The Methylene Blue Episode | Solo Biohacking Masterclass : 1366

Get ready for this important download on a fascinating biohacking compound you haven’t heard me talk about before: Urolithin A. It’s a postbiotic that supports the mitochondria, and it’s backed by impressive studies on longevity, anti-cancer effects, cognitive function, and muscle strength. In fact, this compound has earned a place in my permanent stack—which you know isn’t easy to pull off.Today, I chat with Dr. Dominic Denk, who’s done some of the original research on Urolithin A and the company that makes it, Timeline Nutrition powered by Mitopure. Dr. Denk works as a physician in the Department of Internal Medicine at University Hospital Frankfurt. Dr. Denk breaks down what Urolithin A is and how it impacts aging and cancer prevention—answering questions on when, how, and why to take Mitopure—before we delve into the powers of mitochondria, how to have more energy production in your cells, and the relationship between energy production and cancer. We also talk T cells, autoimmunity, and inflammation. Plus, we get into the differences in healthcare and pharmaceutical overreach in the U.S. and Germany. Tune in to uncover the latest life-changing compound—and find out what it will do for your heaviest lift in the gym, your cognition before your next big meeting, and to reverse aging over time. (00:03:31) Understanding Urolithin A (00:08:43) Genetic vs. Mitochondrial Cancer (00:14:48) Getting to the Root of Autoimmunity (00:21:19) Strong Evidence on Muscle Strength (00:23:59) Does Cancer Hate Americans? (00:27:59) Why Do We Age? (00:31:35) The Best Studied Compound You’re Not Taking (00:33:02) Talking T Cells (00:36:22) Healthcare in Germany vs. The U.S. (00:43:31) Urolithin A & Hot/Cold Therapies (00:45:55) Tripling Down on mTOR (00:52:05) Are There Downsides to Urolithin A? ResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Timeline Nutrition: timelinenutrition.com and use code DAVE to save 10%. After January 1st, 2024, TimelineNutrition.com/dave for 30% discount.Mitopure: mitopure.comX: @DomDenkMDLinkedin: Dr.med. Dominic Denk The Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

28 Des 202358min

In this special end-of-year "best of" episode, you'll learn the Top 10 hallmarks of aging, the role of functional medicine in restoring and reversing aging, and the many practical ways you can promote your own longevity.Mark Hyman, M.D., joins Dave in Austin to talk all things longevity. Driven by his desire for a healthier, longer life for himself and others, Dr. Mark immersed himself in the latest scientific research on aging and longevity. Through his findings, he realized that the body has an incredible built-in healing system that can be activated through understanding the emerging science of longevity. He also managed to reduce his biological age by 20 years effectively.He consistently tackles the topic of inflammation and its impact on aging—or “Inflammaging” as he calls it. “The body only has so many ways to say ouch,” Dr. Mark says. “You have pain. You have inflammation. You have certain things that happen that create all these symptoms, but there're these common roots. So, inflammation is this common root that seems to accelerate as we get older. So, we can measure biomarkers of inflammation that are highly predictive of mortality.”This conversation covers many components of aging, like metabolic flexibility and resilience, mTor, meat- and plant-based protein, nutrition, environmental allergies and food sensitivities, histamine, autophagy, fasting, DEXA scans, and much more!In his book, "Young Forever: The Secrets to Living Your Longest, Healthiest Life,” Dr. Mark:shares the knowledge of how to unlock the causes of accelerated aging and treat it as a reversible disease.gives you practical tips for daily habits that will increase your energy and performance.teaches you why you age and what it really takes to live a longer, more vibrant life.Watch this episode on YouTube! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Des 20231h 8min

In this episode of The Human Upgrade you’ll meet Robert Waldinger, M.D., who leads an extraordinary scientific study on happiness that’s still going strong after eight decades. The study set out to understand human health by what made people thrive.Since 1938, the Harvard Study of Adult Development has tracked two groups of men and their families with the goal of discovering what really makes for a good life. Along the way, thousands of questions were asked, and hundreds of measurements were taken—from brain scans to blood work. Three strong themes emerged from the study: Social connections are really good for you. Loneliness kills.It’s the quality of your close relationships that matters.Good close relationships don’t just protect your body, they protect your brain.Dr. Waldinger combined those lifelong case studies with modern psychological research in his new book, co-authored with Marc Schulz, Ph.D., “The Good Life: Lessons from the World's Longest Scientific Study of Happiness." This discussion gives you real-life tools to hack your happiness. You’ll learn things like:how relationships improve your physical, mental and emotional health. (More than you know!)how to evaluate the effect of your relationships on your well-being. (Don’t be dragged down.)what social fitness is and how to practice it. (Yes, it’s a flex.)ways to enliven and energize your relationships. (Energy totally matters.)why casual and work relationships matter more than you think. (A surprisingly big contribution.)Watch this episode on YouTube!Don’t Miss This! Dr. Waldinger’s TEDtalk about the study is one of TED’s Top 10 episodes and viewed more than 43 million times.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

