, the six foundational practices that will transform your morning and change your life. We also talk about tips for hacking your sleep, productivity, and relationships. Hal shares the stories of his devastating car accident and rare cancer diagnosis—and the superpowers he gained from coming back to life. We explore how these near-death experiences changed his perspective on life and what he values most. He also tackles some tough questions… Should we try to help everyone? What does it mean to be a “man”? And what does it take to truly serve others? There’s so much to take away from Hal’s refreshing and optimistic perspective. (00:03:20) Creative Ways To Hold Yourself Accountable(00:13:57) Ditching Veganism(00:21:08) Hal’s Near-Death Experiences(00:27:35) Taking Your Health in Your Hands(00:29:37) Did Hal Come Back With Superpowers?(00:31:55) Are You Supposed To Help Everyone?(00:40:51) How the Miracle Morning Changed Hal’s LIfe(00:43:42) What Does It Mean To Be a “Man”?(00:51:25) Customizing Your Morning To Meet Your Needs(00:54:05) The Six Savers for Success(00:56:53) Tips To Save Your Sleep(01:01:51) The MVP of Personal Development Practices(01:06:14) Nourishing Our ConnectionsSponsorsViome | Go to Viome.com/Dave and save $110 on the full-body intelligence test. Neurohacker | Go to Neurohacker.com/Dave and try it risk free for up to 100 days. Use code “DAVE” at checkout for 15% now.ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Read: The Miracle Morning and The Miracle EquationWebsite: halelrod.comFacebook: Hal ElrodX: @HalElrodYouTube: @HalElrodThe Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Feb 20241h 13min

The New Fountain of Youth: Plant-Based Stem Cells - Christian Drapeau : 1129

The New Fountain of Youth: Plant-Based Stem Cells - Christian Drapeau : 1129

Imagine the benefits of stem cell regeneration without needles or a high cost. Today, I'm excited to introduce Christian Drapeau, inventor of a groundbreaking plant-based stem cell product for health and longevity.Christian is more than a scientist; he's a stem cell expert and herbalist, pioneering plant-based stem cell enhancers. Yes, plants and stem cells together! His background from McGill University and work at Stemtech International make him a leading voice in stem cell science. His book, 'Cracking the Stem Cell Code,' reveals how our bodies use stem cells for repair, and his latest research shows how aquatic plants can boost stem cell production, like nature's own fountain of youth.We'll explore how Christian's journey in ancient herbalism led to innovative discoveries in stem cell enhancement and clarify the difference between traditional procedures and products like STEMREGEN. Stay tuned for key answers: How do stem cells promote longer, healthier lives? What's the truth about stem cells and cancer? When's the best time to start using these products?I'll also share my personal routine for maximizing stem cell supplement effects. If you're excited about affordable, effective health benefits, try STEMREGEN. Visit stemregen.co/dave to save 20% on your order.(00:01:09) STEMREGEN: Understanding The Herbalism x Stem Cell Crossover(00:12:21) Stem Cells & Longevity 101(00:23:55) The Historical Context of Healing & Longevity with Plants(00:32:05) Affordability & Cancer Prevention with STEMREGEN(00:44:27) Preventing Kidney Stones & Lowering Your pH (00:57:37) Dave’s Biohacking Stack for STEMREGEN Enhancement (01:05:51) Improving Mitochondrial Function & Measuring AgeSponsorsBioptimizers | Go to Bioptimizers.com/dave, and use code "Dave10" for 10% offResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: stemregen.co/daveInstagram: @stemregenYouTube: STEMREGENThe Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

30 Jan 20241h 15min

The Superfoods That Are Killing You – Teri Cochrane : 1128

The Superfoods That Are Killing You – Teri Cochrane : 1128

Today, we’re digging into specifics about food that you haven’t heard on the show before. This one may very well influence you to rethink your “healthy” diet and change how you feel about food completely. To get there, I’m excited to welcome back Teri Cochrane, an integrative practitioner and pioneer in personalized healthcare. Teri is the founder of the Global Sustainable Health Institute® and developer of The Cochrane Method®, a future-facing algorithm for decoding the human body. Teri is also one of the world’s leading experts on dietary amyloids, which is a topic I love talking about.In today’s episode, we get into what amyloids are and how they turn on viruses, cause cancer, and shorten our lives. We also explore the dangers of oxalates and histamines, plus hacks to reduce and release them. Teri and I both have our own recipes for releasing oxalates that you can try at home (they’re surprisingly simple). We talk about how dirty poultry is killing us—and how superfoods like kale and almonds aren’t any better. We break down the benefits of regenerative farming, and share ways to make your dollar stretch if you can’t afford grass-fed meat. Plus, Teri tells us what she personally eats. (00:02:01) The Big 4 Metabolic Impairments(00:08:21) The Dangers of Oxalates(00:12:02) The Fifth Disruptor: Histamine(00:16:22) Becoming Your Own Body Interpreter(00:28:41) How Do We Get Off Oxalates?(00:35:41) Dave’s Recipe for Releasing Oxalates(00:44:40) Hacks for Histamines(00:50:32) Amyloid 101: What You Should Know(00:56:56) Should You Beware of B6?(00:59:54) What’s the Best Kind of Protein?SponsorsCalroy Arterosil & Vascanox Bundle | Head over to calroy.com/dave for an exclusive discount.ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: tericochrane.comInstagram: @tericochranebeyondnutritionYouTube: @TeriCochraneThe Global Sustainable Health Institute: globalsustainablehealthinstitute.comRead: The Wildatarian Diet by Teri Cochrane What You Eat is Turning Your Genes On and Off – Teri Cochrane – #646The Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25 Jan 20241h 15min

Knees Over Toes: Fix Knees, Calves, Shins & Shoulders – Ben Patrick : 1127

Knees Over Toes: Fix Knees, Calves, Shins & Shoulders – Ben Patrick : 1127

Meet the man who’s making leaps forward in functional movement training. Ben Patrick (aka the Knees Over Toes Guy) went from chronic knee issues to becoming a dunking sensation with his remarkable 42-inch vertical leap. His journey led him to discover the unconventional “knees over toes” method. He now trains to reverse joint pain and defy aging.In this episode, Ben shares his three game-changing foundations of exercise. We look back at the history of backward walking, and talk about its benefits today. Ben gives us his best tips for strengthening and healing knees, calves, shins, hip flexors, and shoulders. We start from the ground up with fixes for feet and toes. Plus, we talk about the problem with most shoes.Today’s biggest takeaway is recognizing the connection between functional movement and longevity. Functional training is key to how long you live and how well you live. Whether you’re 18 and want to do parkour or you’re 80 and want to get up off the floor—or still do parkour—you’ll want to hear this one. (00:04:45) What’s Up With Knees Over Toes?(00:13:58) Strengthening Joints, Not Just Muscles(00:19:54) Starting Off on the Right Foot(00:28:21) Taking It Back to Basics(00:38:30) Will These Workouts Help or Hurt Your Joints?(00:45:09) Fixes From the Toes Up(00:53:48) How To Have Healthy Hip Flexors(01:00:33) Healthy Movement Patterns for Life(01:03:03:) Secrets To Shoulder Healing(01:05:50) Marketing That Actually Helps PeopleSponsorsQuantum Upgrade | Go to QuantumUpgrade.io/Dave for a 7-day free trialResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: atgonlinecoaching.comATG Equipment: atgequipment.comInstagram: @kneesovertoesguyYouTube: @TheKneesovertoesguy TikTok: @kneesovertoesguyBiohacking Conference: biohackingconference.comThe Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Jan 20241h 12min

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