Part 32 - Stephan Guyenet, PhD on the Brain Controlling Body Fatness, Your Food Environment, and Low Carb Controversy

Part 32 - Stephan Guyenet, PhD on the Brain Controlling Body Fatness, Your Food Environment, and Low Carb Controversy

Today we're talking to Stephan Guyenet who has a degree in biochemistry and a PhD in neuroscience. He's spent over 12 years in the neuroscience research world studying neurodegenerative disease and the neuroscience of body fatness. He wrote a great book called The Hungry Brain, speaks at conferences, is a Senior Fellow at GiveWell and scientific reviewer for the Examine.com Research Digest.

He is definitely not a low carb person which is why I had him on. He has a lot of great ideas and is a great mind in the space of nutrition. It was very interesting to hear him talk about all the great benefits he did see when he ate a low carb diet 11 years ago. Make sure to listen until the end when he talks about this.

He has some problems with certain people and aspects of the low carb community and is going on Joe Rogan's podcast soon to debate Gary Taubes on his views of the Carbohydrate Insulin theory of obesity and sugar being uniquely toxic

We had some disagreement on the recommended daily allowance of nutrients - he thinks what's recommended is all you need and getting more than that is pointless. I think this is wrong. I think he's basing it on studies of worthless, non-bioavailable vitamin C pills that in excess do nothing. So in that - I agree. I don't think there's any benefit to popping a bunch of these and think we're going to cure a cold. I do know that our ancestors got estimates of 10-20 times the amount of nutrients we get today, so there's a lot more to this discussion that we didn't have time to get into.

We also disagreed on fiber which led to some carnivore talk. He got some things wrong about the member of the Grateful Dead who was a carnivore. He said he died at a young age of a heart attack. I looked into it and it turns out he was carnivore for 48 years and was in excellent health and died in a car accident at 72.

He also says we don't have longterm studies on the safety of low carb diets at the end. This isn't exactly true and furthermore, we have hundreds of thousands of years of human populations living on low carb diets to prove its safety and efficacy. He additionally mentions the low carb community makes crazy claims that aren't based on science. I'm not sure what he's referring to. Not everything can be measured anyway. If tens of thousands of people report to their doctor they aren't hungry anymore, their energy is stable, their brain is working better, they aren't addicted to sugar, they finally have control of their food intake, etc. then this is some great clinical observations and patient anecdotes that add up to a lot.

I think everyone has their own ideas about things and collects info to support their opinion. It's only natural, and I'm sure I'm doing it to, even though I'm trying not to. Everyone has to be in their camp and collect data and narratives to support their theories. He seemed to do this as you'll see throughout the episode.

I agreed with a lot of his points though, especially that humans didn't evolve to eat based on tracking macros and calories and using an excel spreadsheet to figure out what to eat. He's doing great work and looking at this from a different angle which is important. A lot of interesting stuff here so let's get to it. But first I gotta mention the Food Lies film which is in the last stretch of crowdfunding on Indiegogo. We really need your help to finish it. We have a bunch of cool perks like the Eat Meat T-shirt, the movie poster, bonus features, and more. Find it through FoodLies.org or by clicking through this link in the show notes. I really appreciate it - and now here's Stephan Guyenet.

