Effect of therapeutic drug monitoring-based dose optimisation of piperacillin/tazobactam in sepsis patients
ESICM Talk2 Mars 2022

Effect of therapeutic drug monitoring-based dose optimisation of piperacillin/tazobactam in sepsis patients

Growing evidence suggests that insufficient antibiotic exposure (defined as failure to achieve the pharmacokinetic/pharmacodynamic (PK/PD) target to kill or inhibit the growth of a pathogen) is associated with worse clinical outcomes in sepsis patients.

Moreover, up to 50% of critically ill patients receiving a β-lactam antibiotic with regimens based on manufacturers' recommendations fail to reach the target.

Therapeutic drug monitoring (TDM)-guided therapy has been proposed as a strategy to further optimise the achievement of the PK/PD target of β-lactam antibiotics. However, there are no data on whether piperacillin/tazobactam TDM can improve clinical outcomes.

In this context, a large RCT was performed to investigate whether TDM-based dose optimisation versus fixed dosing could improve clinical outcomes in patients with sepsis treated with piperacillin/tazobactam as a continuous infusion.

Dr Hagel shares with us the results of this study published in the ICM Journal.

Original study:

Hagel S et al. Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial. Intensive Care Med. 2022 Mar;48(3):311-321. doi: 10.1007/s00134-021-06609-6

Speakers

Stefan HAGEL. Assistant medical director and consultant at the Institute for Infectious Diseases and Infection Control and Center for Sepsis Control and Care at the Jena University Hospital (DE).

Laura BORGSTEDT. Department of Anesthesiology, Klinikum rechts der Isar, Technical University of Munich, Munich (DE).

Avsnitt(93)

Bullets in haemodynamics

Bullets in haemodynamics

The haemodynamic instability most patients present in the ICU may lead to organ dysfunction, deterioration into multi-organ failure, and eventually death. Proper medical management is essential to pre...

8 Juni 202239min

The brain in paediatric critical care

The brain in paediatric critical care

The practice of neurocritical care for children with injured or vulnerable brains entails clinical assessment, a range of monitoring methods within the paediatric intensive care unit (PICU), and the f...

1 Juni 202226min

The role of acute hypercapnia on mortality and short-term physiology in patients mechanically ventilated for ARDS

The role of acute hypercapnia on mortality and short-term physiology in patients mechanically ventilated for ARDS

Recent evidence suggests that acute hypercapnia could have harmful physiological and clinical effects in patients with ARDS, particularly impacting the haemodynamic system. A review and meta-analysis ...

25 Maj 202211min

Sepsis hospitalisation and risk of subsequent cardiovascular events in adults

Sepsis hospitalisation and risk of subsequent cardiovascular events in adults

Sepsis refers to a dysregulated response to infection-causing end-organ dysfunction. It is associated with short-term risks such as shock and in-hospital death. Meanwhile, long-term consequences among...

13 Apr 202215min

Prophylactic melatonin for delirium in intensive care (Pro-MEDIC)

Prophylactic melatonin for delirium in intensive care (Pro-MEDIC)

Delirium is a condition of acute organic brain dysfunction with fluctuating disturbances of attention and cognition, and its prevalence in intensive care units (ICUs) is recorded as high as 80%.Deliri...

6 Apr 202213min

Role of pre-clinical experimentation in intensive care: from ethical to clinical practice

Role of pre-clinical experimentation in intensive care: from ethical to clinical practice

Preclinical studies precede most clinical trials. They help identify criteria for evaluating human safety, including signs and symptoms that should be monitored closely during early clinical trials.Th...

23 Mars 202232min

Mental health symptoms in family members of COVID-19 ICU survivors

Mental health symptoms in family members of COVID-19 ICU survivors

The prevalence of long-term mental health symptoms in the family members of COVID-19 ICU survivors is unknown and may differ from the prevalence rate in the family members of non-COVID-19 ICU survivor...

16 Mars 202215min

ERC-ESICM guidelines on temperature control after cardiac arrest in adults

ERC-ESICM guidelines on temperature control after cardiac arrest in adults

The aim of the ERC-ESICM guidelines on temperature control after cardiac arrest in adults is to provide evidence-based guidance in adults who are comatose after resuscitation from either in-hospital o...

9 Mars 202215min

Populärt inom Business & ekonomi

framgangspodden
varvet
rss-jossan-nina
rss-svart-marknad
svd-tech-brief
rss-borsens-finest
badfluence
uppgang-och-fall
avanzapodden
bathina-en-podcast
fill-or-kill
rss-inga-dumma-fragor-om-pengar
24fragor
lastbilspodden
rss-dagen-med-di
kapitalet-en-podd-om-ekonomi
tabberaset
rss-veckans-trade
rss-kort-lang-analyspodden-fran-di
borsmorgon