The Human Upgrade: Biohacking for Longevity & Performance

This episode of Bulletproof Radio is part two of a special two-part series. (Catch part one here.) There was a lot to discuss about Covid-19 with Mansoor Mohammed, Ph.D., president and chief scientific officer of The DNA Company. He’s widely regarded as a pioneer in medical genomics.In part two, we talk about specific genes that make you prone to exaggerated inflammatory viral responses and respiratory problems. The DNA Company actually knows this. In fact, Mansoor and I had a conversation about this long before Covid-19 existed. We again get scienc-y about DNA and coronavirus, but we explain it all along the way in simple terms. We break down the science into manageble pieces that you can use today. Especially when it comes to inflammation, which is one of the pandemic ripple effects.“Ultimately the real knockout punch is coming from something called cytokine storms, which is just a sexy word of seeing a deregulated hyped-up, armed-up inflammatory response,” Mansoor says.Whether you have access to your genetic information or not, this episode offers something for everyone to make sure this inflammatory thing doesn't hit you.We look at stacking Selenium, Zinc, D3, Vitamin C and NAC, as well as balancing your methylation. However, this is just a start. Buckle up to learn a lot more!Like YouTube? Watch a trio of this episode’s Podcast BulletPoints on our Bulletproof Radio YouTube channel.Missed part one of this two-part series? Find it here.Explore our podcast topics.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

16 Apr 202051min

This episode of Bulletproof Radio is part one of a special two-part series. There was a lot to discuss about Covid-19 with Mansoor Mohammed, Ph.D., president and chief scientific officer of The DNA Company.Today’s guest is widely regarded as a pioneer in medical genomics and has been the recipient of multiple academic and industry awards. He’s the holder of several patents in the general fields of molecular diagnostics and genomics research. Now you might think that we’re going to get into something scienc-y about DNA and coronavirus—and we are, but there’s so much more to consider. For example, how DNA impacts your ability to fight Covid-19 and the vast ripple effect this pandemic is having across the world. There’s also an emotional effect, secondary to the pandemic, that very few people are talking about in any meaningful way.Hardcore stress, anxiety, social isolation, employment and education disruption, and safety and security concerns are moving in waves across the world. Cortisol levels are up, inflammation is triggered, circadian rhythms are off, eating habits are upset—all making for a swirling storm of physical and mental health concerns beyond having the actual virus. For all of us.And while it seems the Covid-19 illness doesn’t seem to be affecting youth as much as adults, we may be “leaving the youth out of the equation,” says Mansoor. “But those youth are equally likely to be affected by the emotional discord of seeing mom and dad scared, mom and dad fighting, parents worried, and they may not have the barometers by which to filter all of the stress that's societally going on.”Turns out there’s a genetic link to how we process trauma. A percentage of our youth have a “profound genomic makeup that significantly predisposes them to a much more anxiety based, much more war-based response to what's going on,” Mansoor says. Adults are not immune, either. I had Mansoor check my own DNA; listen on to what he found.“We're performing a societal experiment right now,” Mansoor continues. “And we need to be aware of this and we need to be aware of the multitude of effects this is going to have—not just acute viral infection and acute hospitalization. There are broader effects here that we need to speak of.”Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14 Apr 202047min

