Base by Base

Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.

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Episoder(441)

201: Sex, Smoking, and Somatic Selection in the Bladder

201: Sex, Smoking, and Somatic Selection in the Bladder

Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09521-x License:This episode is based on an open-access article published under the Creative Commons Att...

17 Nov 202514min

200: Sperm Sequencing Reveals Extensive Positive Selection in the Male Germline

200: Sperm Sequencing Reveals Extensive Positive Selection in the Male Germline

Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09448-3 License:This episode is based on an open-access article published under the Creative Commons Att...

16 Nov 202518min

199: PLD4 Deficiency and Lupus: When Nuclease Failure Ignites Autoimmunity

199: PLD4 Deficiency and Lupus: When Nuclease Failure Ignites Autoimmunity

PLD4 Deficiency and Lupus: When Nuclease Failure Ignites Autoimmunity Music:Enjoy the music based on this article at the end of the episode. License:This episode is based on an open-access article p...

15 Nov 202513min

198: Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells

198: Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells

Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells Music:Enjoy the music based on this article at the end of the episode. License:This episode is based on an open-access article pu...

14 Nov 202515min

197: Somatic Mutation and Selection at Population Scale

197: Somatic Mutation and Selection at Population Scale

Somatic Mutation and Selection at Population Scale Music:Enjoy the music based on this article at the end of the episode. License:This episode is based on an open-access article published under the ...

13 Nov 202515min

196: Impact of Chromatin Accessibility QTLs Across Immune Contexts

196: Impact of Chromatin Accessibility QTLs Across Immune Contexts

Impact of Chromatin Accessibility QTLs Across Immune Contexts Music:Enjoy the music based on this article at the end of the episode. License:This episode is based on an open-access article published...

12 Nov 202516min

195: Tiny Shields: Lymphoid Microglia in Alzheimer’s Disease

195: Tiny Shields: Lymphoid Microglia in Alzheimer’s Disease

Music:Enjoy the music based on this article at the end of the episode. Support:Base by Base is independent and ad-free — no sponsors, no paywall. If an episode was worth your time, chip in and keep t...

11 Nov 202518min

194: Bayesian History of Science: Watson and Crick and the Structure of DNA

194: Bayesian History of Science: Watson and Crick and the Structure of DNA

️ Episode 194: Bayesian History of Science: Watson and Crick and the Structure of DNA In this episode of PaperCast Base by Base, we explore how Bayesian reasoning can be used to reconstruct the famous...

10 Nov 202514min

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