http://indiegogo.com/projects/food-lies-post

Show Notes

  • I'm obsessed with why we get fat and what to do about it and you've been researching this for a long time
  • Why the brain is the most important place to focus on
  • The brain regulates how much we eat, our food choices, and our exercise
  • There's also non conscious processes the brain regulates that influence caloric expenditure, etc.
  • We also study the human genome to find how that plays a role in body fatness
  • When it comes to body weight, the genes that relate the most are in the brain
  • Nobody wants to overeat, but we end up doing it anyway
  • We need to look at our past to understand why we are wired to seek excess calories
  • Animals and hunter gatherers we've studied follow the Optimum Foraging Theory when they acquire food. It's all about the calories per the amount of effort
  • Because we were eating whole foods from nature, if we got enough calories, we by default we're getting all the vitamins and minerals needed
  • They didn't have white flour, sugar, or refined oils
  • We only have receptors for fat, sugar, salt, and glutamate
  • Apparently those are the nutrients that natural selection cared about most to create reward systems for
  • The Hadza people went mainly for meat, tubers, and honey and didn't go for leafy greens
  • The brain is motivated to pursue calorie containing foods, not vitamins and minerals
  • Combining bliss points make certain foods almost irresistible
  • You need to control your food environment
  • Not only don't have it sitting out so you can see certain foods, don't even have them in the house
  • How do genetics play a role? We know it's way more to do with the type of foods eaten
  • About 70% of people in countries like the US are genetically susceptible to become obese when eating the bad diet that exists there. The remaining percent just aren't as susceptible and can get away with it
  • Energy balance while always be a fact, but there's a lot more to it
  • Eat less, move more may work for some people, but it's not how we evolved. It's not a natural way to regulate body weight
  • You can set up a food environment to allow your body to naturally eat the right amount
  • You'd have to be hungry all the time to continue eating processed foods and try to lose weight
  • His definition and thoughts on nutrient density
  • Questioning the necessity of fiber
  • His views on the carnivore diet - he thinks a big factor is becoming lean and it certainly does that
  • He questions if there's long term chronic disease problems that we don't know about
  • Inuit seek some plant matter
  • Sound engineer from the Grateful Dead who was carnivore for 48 years - Stephan said he died of a heart attack at a young age. Turns out he was super healthy and died of a car accident at 72.
  • His book https://justmeat.co/docs/the-bear.pdf
  • They call him "Bear" https://dangerousminds.net/comments/uncle_johns_ham_the_grateful_deads_all-meat_diet
  • Wikipedia on him: https://en.wikipedia.org/wiki/Owsley_Stanley
  • Stephan agrees with what I always say about going to either end of the extreme with super low carb or super low fat you have great benefits
  • He's going on Joe Rogan's podcast to debate Gary Taubes on his views of the Carbohydrate Insulin theory of obesity and sugar being uniquely toxic
  • What happened with Gary Taubes and Dr. Peter Attia's non profit venture NuSI - the Nutritional Science Initiative?
  • What Stephan got wrong in his blog posts
  • Why he thinks Gary Taubes is wrong and what is the evidence
  • He doesn't like the fact that Gary is calling out scientists
  • Exercise and weight loss
  • The model of obesity he subscribes to is that it's all regulated by the brain
  • Homeostatic regulation - hypothalamus controls body fatness like a thermostat
  • The hormone leptin sends feedback to your brain regarding body fat levels
  • Personal fat threshold, how someone can be skinny on the outside but fat on the inside, people can be obese but metabolically healthy, and insulin as a dam holding back fat in the cells
  • He doesn't think that eating an insulin lowering diet like low carb allows you to lose weight because of the lowered insulin
  • He thinks low carb diets and low fat diets work merely because you're taking away the extreme motivation to overeat the foods, AKA hyperplatability
  • Potato hack
  • Metabolic flexibility
  • He thinks being metabolically inflexible is more a sign of insulin resistance than anything
  • He eats about 50% carb, 18% protein, 32% fat
  • He ate a low carb diet after reading Taubes' book Good Calories, Bad Calories 11 years ago
  • He said it was about the same but one benefit was that he wasn't tied to meal times. Eating high carb he definitely knew when it was time to eat. Easier to fast
  • He was easily doing 24 hour fasts. Now on high carb it's way harder and he experiences brain fog
  • Why are low carb diets so maligned in the mainstream media and medical system?
  • What are his solutions for fixing the nation's health problems?
  • His book The Hungry Brain http://www.stephanguyenet.com/thehungrybrain/
  • His website http://www.stephanguyenet.com
  • His Twitter https://twitter.com/whsource

Preorder the film here: http://indiegogo.com/projects/food-lies-post

Film site: http://FoodLies.org

YouTube: https://www.youtube.com/c/FoodLies

Sapien Movement: http://SapienMovement.com

Follow along:

http://twitter.com/FoodLiesOrg

http://instagram.com/food.lies

http://facebook.com/FoodLiesOrg

Theme music by https://kylewardmusic.com/

Avsnitt(232)

