256. How Big Pharma Turned Disease Into a Trillion-Dollar Industry w/ Brigham Bhuler

Benjamin Bikman earned his PhD in Bioenergetics and was a postdoctoral fellow with the Duke-National University of Singapore studying metabolic disorders. Currently, his professional focus as a scientist and professor (Brigham Young University) is to better understand the origins and consequences of metabolic disorders, including obesity and diabetes, with a particular emphasis on the role of insulin. He frequently publishes his research in peer-reviewed journals and presents at international science and public meetings.   Time Stamps   0:11:14 Podcast Begins 0:11:54 Ben's Background 0:17:53 The root of chronic disease 0:25:38 All about insulin 0:31:14 Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification https://www.semanticscholar.org/paper/Regulation-of-free-fatty-acid-metabolism-by-insulin-Campbell-Carlson/9be324b8af9ced5a8b7e1902257e3fb9308b4db1 0:31:51 Insulin stops lipolisis 0:34:35 Insulin's affect on the liver 0:40:10 Insulin and muscle cells 0:43:20 Why you want to increase protein as you age 0:48:47 Low Protein Intake is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988204/#:~:text=Low%20Protein%20Intake%20is%20Associated,Younger%20but%20Not%20Older%20Population&text=Cell%20Metab.,Author%20manuscript. 0:51:00 Animal-based diets optimize muscle protein sythesis 0:55:12 Industrial Seed oils have a fantastic publicist 0:58:05 Do carbs drive metabolic dysfunction? 1:07:07 Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man https://link.springer.com/article/10.1007/BF00400466 1:07:42 How linoleic acid drives metabolic dysfunction 1:09:32 How linoleic acid drives metabolic dysfunction.  1:11:47 Low serum insulin in traditiona

8 Sep 20202h 14min

With levels of linoleic acid consistent with our evolutionary past, omega-3s aren't an issue if you are eating nose to tail! I also talk about CLA, how linoleic acid makes you fat. Check us out at www.heartandsoil.co  and @heartandsoilsupplements on instagram to get nose to tail nutrition!

4 Sep 202027min

Elle Russ  returns for her second show! She is a bestselling author, TV/Film writer, and seasoned life coach. She is the author of Confident As Fu*k and The Paleo Thyroid Solution – a book which has helped thousands of people around the world reclaim their health. Elle is also the show host for NYT’s bestselling author Mark Sisson’s popular Primal Blueprint Podcast.  Time Stamps:  0:10:44 Beginning of Podcast with Elle Russ 0:12:14 Elle's Story 0:13:50 The outdated "expertise" of thyroid doctors 0:16:17 Understanding the thyroid & reverse T3 https://sproutshealth.com/the-role-of-reverse-t3-in-thyroid-function-part-1/#:~:text=Reverse%20T3%20is%20like%20a,still%20may%20experience%20hypothyroid%20symptoms. 0:24:44 Hypothyroidism Chart https://www.straighthealthcare.com/hypothyroidism.html 0:27:26 Chemistry of Thyroid Hormones http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/thyroid/chem.html 0:29:16 Thyroid Hormone Synthesis http://pathwaymedicine.org/thyroid-hormone-synthesis 0:30:30 Proper testing for Hashimoto's thyroiditis 0:31:03 Leveraging Carnivore for Hashimoto's 0:31:52 Why test for Reverse T3? 0:34:40 Get a comprehensive thyroid panel 0:37:06 Iron's role in thyroid hormone function 0:39:29 The interconnectedness of organ systems 0:41:56 Treating the whole body 0:43:16 Eat your spleen! 0:45:34 Everything works together 0:48:52 Should we sweat high iron levels? 0:50:29 Improve your orgasm quality 0:51:40

31 Aug 20201h 50min

Heart & Soil is now a reality! This is my passion company founded to help a few million more people reclaim their ancestral birthright to radical health through nose to tail nutrition. We are making grass fed, grass finished desiccated organ capsules from regenerative farms in New Zealand. Check us out at: www.heartandsoilsupplements.com    Controversial thoughts! Two solid studies which show the dangers of linoleic acid!

