Permissive azotemia during AKI enables more rapid renal recovery and less renal fibrosis
Preclinical models of acute kidney injury (AKI) consistently demonstrate that a uremic milieu enhances renal recovery and decreases kidney fibrosis. Reduced renal clearance has the surprising and count...
17 Maj 202343min
How to manage coagulopathies in critically ill patients
Coagulopathy is a severe and frequent complication in critically ill patients, for which the pathogenesis and presentation may be variable depending on the underlying disease. Therefore, a review has ...
10 Maj 202320min
End of Life Care concepts in intensive care
End-of-life care is an approach to a terminally ill patient that shifts the focus of care to symptom control, comfort, dignity, quality of life, and quality of dying rather than treatments aimed at cu...
3 Maj 202330min
Machine-learning-derived sepsis bundle of care
The Surviving Sepsis Campaign (SSC) produces and regularly updates guidelines for managing patients with sepsis and septic shock. However, deviation from guidelines is frequently observed in the inten...
22 Mars 202326min
How to use biomarkers of infection or sepsis at the bedside
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. In this context, biomarkers could be considered indicators of either infection or dysregulated host ...
15 Mars 202324min
MIPD of beta-lactam antibiotics and ciprofloxacin in critically ill patients
Individualising drug dosing using model-informed precision dosing (MIPD) of beta-lactam antibiotics and ciprofloxacin has been proposed as an alternative to standard dosing to optimise antibiotic effi...
25 Jan 202317min
Management of severe bronchiolitis in infants <12 months old admitted to paediatric ICU
Bronchiolitis is a common lung infection in young children and infants. Approximately one-tenth of the affected children are admitted, and between 2 and 6% of them present a severe form and are referr...
18 Jan 202313min
Clustering analysis of geriatric and acute characteristics in very old patients on ICU admission
The outcome of very old patients admitted to the intensive care unit (ICU) is determined by both the severity of the acute condition and the age-related decline of resilience to stress. However, that ...
11 Jan 202312min
