1005: David Fajgenbaum | Leveraging AI to Cure Rare Diseases

Randolph Nesse (@randynesse) is the founding director of the Center for Evolution Medicine at Arizona State University and author of Good Reasons for Bad Feelings: Insights from the Frontier of Evolutionary Psychiatry. What We Discuss with Randolph Nesse: What possible purpose do anxiety, depression, and anger serve from an evolutionary standpoint? Why the body's mechanisms for keeping us safe often overreact, and what we can do to get a handle on them when they work a little too well. The evolutionary upsides to worrying about what other people think of us. Why natural selection shapes our behavior toward reproduction rather than health and longevity. Why do women often go for the reckless mate instead of the safe mate -- and why do men stick around at all? And much more... Full show notes and resources can be found here: jordanharbinger.com/377 Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14 Juli 20201h 13min

Because of the economic downturn, you're forced to lay off someone who gave up a lot to accept the job on your recommendation. How do you fire someone you care about? We'll tackle this and more here on Feedback Friday! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: jordanharbinger.com/376 On This Week's Feedback Friday, We Discuss: Because of the economic downturn, you're forced to lay off someone who gave up a lot to accept the job on your recommendation. How do you fire someone you care about? How should you approach handshakes and face masks for an onsite job interview during the pandemic without seeming unfriendly, strange, or paranoid (or reckless or ignorant)? You want to make your voice heard, but how do you overcome the fear of being exposed, on display, and held to old opinions or snapshots of who you were at a certain period when it's a barrier to your growth? Now sober, you burned a lot of bridges when you weren't. While doing an inventory of your network, should you reach out and apologize to people you wronged, and if you didn't wrong them, how much of a connection do you need to just reach out and be personal? Your gullible brother got out of an MLM scam only to get wrapped up in a currency exchange "company" that operates in a similar manner. How can you help him see the error of his ways without risking his tendency to dig in deeper? As Benjamin Hardy might say: what's next for Future Jordan? Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Gabriel on Twitter at @GabeMizrahi. And if you want to keep in touch with former co-host and JHS family Jason, find him on Twitter at @jpdef and Instagram at @JPD, and check out his other show: Grumpy Old Geeks. Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course!  Like...See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Juli 202048min

Bob Sutton (@work_matters) is a Stanford Business School professor and author of New York Times bestseller The No Asshole Rule and, most recently, The Asshole Survival Guide: How to Deal with People Who Treat You Like Dirt. What We Discuss with Bob Sutton: What is an a-hole, and why do they seem to be everywhere? Why a-holes do not finish first. What to do if you’re forced to work with an a-hole. How to spot the red flags that help you avoid dealing with a-holes in the first place — or know when it’s time to quit the a-holes who are already in your life. How to tell if maybe you’re the a-hole. And much more... Full show notes and resources can be found here: jordanharbinger.com/375 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Juli 202049min

Kelly McGonigal (@kellymcgonigal) is a research psychologist, a lecturer at Stanford University, and an award-winning science writer. She is the author of The Joy of Movement, The Willpower Instinct, and The Upside of Stress. What We Discuss with Kelly McGonigal: How much does the way you think about stress affect your health? Contrary to what medical professionals have been telling you for years, can there really be such a thing as good stress? Why trying to shame someone out of a harmful coping mechanism (overeating, smoking, etc.) can generate the very stress that prompts reliance on that mechanism. How anxiety, pangs of loneliness, and other indications of stress can be seen as calls to action instead of triggers for inappropriate responses. How do genetics play into your relationship with stress? And much more... Full show notes and resources can be found here: jordanharbinger.com/374 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Juli 20201h 24min