Don't miss this special—and slightly longer—episode of Bulletproof Radio. My guest has defied incredible odds throughout her life to accomplish some extraordinary things.Amy Purdy follows a road of her own making—as a motivational speaker, a New York Times best-selling author, a model, dancer and actress—and also the most decorated American Paralympic snowboarder in history.She toured the United States with Oprah Winfrey, speaking to stadiums of people about her life: losing both legs at 19. By sharing her incredible story, she taught others about resilience and inspired them to follow their dreams.Her life took another turn in 2019—this time a severe health setback. We’re going to talk about what happened and how she hacked her body and mind through her recovery.When it comes to excruciating pain, adversity, and continually moving forward, Amy has worked through it all with strength and grace.Perseverance: “Even when I survived, I think, it made me have to really dig deep and figure out, okay, there's certain things I can change, there's certain things I can't, so I decided to really focus on the things that I could change, I decided to focus on what I could do.”Hope: “I still wanted to live a great life. I was still me, I very much so still felt like me. I'm the same person, the same drive, the same aspirations. I wanted to travel, I wanted to snowboard all over the world. I still wanted to do all of that. I just now had to figure out how, and I had to get creative to find a way.”Positivity: “It didn't feel good to have people feel sorry for me. And so I knew that I didn't want to feel sorry for myself. I thought ‘that's a bad spot to be in.’ ”Mindset: “One major thing that I did was I got really good at compartmentalizing because I was dealing with losing my legs, losing my kidney function and needing a kidney transplant and then losing part of my hearing as well, all at the same time.”Focus: “When I think of all my accomplishments, the things that I've done in my life, I get very hyper-focused. I kind of shut everything else away and just focus on what needs to be taken care of.”Healing: “I started this whole new journey that I'm on of fighting to get back. … I realize the doctors have done what they can. Now it's up to my body to do the rest and how can I support my body to not just heal but literally do more than that, right? Like grow new connections, create new pathways.”Don’t miss my hacking recommendation list for Amy in the episode show notes or my IG Live with Amy; it’s up now on the Bulletproof Radio YouTube channel.Enjoy the show!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Apr 20201h 16min

In this episode of Bulletproof Radio, my guest is a leading voice for change in social and corporate policy to bring greater harmony between work and the rest of life—especially for parents.Stewart Friedman currently is an organizational psychologist and professor of management practice at the Wharton School. He’s an award-winning professor and bestselling author who founded Wharton’s Leadership Program and its Work/Life Integration Project nearly 30 years ago. Flexibility is a big part of that integration, and the timing couldn’t be better. The realities of working at home—with kids—is settling in for many familiesA simple acknowledgement of “I'm a human being beyond the work exchange that we're doing right now, and so are you, so let's deal with that,” is necessary, Stew says. “We're being forced to do that now and I think that that's helping everybody. It does require, as I say, some adjustment and flexibility, but I think if you negotiate it just a bit up front it makes everything a lot easier.”In his new book, “Parents Who Lead: The Leadership Approach You Need to Parent with Purpose, Fuel Your Career, and Create a Richer Life,” parents learn how to apply leadership principles to their parenting style and drive values in ways that benefits the whole family. In our discussion, Stew gives great tips on how parents can uplevel their parenting game, especially during this time when coronavirus is forcing so many of you to make changes to your home and family life.“Parents who lead are those who have a sense of what matters to them and they're figuring out, just as we all are, each day a new way to take a step in a direction that's closer and closer to that world that they see as a better tomorrow for them and the people that they care about,” Stew says.Enjoy the show! And get more resources at Dave.Asprey/podcasts. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

8 Apr 202052min

In this episode of Bulletproof Radio, my guest is Jamie Metzl, a leading futurist, geopolitical expert, science fiction novelist, media commentator and a senior fellow at the Atlantic Council. He served in the White House, State Department, and United Nations.In 2019, he was appointed to the World Health Organization’s (WHO) expert advisory committee on developing global standards for the governance and oversight of human genome editing. Jamie’s work with the WHO and his background in international relations gives him a unique perspective on the coronavirus. It another great connection, his newest book “Hacking Darwin: Genetic Engineering and the Future of Humanity” leads us right into a discussion about genetic engineering to help fight viruses. “We like to imagine ourselves in harmony with nature, but we're at war with nature,” Jamie says. There are reasons to both fear and be excited about the possiblities of genetic engineering.Jamie also provides advisory services to governments, businesses, and institutions about the best ways to understand, predict, and prepare for revolutionary and converging technological, social, and geopolitical change. The coronavirus pandemic set in motion an evolving series of crises around the world—from governance to health to economic and, finally, to political.“We have a huge fight ahead of us,” Jamie says. “The world on the other side is going to be very different from what it is going in, but now's the time we need to be thinking about what we want that world to look like, and making sure that it's a world that reflects our best values.” Enjoy the show! And get more resources at Dave.Asprey/podcasts. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Apr 202043min

