430: Proterozoic Rise: Steady Diversification of Crown Eukaryotes
Sandin MM et al., Proceedings of the National Academy of Sciences - Molecular clocks and diversification models applied to a 75,975-OTU rDNA dataset, including long-read environmental sequences and 77...
23 Jul 25min
429: Validating the EAGL genetic literacy measure
Barna LS et al., Human Genetics and Genomics Advances - We summarize a psychometric validation of the EAGL measure using US adult online samples. The study produced a validated 17-item EAGL-short that...
23 Jul 23min
428: Genetic regulation of plasma metabolites in people with HIV
Ait Oumelloul M et al., Human Genetics and Genomics Advances - Untargeted plasma metabolomics (1,930 features) in 1,244 participants of the Swiss HIV Cohort Study were paired with genome-wide genotype...
23 Jul 28min
427: When Genes Talk to Gut: Microbiome as Mediator of Metabolic Risk
Simpson RC et al., Trends in Genetics - This forum reviews evidence that host genetic variants associated with metabolic disease often overlap with loci that shape gut microbiome composition and funct...
23 Jul 25min
426: ProtoCloud — Prototypical self-explaining model for single-cell analysis
Guo K et al., Cell Genomics - ProtoCloud is a self-explaining deep generative model that embeds single cells around cell-type-specific prototypes to deliver accurate, uncertainty-aware cell type annot...
23 Jul 16min
425: BEAM: Bayesian reconstruction of metastatic migration histories
Staklinski SJ et al., Cell Genomics 6, 101193 (2026) - This episode explores BEAM, a Bayesian framework built on BEAST 2 that jointly infers cell-lineage phylogenies and tissue-migration graphs from C...
23 Jul 23min
424: LECA's Ancient Interactome and Modern Disease
Cox RM et al., Cell Genomics 6, 101254 - Cox et al. reconstruct a conserved protein interaction network for the last eukaryotic common ancestor using >26,000 mass spectrometry experiments across 31 sp...
23 Jul 12min
423: How GRN Topology Shapes the Genetic Architecture of Expression
Aguirre M et al., Cell Genomics - Aguirre et al. use simulated gene regulatory networks and a linear structural equation model to show how sparsity, modularity, and hub regulators shape the genome-wid...
22 Jul 25min
