Base by Base
VitenskapHelse

Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.

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Episoder(441)

193: SARM1, DNA, and the Death Signal

193: SARM1, DNA, and the Death Signal

️Episode 193: SARM1, DNA, and the Death Signal In this episode of PaperCast Base by Base, we explore how the axon-degenerating enzyme SARM1 acts as a double-stranded DNA sensor that triggers NAD+ loss...

9 Nov 202515min

192: At Base-Pair Resolution: Chromatin’s Cis-Regulatory Conversations

192: At Base-Pair Resolution: Chromatin’s Cis-Regulatory Conversations

️Episode 192: At Base-Pair Resolution: Chromatin’s Cis-Regulatory Conversations In this episode of PaperCast Base by Base, we explore how base-pair resolution maps of chromatin contacts reveal a unifi...

8 Nov 202514min

191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI

191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI

️ Episode 191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI In this episode of PaperCast Base by Base, we explore a Nature Communications study that proposes CATphis...

7 Nov 202519min

190: dGCNA and single-cell maps reveal cell-type mechanisms in T2D

190: dGCNA and single-cell maps reveal cell-type mechanisms in T2D

Martínez‑López JA et al et al., Nature Communications - This episode examines a Nature Communications study that introduces differential Gene Coordination Network Analysis (dGCNA) applied to deep Smar...

6 Nov 202515min

189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms

189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms

️ Episode 189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms In this episode of PaperCast Base by Base, we explore how genome-wide DNA methylation profiling can p...

5 Nov 202514min

188: Proteomics + Machine Learning for Lyme Neuroborreliosis Diagnosis

188: Proteomics + Machine Learning for Lyme Neuroborreliosis Diagnosis

️ Episode 188: Proteomics + Machine Learning for Lyme Neuroborreliosis Diagnosis In this episode of PaperCast Base by Base, we explore how large‑scale mass‑spectrometry proteomics of cerebrospinal fl...

4 Nov 202516min

187: Gapped scheduling: CRLX101 + olaparib Phase I trial

187: Gapped scheduling: CRLX101 + olaparib Phase I trial

Nature Communications (2025) 16:9457 et al., Nature Communications - Phase I dose-escalation trial combining CRLX101 (nanoparticle camptothecin) with olaparib using a 48-hour gapped schedule in 24 pat...

3 Nov 202516min

186: TNFα–TGFβ Axis Disrupts Nasal Epithelium in Post‑COVID Syndrome

186: TNFα–TGFβ Axis Disrupts Nasal Epithelium in Post‑COVID Syndrome

️ Episode 186: TNFα–TGFβ Axis Disrupts Nasal Epithelium in Post‑COVID Syndrome In this episode of PaperCast Base by Base, we explore a single‑cell RNA‑seq study of nasal biopsies showing that persist...

2 Nov 202515min

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