414: Durability of Cas9 Gene Drives in Anopheles: A 2‑Year Cage Study
Carballar-Lejarazúa R et al., PNAS (2026) - This episode summarizes a 2-year, 35-generation multireplicate cage trial evaluating three autonomous Cas9/gRNA gene-drive strains (AcTP13, AcTP43 in Anophe...
17 Jul 31min
413: Rpc34 WH2 dynamics in RNA polymerase III
Wu J-S et al., PNAS - A PNAS study using smFRET and nano-positioning triangulation maps dynamic positioning of the Rpc34 WH2 domain in yeast Pol III elongation complexes and presents a thiol-capping S...
12 Jul 15min
412: Fault Lines in Forensic Proficiency Testing
Scurich N et al., PNAS - A concise breakdown of a PNAS perspective that analyzes forensic proficiency testing practices using the 2023 CTS firearms test as a case study. The authors identify test desi...
12 Jul 28min
411: EKV cells and the Human Prion Assay: a scalable platform for sCJD infectivity
Nihata A et al., PNAS - This PNAS study describes the development of EKV, a humanized dividing cell line that propagates bona fide sporadic CJD (sCJD) prions, and the Human Prion Assay (HPA), a cell-b...
9 Jul 26min
410: Nucleotide diversity is a poor predictor of short-term adaptive potential
Abson KL et al., PNAS - A cross-species synthesis and theory paper showing that simple molecular diversity metrics poorly predict short-term adaptive potential. The authors compiled >2,100 quantitativ...
8 Jul 21min
409: A systems-level atlas of carbon-response transcriptional states in Escherichia coli
Shin J et al., PNAS - This episode examines a large transcriptome compendium (PRECISE-NP881) that profiles E. coli K-12 MG1655 across 43 carbon substrates. Independent component analysis resolved 137 ...
7 Jul 27min
408: Tau, mitochondria, and the fusion switch
Tsakiria E et al., Proceedings of the National Academy of Sciences (PNAS) - Using Tau knockout mice and the C. elegans PTL-1 deletion, this study shows that loss of wild-type Tau promotes a conserved ...
6 Jul 24min
407: SLC11A2 withholds metals from Salmonella in the gut epithelium
Norberg ES et al., Proceedings of the National Academy of Sciences - Using metal‑responsive fluorescent Salmonella reporters, calf intestinal loops, and CRISPR edited epithelial cells, this study show...
5 Jul 21min