21 Des 20231h 13min

This episode is a deep dive into the heart of modern fitness, led by one of its most influential figures. Joining me today is Lavinia Errico, the visionary co-founder of Equinox Fitness Clubs. Lavinia isn't just a pioneer in the fitness industry, she's a passionate advocate for a life that's healthier, more fulfilled, balanced, and brimming with joy. She's dedicated to helping others achieve these same goals, inspiring people to delve into self-awareness and embrace transformative journeys. With her belief in enjoying the journey and embracing the process, Lavinia has shaped not just her own life but the lives of countless others towards seeing, feeling, and living remarkable results.Today, you’ll hear about how Lavinia's career in fitness and biohacking began with the birth of the modern fitness movement and Equinox as she shares challenges and triumphs of starting a fitness revolution in 1980s New York. You’ll also learn about the unique ethos that set Equinox apart and how building a business with family shaped its upward trajectory.This conversation is threaded with insight into the life of an entrepreneur, the realities of being a CEO, and how Lavinia intuitively balanced her professional journey with motherhood. Lastly, you’ll get a taste of Lavinia's wellness rituals, her philosophy as a lifelong learner, and her exciting new chapter with MOVEJOY, aimed at creating a more stress-free, joyous workout experience for everyone. (00:01:41) Laying the Foundation of Equinox(00:10:44) Finding the Joy of Movement(00:18:56) Advice for Women in Business(00:24:51) The Honest Cost of Being an Entrepreneur & CEO(00:32:14) Wellness Rituals & Being a Student of Life(00:44:47) Introducing Move Joy(00:55:27) Shifting the Why Behind MovementResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: movejoy.lifeInstagram: @laviniajoyLinkedIn: Lavinia ErricoThe Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Des 20231h 4min

Today is a long-awaited show with none other than Bryan Johnson, an entrepreneur, venture capitalist, author, and professional rejuvenation athlete on a mission to discover the next evolution of humankind. While Bryan is well known in the longevity space, I’ve been a fan of his work for years because of his neuroscience background. Bryan started a company called Kernel, which makes devices that monitor and record brain activity. Kernel uses what I would call the most comprehensive way of looking at the human brain ever. He is the founder of OS Fund and Braintree, and he spearheads Project Blueprint, an anti-aging experiment where he’s spent multiple years and millions of dollars developing an algorithm to live longer. In today’s wide-ranging talk, we discuss the future of optimizing our brains with AI—delving into all things biohacking and longevity while exploring complicated questions like… Can you die of loneliness? And… Are your critics making you old?Plus, we talk testosterone—an often triggering topic, but an essential conversation. Bryan shares his perspective on why he would rather be respected by people in the 25th century than understood now. Stick around for his surprising takes on olive oil, body hair, and saunas. (00:59) Biohacking The Brain (05:34) Are Your Critics Making You Old?(12:52) What Makes Bryan Tick(20:09) The Longevity-Loneliness Connection (28:27) Accounting For Bio Individuality in Health Protocols (39:09) Does Having a Partner Help You Live Longer? (47:59) Olive Oil vs. Saturated Fats (54:39) Talking Testosterone (01:07:52) Expanding Consciousness with Psychedelics (01:12:06) Questions from the Live Audience Sponsor: Try Qualia NAD+ with an extra 15% off with code Dave15.Resources:Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: protocol.bryanjohnson.comKernel: kernel.comRead: Don’t Die by Zero Instagram: @bryanjohnson_ YouTube: Bryan Johnson Linkedin: Bryan Johnson The Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14 Des 20231h 26min