Part 229 -Reviving Regenerative Agriculture with Will Harris

Part 229 -Reviving Regenerative Agriculture with Will Harris

Will Harris is known for his pioneering regenerative agriculture practices. The episode explores Harris's journey from traditional farming to regenerative agriculture, the economic challenges, and the impact on land, community, and ecosystems. Harris shares insights from his experiences, including his transition away from chemical-dependent farming and the development of vertically integrated operations. They discuss the benefits of regenerative practices, the difficulties in marketing and scaling, as well as the broader implications for nutrition and sustainability. Lastly, the episode addresses the sustainability of feeding the world through regenerative practices, emphasizing local community support and the long-term generational benefits. 05:10 Introduction to Will Harris 09:05 Challenges and Evolution in Farming Practices 29:43 The Impact of Erosion on Soil Health 30:09 Scientific Comparison: Monocrop vs. Diverse Ecosystem 30:48 Economic Challenges of Transitioning to Regenerative Farming 31:49 The Rise of Grass-Fed Beef and Market Challenges 33:00 Educating Consumers on Grass-Fed Beef 35:03 The Influence of Propaganda on Food Choices 42:18 The Role of Debt in Farm Management 44:15 Challenges in Poultry Farming 50:31 The Benefits of Regenerative Agriculture 53:31 Feeding the World Sustainably 01:00:20 Reflections on the Future of Regenerative Farming BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

29 Okt 1h 2min

Sapien Podcast- Fiber Myths, Vitamin C Lies, and the Fight for Root-Cause Health with Chris Kruger

Sapien Podcast- Fiber Myths, Vitamin C Lies, and the Fight for Root-Cause Health with Chris Kruger

In this episode of the Sapien Podcast, Chris Kruger returns as co-host with Brian Sanders for a deep dive into nutrition myths, fiber fallacies, and the failures of mainstream dietetics. Together, they expose how official guidelines and academic institutions push confusion for profit while ignoring root-cause solutions. The hosts critique health narratives around fiber, red meat, vitamin C, and weight-loss drugs, while sharing client case studies that reveal the real path to metabolic health. They emphasize the Sapien approach: whole foods, animal-based nutrition, hormone balance, and lifestyle over pills and procedures. SHOW NOTES: 04:00 The Football Analogy: nutritionists misunderstand cause and effect 06:00 Debunking fiber myths and why whole foods matter most 09:00 Case study: reversing lifelong constipation with a low-fiber diet 12:00 Red meat, healthy user bias, and flawed nutrition studies 14:30 Academia, food industry funding, and distorted guidelines 15:30 Carnivore diets and the vitamin C myth 18:00 Beyond "calories in, calories out" 27:00 Defining metabolic syndrome vs. metabolic excellence 30:00 Statins, side effects, and why lifestyle beats prescriptions 32:00 Hormone health as the foundation of motivation and vitality BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

27 Okt 37min

Sapien Podcast- Fitness Wisdom Unplugged

Sapien Podcast- Fitness Wisdom Unplugged

In this episode of the Sapien Podcast, Chris Krueger joins the show as a new co-host along with host Brian Sanders. They introduce the podcast as a fun, unplanned discussion about health, fitness, and hormone optimization. The hosts share personal fitness stories and emphasize the importance of a holistic approach to health, advocating for living naturally and avoiding artificial supplementation like TRT. They critique Brian Johnson's extreme health regimens and promote practical, actionable steps for achieving and maintaining elite health without extensive gym workouts or complex diet plans. SHOW NOTES: 00:00 Introduction to the Sapien Podcast 01:11 Fitness and Hormone Optimization 01:25 Generational Fitness and Relatability 01:43 Chris's Fitness Feats and Midlife Reflections 04:57 The Importance of Staying Active 05:38 Family Dynamics and Health Advice 08:01 The Sapien Lifestyle and Hormone Balance 14:16 Insulin and Metabolic Health 17:31 Raw Milk and Sapien Center Community 18:42 Farmer's Market Raw Milk Prices 20:43 Brian Johnson's Cult-Like Brunch 22:03 The Profit in Food Processing 25:31 Debunking Diet Myths   BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post    Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