28 Aug 202020min

Heart & Soil is now a reality! This is my passion company founded to help a few million more people reclaim their ancestral birthright to radical health through nose to tail nutrition. We are making grass fed, grass finished desiccated organ capsules from regenerative farms in New Zealand. Check us out at: www.heartandsoilsupplements.com    The second edition of The Carnivore Code is now live in print, ebook, and audiobook formats!  www.Thecarnivorecodebook.com to order!    Lucy’s Bio: Lucy Mailing, PhD received her Bachelor’s in Biology from Kalamazoo College and her PhD in Nutritional Sciences from the University of Illinois, where her dissertation research focused on the effects of diet and exercise on the gut microbiome in states of health and disease. Lucy has authored several peer-reviewed journal articles related to the microbiome and health and was named an Emerging Leader in Nutritional Sciences by the American Society for Nutrition in 2017. Lucy has also served as staff research associate for the Kresser Institute for Functional and Evolutionary Medicine since 2015. Lucy is the founder and sole author of NextGen Medicine, a site dedicated to evidence-based articles about the microbiome, gut and skin health, and nutrition. She is regularly invited to speak on gut health around the country and has been recognized as one of the most trusted experts in the integrative health space. Lucy plans to continue her academic training and begin a postdoc in 2020 after a gap year dedicated to NextGen Medicine.   Time Stamps:   0:12:07  Podcast starts   0:12:41  Lucy Mailing's story   0:14:13  How exercise affects the microbiome   0:15:34  Lucy breaks down the microbiome   0:25:15  Mapping your biodiversity   0:28:56  Alpha diversity vs Beta diversity   0:31:08  Medication's effect on biodiversity   0:32:38  Seasonal diets improve biodiversity   0:37:21. Fiber! Do we need it?   0:43:53  Diet rapidly and reproducibly alters the human gut microbiome   0:46:02  How Lucy healed her eczema   0:50:01  Selecting the least toxic plant foods   0:52:19<span class= "gmail-Apple-converted-

24 Aug 20201h 35min

Heart & Soil is now a reality! This is my passion company founded to help a few million more people reclaim their ancestral birthright to radical health through nose to tail nutrition. We are making grass fed, grass finished desiccated organ capsules from regenerative farms in New Zealand. Check us out at: www.heartandsoilsupplements.com    The second edition of The Carnivore Code is now live in print, ebook, and audiobook formats!  www.Thecarnivorecodebook.com to order!    Time Stamps:   0:12:03 Michael Ruscio's Background 0:14:38 Divergence from dogmatism 0:19:55 Start with the gut 0:24:28 Food reactivity latency 0:26:28 Healing the gut: the algorithmic approach 0:30:11 Stopping or reducing dietary fiber intake reduces constipation and its associated symptoms https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435786/ 0:30:14 Elimination protocols 0:33:31 The healing power of fiber-free diets 0:44:05 How to feed your microbiota 0:46:59 Diet rapidly and reproducibly alters the human gut microbiome https://www.nature.com/articles/nature12820 0:47:41 Non-fiber solutions for the microbiome 0:52:35 Targeting long-term gut health through a 360 approach 0:56:22 Is the Carnivore diet sustainable for long-term adherence? 0:58:33 The spectrum of plant food toxicity 1:02:19 Leveraging the power of probiotics 1:19:12 Michael Ruscio's radical body sliding Heart & Soil: www.heartandsoilsupplements.com  @heartandsoilsupplements on Instagram   Nutrisense (Continuous Glucose Monitor- CGM): www.Nutrisense.io, use the code CarnivoreMD for 20$ off.    BluBlox: www.blublox.com use the code CarnivoreMD for 15% off your order   White Oak

18 Aug 20201h 25min

Heart & Soil is now a reality! This is my passion company founded to help a few million more people reclaim their ancestral birthright to radical health through nose to tail nutrition. We are making grass fed, grass finished desiccated organ capsules from regenerative farms in New Zealand. Check us out at: www.heartandsoilsupplements.com    The second edition of The Carnivore Code is now live in print, ebook, and audiobook formats!  www.Thecarnivorecodebook.com to order!  Heart & Soil: www.heartandsoilsupplements.com

14 Aug 202027min

Heart & Soil is now a reality! This is my passion company founded to help a few million more people reclaim their ancestral birthright to radical health through nose to tail nutrition. We are making grass fed, grass finished desiccated organ capsules from regenerative farms in New Zealand. Check us out at: www.heartandsoilsupplements.com    The second edition of The Carnivore Code is now live in print, ebook, and audiobook formats!  www.Thecarnivorecodebook.com to order!  Dr. Vincent M. Pedre, Medical Director of Pedre Integrative Health and President of Dr. Pedre Wellness, is a Board-Certified Internist in private practice in New York City since 2004. His philosophy and practices are a blend of both Western and Eastern medical traditions. He is a Clinical Instructor in Medicine at the Mount Sinai School of Medicine, as well as certified in yoga and Medical Acupuncture. Time Stamps:   0:10:46 Dr. Vincent Pedre’s background  0:13:17 The vastness of our microbiomes  0:18:31The effect of GMOs on the microbiome of the soil 0:23:15 Reversing climate change through healing the soil 0:28:41 Healing the microbiome through reconnecting with nature.  0:33:41 Saving the planet through creating ecosystems  0:34:32 Observations of the gut microbiome of the Hadza 0:39:24 Fiber does not increase microbiome diversity  0:40:44 Diet rapidly and reproducibly alters the human gut microbiome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957428/ 0:43:35 Plant-animal subsistence ratios and macronutrient energy estimations in worldwide hunter-gatherer diets https://academic.oup.com/ajcn/article/71/3/682/4729121 0:45:23 The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy https://www.nature.com/articles/s41522-018-0073-2?fbclid=IwAR1q7BKu4IN1-9g1E7PGBpwfvzVPu7Xe2g4omFEMR7B8HfBMKrd2kIHMCVw 0:45:50 Reduced

10 Aug 20201h 34min