48: Mainstreaming Clinical Genetic Testing: A Framework for Care
Mackley MP et al., Genetics in Medicine - A consensus-driven conceptual framework from Canadian genetics experts describing four models for mainstreaming clinical genetic testing and the variables tha...
16 Jun 202516min
47: Encoding and decoding chemokine-GPCR selectivity
Kleist AB et al., Cell - A data-driven mapping of how 46 human chemokines and 23 GPCRs encode selective and promiscuous interactions. The team defines conserved, semi-conserved and variable determinan...
16 Jun 202522min
46: How tRNA modifications tune m6A-dependent mRNA decay
Linder B et al., Cell - This episode explores a pan-epitranscriptomic mechanism showing how m6A in coding sequences slows ribosomal decoding to trigger translation-dependent mRNA decay, and how the tR...
14 Jun 202520min
45: RNA-dependent mechanics of nucleolar subcompartments
Cheng HH et al., Proceedings of the National Academy of Sciences (PNAS) - Using micropipette aspiration in Xenopus laevis oocyte nuclei, authors show the nucleolar granular component behaves as a liqu...
12 Jun 202520min
44: Polε Proofreading Revealed
Wang F et al., PNAS - This episode examines a cryo-EM study that captures authentic proofreading intermediates of human Polε in complex with PCNA by generating a mismatch in situ. The work reveals how...
12 Jun 202519min
43: Population heterogeneity, insulin sensitivity, proteome & signaling mapping
Kjærgaard J et al., Cell - This episode reviews a study that links in vivo insulin sensitivity phenotyping with proteome and signaling-pathway mapping to define molecular-phenotype associations across...
11 Jun 202519min
42: Amino acids catalyse RNA formation under ambient alkaline conditions
Rout SK et al., Nature Communications - A Nature Communications study shows that proteinogenic amino acids accelerate non-enzymatic RNA oligomerisation from ribonucleoside-2',3'-cyclic phosphates unde...
11 Jun 202523min
41: Valuing Genomic Newborn Screening: Australian Public Preferences
Peters R et al., The American Journal of Human Genetics - This episode reviews a nationwide survey of 2,509 Australian adults using two discrete choice experiments to quantify public preferences and t...
10 Jun 202518min