Coming to you live from Austin, Texas, I can’t wait for you to meet Dan Freed—a man who’s journeyed from the hot kitchen of high-end cooking to the frontier of brain improvement. Dan’s the founder and CEO of Thesis, a company that's revolutionizing the way we think about our brain's potential, and his journey is one of resilience and innovation. Picture this… A kid struggling with focus throughout childhood, he drops out of high school and claws his way up in the ruthless restaurant industry to become a saucier in a three-star Michelin kitchen. But the real twist comes when Dan, grappling with burnout, stumbles upon cognitive performance supplements. This discovery didn't just change his mental game, it transformed his entire life. Fast forward through degrees from Yale and INSEAD, and you have the Dan that sits down for this interview—committed to helping others harness their brainpower to the fullest.We get into the nitty gritty of nootropics and the supplement industry, talking about how Dan's fight with burnout and learning challenges led to the birth of Thesis Nootropics. We share tips on adapting human biology to our modern world, discuss the thorny issues of regulation and quality in the supplement industry, and explain how Thesis uses a unique combined approach of customizing nootropics and expert support for their customers. We round it all off with a look at the remarkable, results-driven formulas that Thesis offers, and how focus is the key to unlocking our greatest potential. Dan's story is a living proof that sometimes, a couple of stumbles can lead to an incredible leap forward, thanks to some conscious action. That’s the kind of journey we all can learn something from.(00:02:14) How Burnout & Learning Challenges Inspired Thesis Nootropics(00:19:15) Is Using Nootropics Cheating?(00:25:37) Tips for Adapting Human Biology to the Modern World(00:32:33) How Thesis Is Customizing Nootropics(00:40:59) Tips for Supporting Your Body’s Homeostasis While Taking a Stimulant(00:46:33) Dave Rings the Alarm on Formulating With Vitamin B6(00:50:53) Regulation & Quality Concerns in the Supplement Industry(00:57:41) Key Ingredients in Thesis’ Clarity & Logic Formulas That Drive Real Results(01:04:28) Unlocking Your Potential Through the Power of FocusResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: takethesis.com and use code “Asprey” for a 10% off all Thesis products.Instagram: @takethesisFacebook: Take ThesisThe Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Des 20231h 12min

Cynthia Thurlow joins the show to talk about how intermittent fasting can help women change their body, metabolic system and brain function. She has tips for women at all stages: from active menstrual cycles to perimenopause to menopause.Cynthia is a Johns Hopkins-trained nurse practitioner and functional nutritionist founded and serves as CEO of Everyday Wellness Project. She holds a Master of Science degree in Nursing and Functional Nutrition certifications with advanced trainings in Endocrinology and Gastroenterology. Her career in healthcare includes nearly 20 years of emergency medicine and cardiology experience. She brings a broad perspective when working with women to improve the state of their health. “I really start from a foundational level talking to women about fasting,” Cynthia says. “It's really honoring our own unique physiology. It's leaning into that menstrual cycle. It's leaning into the lifestyle piece that so much of us forget to talk about with our patients, our sleep quality, stress management, anti-inflammatory nutrition, our exercise quality, our connection with nature, all of which are critically important.”She also addresses diet dogma that frustratingly persists, even with established and emerging science about the benefits of intermittent fasting.She tackles this outdated dogma (and a lot more!) in her new book, “Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.”“[Intermittent fasting] restores our intrinsic rhythms, burns fat, regenerates our health right down to the cellular level, and stabilizes our hormones,” Cynthia says in her book. “In turn, we are less likely to develop obesity, diabetes, vascular diseases, and autoimmune disorders.”At the end of this conversation, you’ll have the tools to decide if intermittent fasting is the right choice for the state of your own health.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Des 20231h 5min

Dive into a captivating exploration of human biology and connection—erotic blueprints. Discover four primal drivers: fear, food, friends, and fertility, with a unique focus on fertility in this episode.Miss Jaiya, a leader in somatic sexology, sheds light on the intimate realm of human relationships and pleasure. As an award-winning somatic sexologist and creator of The Erotic Blueprints® Framework, Jaiya dedicates her expertise to helping people understand their unique erotic blueprints and their impact on intimate lives. Her latest book, "Your Blueprint for Pleasure," offers invaluable insights into a revolutionary language for bedroom communication and sexual vitality.This episode delves into the concept of erotic blueprints, Jaiya's research, and the unique paths to turn-on and blissful gratification for each individual. This conversation aims to understand people's true desires and needs in intimate relationships, free from taboos or judgment.Highlighting that sex and intimacy are vital for well-being, just like food and breathing, this discussion includes personal experiences and emphasizes the importance of vulnerability. Learn how understanding your erotic blueprint can enhance connections and satisfaction in the bedroom.Whether seeking to enrich intimate life or deepen understanding of human biology and connection, this episode offers valuable insights for everyone.(01:34) Reconciling Spirituality & Sexuality: Jaiya’s Sexual Empowerment Journey(12:00) Why Sex Is the New Frontier of Personal Growth & Biohacking(15:25) Jaiya’s Wildest Energetically Erotic Experience(21:35) Conscious Kink & Blending Psychedelics With Sexuality(30:52) Your Pleasure Blueprint: Defining the 5 Erotic Types(34:55) Discovering the Erotic Blueprint Through Her Own Relationship(40:01) Addressing the Intimacy Issue in Our World & Sending Love Through the Field(46:44) Confronting the Taboo of Pleasure(52:11) Mastering Energetic Sexuality & Orgasms(01:01:48) Risks in Using Psychedelics for Creation Energy(01:06:49) The Dark Side of Spiritual Ecstatic Altered States & How To Protect Your FieldResourcesDave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: blueprintbreakthrough.comRead: Your Blueprint For Pleasure by Jaiya Instagram: @missjaiyaThe Human Upgrade is produced by Crate Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Des 20231h 24min