This episode of Bulletproof Radio is a special in-person podcast at the Milken Global Conference in Abu Dhabi with Deepak Chopra.Deepak Chopra, M.D., FACP, is a world-renowned pioneer in integrative medicine and personal transformation. TIMEmagazine described him as “one of the top 100 heroes and icons of the century.” He’s been exploring the intersection of science and spirituality for decades. Immersed in the study and practice of meditation, Ayurveda and mind-body-soul connection, his teachings have greatly influenced our modern understanding of the self. His long scholarship and research of human consciousness has furthered our understanding of what’s real and what’s possible.“In terms of human potential, metareality isn’t outer space but the pure, unbounded consciousness that lies at the source of the mind,” he says in our interview.“Consciousness is the knowing element in every experience, whether it's perception, or mental, or emotional, or imagination,” Deepak continues. “Any sensation, any perception, any feeling, any thought is constantly bubbling out of consciousness. And we have constructed a physical universe out of it, which is brilliant, actually, because, in a way, humans are representing the infinite as this experience.”We discuss what it means to be “beyond human” based on Deepak’s 90th book: Metahuman: Unleashing Your Infinite Potential. You’ll learn how to question reality, move past limitations constructed by your mind, and enter a new state of awareness. And when you realize a “reality without limits,” you’ll be able to realize your full human potential.Enjoy the show! And get more resources at Dave.Asprey/podcasts. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Apr 202057min

In this episode of Bulletproof Radio, my guest is known as "the woman who wants to genetically engineer you," and a leading voice for genetic cures.Liz Parrish founded and serves as CEO of BioViva Sciences USA Inc., a bioinformatics company actively working to extend healthy lifespans using gene therapy. It’s looking specifically at how gene therapy works in humans and how regenerative genes work in human bodies. Its partner company, Integrative Health Systems, helps people get access to these technologies today.A strong champion of progress and education for the advancement of gene therapy, Liz firmly supports our right and our ability to hack our own DNA.And she definitely walks her talk: In 2015 she became the first person in the world to take dual gene therapies to treat aging. One of the ways was to use adeno-associated virus, called AAV. “AAV doesn't essentially do what old gene therapy does,” she explains. “So, you don't get sick when you take it, because if you get sick then you're going to not uptake the genes. … And viruses are still the best gene delivery method there is. They get genes into the nucleus.”“Remember, these viruses are modifying you every year,” Liz says. “You get viruses and influenzas and things like that and they all do their little dance. We're just making them do a dance that only up-regulates therapeutic genes.”From increased muscle mass to mitochondria, and from clinical trials to affordability, our conversation about gene therapy takes you into new territory. Listen on to learn more about Liz’s personal experience, her longevity work, and how you can shape your own genes.Enjoy the show! And get more resources at Dave.Asprey/podcasts. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

31 Mar 202059min

In this special episode of Bulletproof Radio, microbiologist and geneticist David Sinclair, Ph.D., gives a thoroughly researched perspective on the coronavirus, plus concrete steps you can take and lifestyle changes you can make to potentially lower your own risk.We cover food, fasting and fitness. A range of supplements. The research behind and benefits of a vaccine, the red tape of regulation, availability of home test kits, and much more. David is a professor in the department of Genetics at Harvard Medical School and founding director of the Paul F. Glenn Center for the Biological Mechanisms of Aging at Harvard. He’s best known for his extensive research on lifespan extension and treatment of diseases for aging. He’s an award-winning researcher whose work on resveratrol, NAD, and reprogramming to reverse aging have been widely hailed as major scientific breakthroughs.“Before this [coronavirus] happened, it was pretty obvious to me as someone who was already working in a company that was detecting viruses that these things were going to attack,” David says.Listen on for an in-depth discussion of recent coronavirus research and the COVID-19 strain that’s making its way around the world. Enjoy the show!Get links, resources and show notes at Dave.Asprey/podcasts.Watch the Instagram live Q&A video of Dave and David Sinclair, Ph.D., on YouTube.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Mar 20201h 1min