Ep. 142: Papers of the Month: Mismatch Repair & DNA Expansion in Huntington’s Disease

Ep. 142: Papers of the Month: Mismatch Repair & DNA Expansion in Huntington’s Disease

Moderator: Jean-Marc Burgunder (Guemligen, Switzerland)Guest: Sandrine Humbert (Paris, France)In this week's episode, Burgunder and Humbert discuss the intriguing phenomenon of somatic expansion—the further increase of CAG repeat numbers in the gene involved in Huntington’s disease, particularly in the striatum. They explore the molecular mechanisms behind this process, as addressed in two recent research papers.Please find here the papers discussed in this episode: Long somatic DNA-repeat expansion drives neurodegeneration in Huntington’s diseaseand Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD mice.eanCampus access for Associate Members: If you are a member of a National Neurological Society in Europe, you are most likely aleady an Associate Member of the EAN and have an account for the eanCampus. If you have provided your email address to your National Neurological Society, it should already be in our database. Here is how you can access the eanCampus as an Associate Member:1. Enter the eanCampus2. Click on the Log In Button3. Log in with your MyEAN credentials and make use of the ‘forgot password’-functionality if necessaryIf you have trouble logging in, please get in contact with our Membership department (membership@ean.org) to cross-check if you are listed as an Associate Member to get access to eanCampus.

Avsnitt(189)

Ep. 141: Sodium Valproate in Men

Ep. 141: Sodium Valproate in Men

EAN moderator: Barbara Tettenborn (St. Gallen, Switzerland) Guest: Tony Marson (Liverpool, UK) In this special episode, Tettenborn and Marson discuss sodium valproate treatment for epilepsy, focusing...

30 Mars 202518min

Ep. 140: Transition from Childhood to Adulthood​

Ep. 140: Transition from Childhood to Adulthood​

Moderator: Gudrun Gröppel​ (Linz, Austria) Guests: Dana Craiu​ (Bucharest, Romania), Thomas Berger​ (Vienna, Austria) This episode explores the challenges and solutions in transitioning young neurol...

23 Mars 202520min

Ep. 139: Supporting Early Brain Development

Ep. 139: Supporting Early Brain Development

Moderator: Leena Haataja (Helsinki, Finland) Guests: Silja Kosola (Helsinki, Finland), Liisa Lehtonen (Turku, Finland) In the third March episode Haataja, Kosola and Lehtonen focus on evidence-based...

16 Mars 202524min

Ep. 138: The Brain Health Mission Roadmap

Ep. 138: The Brain Health Mission Roadmap

Moderator: Elena Moro (Grenoble, France) Guest: Paul Boon​ (Gent, Belgium) This special episode of eanCast explores the Brain Health Roadmap Paper initiated by the European Academy of Neurology, high...

9 Mars 202518min

Ep. 137: New Horizons on Treatment Choices of Rare Disorders

Ep. 137: New Horizons on Treatment Choices of Rare Disorders

Moderator: Justyna Paprocka (Katowice, Poland) Guests: Laurent Servais (Oxford, UK), Michelangelo Mancuso (Pisa, Italy) In this first March episode, Paprocka, Mancuso, and Servais explore groundbrea...

2 Mars 202525min

Ep. 136: Susac Syndrome

Ep. 136: Susac Syndrome

Moderator: Andreu Vilaseca (Rochester, USA) Guest: Barbara Willekens (Edegem, Belgium) and Ilka Kleffner (Bochum, Germany) For the last February episode join Vilaseca, Willekens and Kleffner as they...

23 Feb 202534min

Ep. 135: Cannabis based medicine in neurology

Ep. 135: Cannabis based medicine in neurology

Moderator: Yıldız Değirmenci (Istanbul, Türkiye) Guest: Natalia Szejko (Warsaw, Poland) In this episode Yıldız Değirmenci interviews Natalia Szejko about the controversial topic of cannabis-based med...

16 Feb 202526min

Ep. 134: Recognizing autoinflammatory syndromes as a neurologist

Ep. 134: Recognizing autoinflammatory syndromes as a neurologist

Moderator: João Moura (Porto, Portugal) Guest: Jeroen Kerstens (Edegem, Belgium) In this episode João Moura and Jeroen Kerstens focus on autoinflammatory syndromes. They discuss how to diagnose them...

9 Feb 202520min

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