Your wife refuses to stand up to her mother about her failing health, instead leaving it up to you to hound her about blood sugar levels, smoking, etc. How can you get your wife more involved in your mother-in-law's health? We'll tackle this and much more here on Feedback Friday! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: jordanharbinger.com/373 On This Week's Feedback Friday, We Discuss: Some food for thought from Ryan Holiday's The Daily Dad newsletter. Your wife refuses to stand up to her mother about her failing health, instead leaving it up to you to hound her about blood sugar levels, smoking, etc. How can you get your wife more involved in your mother-in-law's health? You excel at your job and the rate of upward mobility has been excellent, but you're experiencing burnout. At the point of desperation and without clear direction, what can you do to find a healthy balance? You need an external opinion on how to communicate with a good friend of yours who’s in the middle of a massive manic episode. Here's what we suggest. You're a 70-year-old great aunt, and your grand nephew who just graduated from high school is coming to visit you for a week. What can you do to make it memorable and useful to his development as a young man? Feedback from essays you've written indicates your writing can change lives, but you've promised yourself to focus on a side hustle to eventually expand into a business. So which route should you take: the path of passion or the path of profitability? Recommendation of the Week: Lenox Hill Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Gabriel on Twitter at @GabeMizrahi. And if you want to keep in touch with former co-host and JHS family Jason, find him on Twitter at @jpdef and Instagram at @JPD, and check out his other show:  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Juli 202040min

Bob Saget (@bobsaget) is a comedian, actor, director, host of the Bob Saget's Here For You podcast, and author of Dirty Daddy: The Chronicles of a Family Man Turned Filthy Comedian. What we discuss with Bob Saget: The shared age at which Bob Saget and Richard Pryor knew they were funny. How Bob's sense of humor developed as a mechanism to avoid pain. Why Bob has reinvented himself repeatedly over the course of his career -- from the wholesome family man he portrayed on Full House to the dirty lecher he played on Entourage (and all points between). The big breaks that can come from life's worst disappointments. Bob's proven remedy for dealing with the haters (and we all have haters). And much more... Full show notes and resources can be found here: jordanharbinger.com/372 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Juli 20201h 2min

Maria Konnikova (@mkonnikova) is a regular contributing writer for The New Yorker, a bestselling author, and an international poker champion -- a title she earned while researching her latest book, The Biggest Bluff: How I Learned to Pay Attention, Master Myself, and Win. What We Discuss with Maria Konnikova: How Maria went from being someone who had no interest in poker to raking in big bucks as an international poker champion. How people make decisions and what poker can tell us about reading human motivation. How to spot real physical tells at the poker table (and real life). How we can control and prevent emotional thinking (aka "going on tilt"). Why, in poker as in life, triumph is your foe, and disaster is where you learn. And much more... Full show notes and resources can be found here: jordanharbinger.com/371 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

30 Juni 20201h 24min

Your father already had another family when he decided to have an affair with your mom (which resulted in you). Now that you're 18, is it right for you to still be kept a secret from this other family? We'll tackle this and more here on Feedback Friday! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: jordanharbinger.com/370 On this week's Feedback Friday: If you're feeling unlucky lately, see if you're controlling these three drivers for results. Your father already had another family when he decided to have an affair with your mom (which resulted in you). Now that you're 18, is it right for you to still be kept a secret from this other family? You've made some headway in life, but your social circle has not. As a result, your lack of relatable friendships makes you feel antisocial. Where do you begin the quest for a new social circle? Looking for a job while sheltering in place is a bummer. How can you: a) politely turn away leads you think aren't a good fit out of respect for your old boss who's passing them your way, and b) avoid being the awkward newcomer on Zoom who doesn't know anyone in real life if you do land a new job? How can you tell the difference between a legitimate, positively influential mastermind group and a scammy, fake guru-style mastermind group as we addressed recently in episode 368? New at your job, how should you go about failure when it could jeopardize how others think of you? You want to acknowledge your mistakes without losing the trust of your coworkers and higher-ups. Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Gabriel on Twitter at @GabeMizrahi. And if you want to keep in touch with former co-host and JHS family Jason, find him on Twitter at @jpdef and Instagram at @JPD, and check out his other show:  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Juni 202043min