10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



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• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

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Episoder(1432)

Lions, Dolphins and Bears, Oh My! With Michael Breus

Lions, Dolphins and Bears, Oh My! With Michael Breus

Description not available at this time, check back later See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Sep 20161h 11min

Mind, Buddha, Spirit with Dan Harris

Mind, Buddha, Spirit with Dan Harris

Dan Harris is the author of the #1 New York Times Bestseller 10% Happier: How I Tamed the Voice in My Head, Reduced Stress Without Losing My Edge, and Found Self-Help That Actually Works-A True Story. He's is the co-creator of the 10% Happier: Meditation for Fidgety Skeptics app and the host of the podcast 10% Happier with Dan Harris. Dan is also a co-anchor for ABC News' Nightline and for the weekend edition of Good Morning America. On this episode of Bulletproof Radio, Dan and Dave talk about meditation and mindfulness, Buddhism, spirituality and religion, breathing exercises, podcasting and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Sep 20161h 5min

Say GeNOme to Cancer with David Haussler

Say GeNOme to Cancer with David Haussler

David Haussler is a human genome expert and developer of new statistical and algorithmic methods to explore molecular function, evolution and disease process in the genome. David and his team posted the first publicly available computational assembly of the human genome sequence as collaborators on the international Human Genome Project. On today's episode of Bulletproof Radio, David and Dave give advice on avoiding cancer, immunotherapy and other new treatment, hormonal Vitamin D, genome sequencing and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Sep 20161h 11min

50 Shades of Dave with Mistress Natalie

50 Shades of Dave with Mistress Natalie

Mistress Natalie is a professional dominatrix and life coach to entrepreneurs. Before becoming a full-time dominatrix, she was an entrepreneur with several successful businesses under her belt. Over the course of several sessions with her clients she began to see the therapeutic value of BDSM and decided to go back to school to get accredited as a life coach. Her "Kinky Coaching" uses BDSM along with several biohacking principles as tools to elevate a person's mental and physical state, increase neurofeedback and run a successful business. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Sep 20161h 21min

Owning Your Testosterone with John Romaniello – #340 : 340

Owning Your Testosterone with John Romaniello – #340 : 340

John Romaniello is the New York Times bestselling fitness author of Man 2.0 Engineering the Alpha: A Real World Guide to an Unreal Life and a superhero fitness geek. He has been featured on programs such as Good Morning America, and is an adviser to nearly a dozen fitness and tech companies. On today’s episode of Bulletproof Radio, Dave and John talk about proper testosterone use, sleep cycles, chronotypes, understanding hormone levels and more. Enjoy the show!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

30 Aug 201645min

Cancer's Ketogenic Kryptonite with Patricia Daly

Cancer's Ketogenic Kryptonite with Patricia Daly

Patricia Daly is a fully-qualified nutritional therapist based in Dublin, Ireland. Following her cancer diagnosis, she left her corporate career and started studying nutrition, specializing in the area of Integrative Cancer Care. As a Swiss native, she regularly attends training courses in Switzerland/Germany, including at the renowned Tumor Biology Center in Freiburg, Germany. She's working on a new book on the benefits of the low carb and ketogenic diet, which she's co-writing with Irish foodwriter Domini Kemp. On today's episode of Bulletproof Radio, Patricia and Dave talk about the ketogenic diet, tips for battling cancer, lights to avoid, hormonal irregularities, grounding, her story of overcoming cancer and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Aug 20161h 2min

These Ain't Your Neighbor's Stem Cells with Dr. Tami

These Ain't Your Neighbor's Stem Cells with Dr. Tami

Close friend and Bulletproof Radio veteran Dr. Tami Meraglia joins Dave in Bulletproof Labs for this episode of Bulletproof Radio. Dr. Tami runs the Vitality Medi Spa, a hormonal treatment center in Seattle. She's the author of Hormone Secret, and recently opened a stem cell treatment center in Seattle as well. On this episode of Bulletproof Radio, Dave and Tami talk about testosterone imbalance, relationships, nitro oxide, light treatment, oxytocin, adrenal health, the thyroid and more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Aug 20161h 14min

Dave on The Adam Carolla Show

Dave on The Adam Carolla Show

On this special episode of Bulletproof Radio, Dave is the one being interviewed. A little while back, Dave made an appearance on perhaps the most popular podcast out there, The Adam Carolla Show. Listen to Adam and his team hilariously pick Dave's brain on topics like his Bulletproof Diet, daily eating, politics within the food industry, unlearning dietary habits, steakhouses, halva and more. Enjoy the show! Head on over to The Adam Carolla Show on PodcastOne to check out this episode in full and all of their episodes, and catch Adam and his team in a city near you for one of their live podcast recordings. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Aug 201638min

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