56: When the Immunoproteasome Turns Toxic: PSMB8, PFKFB3 and Ferroptosis in MS
Woo et al et al., Cell - This study shows that interferon-driven induction of the immunoproteasome subunit PSMB8 in neurons reduces proteasome β5 catalytic activity, causing accumulation of the glycol...
26 Jun 202516min
55: Denisovan DNA from the >146,000-year-old Harbin cranium
Fu Q et al., Cell - Recovery of mitochondrial DNA from dental calculus links the Late Middle Pleistocene Harbin cranium to Denisovans and demonstrates dental calculus as a source of ancient host DNA. ...
25 Jun 202514min
54: Immune trajectories in COVID-19 among patients with end-stage kidney disease
Stephenson E et al., Cell Genomics - Longitudinal single-cell multi-omics profiling of PBMCs from 61 end-stage kidney disease (ESKD) patients with COVID-19 (580,040 cells) reveals distinct temporal im...
24 Jun 202518min
53: Weighing PRS: costs, benefits, and evidence
Siena LM et al., The American Journal of Human Genetics - A systematic review of 24 full economic evaluations assessing polygenic risk score (PRS)–based clinical strategies across cancer, cardiovascul...
23 Jun 202517min
52: LIZS6 methods and measurements
Keener R et al., Cell Genomics - A method-focused excerpt describing LIZS6-related experiments across multiple conditions (NoSk, LSFM) with quantitative readouts and protocol detail. Key terms: LIZS6,...
22 Jun 202516min
51: Finding Hidden mtDNA Diagnoses in Solve-RD
Ratnaike et al et al., The American Journal of Human Genetics - This episode reviews a Solve-RD reanalysis that integrated an mtDNA-focused bioinformatic pipeline (MToolBox) with MitoPhen HPO-based ph...
21 Jun 202517min
50: Translating the Microbiome to the Clinic
Porcari S et al., Cell - Perspective reviewing current diagnostic and therapeutic advances in gut microbiome research and outlining the methodological, biological, regulatory, and educational actions ...
19 Jun 202517min
49: Chitin as a reservoir: DNA adsorption and gene transfer in Vibrio cholerae
Holt JD et al., PNAS - Using microfluidic flow assays and live-cell imaging, the authors show that environmental DNA adsorbs to chitin particles and that Vibrio cholerae can retrieve this chitin-bound...
18 Jun 202522min
