10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


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• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

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Episoder(1429)

Winter Q&A: Coffee Cycling, Gallbladder Surgery & More - #269

Winter Q&A: Coffee Cycling, Gallbladder Surgery & More - #269

In this episode of Bulletproof Radio, we've selected the best questions that Bulletproof fans submitted via our voicemail service, Facebook and the Bulletproof® Forums, for another awesome Q&A. Hear Dave answer questions with Dr. Mark Atkinson about the Bulletproof Coaching program, how to build muscle while losing fat, tips to take care of your gallbladder/what to do if you have had your gallbladder removed, and how to manage high blood pressure. This episode covers a variety of topics based on your questions. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Des 20151h 9min

Evan Brand: Forest Bathing, Repairing Your Vision & Adaptogens - #268

Evan Brand: Forest Bathing, Repairing Your Vision & Adaptogens - #268

Evan Brand is a Certified Nutritional Therapist and Personal Trainer who specializes in functional lab testing, targeted supplement programs, nutrition and lifestyle counseling to support true health and happiness. He works with clients all across the globe and offers complimentary phone or Skype consultations along with a free chapter of his best-selling book, Stress Solutions at NotJustPaleo.com. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Des 20151h 7min

Jim Kwik: Boost Brain Power, Upgrade Your Memory - #267

Jim Kwik: Boost Brain Power, Upgrade Your Memory - #267

Jim Kwik is the founder of Kwik Learning and is a widely recognized world expert in speed-reading, memory improvement, brain performance and accelerated learning. Jim has dedicated his life to helping others unleash their true genius and brainpower to learn anything faster and live a life of greater power, productivity and purpose. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Des 201550min

Reed Davis: Master Your Lab Results - #266

Reed Davis: Master Your Lab Results - #266

Reed Davis joins the show to discuss how functional laboratory assessments identify underlying conditions at the root of most common health complaints. He shares how to treat systems, not symptoms, to feel better. Reed Davis is the Founder of the Functional Diagnostic Nutrition® (FDN) Certification Course. He is known as one of the most successful and experienced clinicians in the world, having provided functional lab assessments to over 10,000 clients for hormone, adrenal, digestive, immune and detoxification issues as well as infections, infestations, food sensitivities and chronic stress-related problems. Reed served as a Health Director and Case Manager for over 15 years and now teaches a course in functional medicine with over 2,000 trainees in 50 countries. He is also a Clinical Advisor at BioHealth Laboratory where he helps doctors interpret lab test results and develop natural protocols to restore function instead of just treating the symptoms. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

8 Des 20151h 12min

Walter Crinnion: Toxicants Role On Fertility, Weight Gain & Mental Health #265

Walter Crinnion: Toxicants Role On Fertility, Weight Gain & Mental Health #265

Bulletproof Radio welcomes Walter Crinnion, a Naturopathic Doctor with over 30 years of medical experience and an expert in the field of environmental medicine. Walter shares how excessive environmental toxicants are leading to autism, autoimmune diseases and weight gain and what to do about it. Walter Crinnion received his Naturopathic Doctor degree in the first graduating class from Bastyr University in 1982 and went on to develop the most comprehensive cleansing facility in North America in the Seattle area. Individuals at the facility were able to reduce their body burden of environmental toxicants and recover their health - with spontaneous remissions of all autoimmune disorders, certain cancers, chemical sensitivity, fibromyalgia, Parkinsonism and even ALS. Dr. Crinnion has been a faculty member at four different Naturopathic Medical Schools and was the founding department chair for Environmental Medicine at the Southwest College of Naturopathic Medicine (Tempe, AZ) from 2003-2013. He now focuses on training other healthcare professionals in Environmental Medicine. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Des 20151h 7min

Stephen Porges: The Polyvagal Theory & The Vagal Nerve #264

Stephen Porges: The Polyvagal Theory & The Vagal Nerve #264

Stephen Porges comes to Bulletproof Radio to share his pioneering research on the vagus nerve, how the cues it receives play a major role in stress, social behavior and the nervous system and some tips on how to improve its response. Dr. Porges is a Distinguished University Scientist at Indiana University where he directs the Trauma Research Center in the Kinsey Institute. He is Professor of Psychiatry at the University of North Carolina, Professor Emeritus at the University of Illinois at Chicago, where he directed the Brain-Body Center in the Department of Psychiatry, and Professor Emeritus at the University of Maryland, where he chaired the Department of Human Development and directed the Institute for Child Study. In 1994 he proposed the Polyvagal Theory, a theory that links the evolution of the mammalian autonomic nervous system to social behavior and emphasizes the importance of physiological state in the expression of behavioral problems and psychiatric disorders. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Des 201558min

Lisa Bloomquist: Know Your Antibiotics & Restore Your Mitochondria #263

Lisa Bloomquist: Know Your Antibiotics & Restore Your Mitochondria #263

Lisa Bloomquist joins Bulletproof Radio to discuss her devastating experience with Ciprofloxacin, the important role of mitochondria and how to choose a safer antibiotic. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25 Nov 20151h 5min

Brendon Burchard: Hacking High Performers & Productivity Tricks #262

Brendon Burchard: Hacking High Performers & Productivity Tricks #262

Keynote of the 3rd Annual Bulletproof Biohacking Conference, Brendon Burchard sat down just after his presentation, to discuss how to be more productive every day with one easy trick, setting your intentions with a "doorframe trigger," the 5 things you need to be successful and Your Next Bold Move course on Oprah.com. Enjoy the show! Brendon Burchard is founder at the High Performance Academy, host of The Charged Life Podcast, and author of the #1 New York Times Bestsellers, The Motivation Manifesto, The Charge, and The Millionaire Messenger. Brendon has the #1 rated personal development show on YouTube, is one of the top-100 most followed public figures on Facebook, and he's shared the stage with other notable speakers such as Tony Robbins, Richard Branson, the Dalai Lama, Steve Forbes, and Katie Couric. His educational work has helped millions of people around the globe achieve the results they are looking for in the areas of business, marketing, and personal development, and his programs like the Experts Academy and World's Greatest Speaker Training have helped to jump-start thousands of people on the way to the careers they dream about. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Nov 201542min

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