22 Okt 35min

Part 228 - Dr. Doug McGuff on High-Intensity Training, Recovery, and the Truth About Nutrition

Part 228 - Dr. Doug McGuff on High-Intensity Training, Recovery, and the Truth About Nutrition

Dr. Doug McGuff is an emergency physician, exercise researcher, and co-author of Body by Science. Known for his pioneering work in high-intensity resistance training, McGuff blends decades of medical practice with deep knowledge of physiology to reveal how short, focused workouts can yield extraordinary health benefits. He also runs training studios in South Carolina that specialize in safe, supervised strength training. In this episode of Peak Human, Brian Sanders and Dr. McGuff dive into why most people misunderstand exercise, the dangers of overtraining, and how nutrition and movement fit together for long-term health. They cover everything from the "12-minute workout" to the role of myokines, why VO₂ max is misunderstood, and how subsidies and processed foods hijacked the human diet. This conversation reframes what it truly means to build strength, resilience, and health for life. Show Notes: 03:00 Dr. McGuff's Background: Emergency Medicine & Strength Training 07:00 Adaptive Resistance Training (ARX) & How It Works 14:00 The Physiology of Strength: Motor Units & True Failure 22:00 The "12-Minute Workout" – Time Efficiency & Maximum Results 25:00 Overtraining, PEDs, and the Myths of Modern Fitness Culture 28:00 Long-Term Damage from Inefficient Training Methods 30:00 You Can't Out-Exercise a Bad Diet 33:00 The Straight Line Between You and the Sun – Whole Food Nutrition 44:00 Debunking the Meat & Gout Myth 48:00 Eat Densely, Move Intensely – Rethinking Fitness Advice 49:00 Cardio Myths, VO₂ Max, and the Zone 2 Obsession 56:00 What Really Correlates With Longevity: Adaptation, Not Numbers BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

24 Sep 1h 14min

Part 227 - Holistic Health, Slow Food, and Lifelong Vitality with Tara Couture

Part 227 - Holistic Health, Slow Food, and Lifelong Vitality with Tara Couture

In this episode of Peak Human, host Brian Sanders welcomes back Tara Couture. Tara, a renowned advocate for the Sapien lifestyle, shares insights into her holistic approach to health, which includes growing her own food and embracing a nutrient-dense diet. The discussion covers various topics, including nutrition, lifestyle factors, nature, hormone optimization for both men and women, and practical tips for adopting this lifestyle even in urban settings. Tara also discusses her new book, 'Radiance of the Ordinary,' which explores the profound rewards of living authentically and nourishing one's body. Brian also highlights the benefits of natural supplements like oyster pills for hormone optimization. A must-listen for anyone interested in sustainable living and holistic health. Show Notes: 00:15 Tara's Lifestyle and Farmstead 00:59 Nutrition and Lifestyle 07:46 Raising Healthy Children 15:36 Cooking and Food Preparation 31:45 Travel and Eating Healthy 35:10 Carbs and Diet Adjustments 36:42 Exploring the Benefits of Carbs 38:00 Introducing Tara's Book: Radiance of the Ordinary 38:46 The Dichotomies of Life and Embracing Mortality 43:33 The Importance of Real Food and Nutrition 48:13 Men's Health and Hormones 57:41 The Simplicity of Whole Foods 01:05:54 The Gift of a Healthy Body BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Tara's Book: https://www.penguinrandomhouse.com/books/798098/radiance-of-the-ordinary-by-tara-couture/ Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

3 Sep 1h 12min

Part 226 - Biohacking and Homesteading: Bridging the Gap with Michael Kummer

Part 226 - Biohacking and Homesteading: Bridging the Gap with Michael Kummer

In this episode, Brian Sanders chats with Michael Kummer about his multifaceted approach to health and wellness, which combines elements of biohacking, fitness, and homesteading. Kummer, a proponent of the 'Sapien' philosophy, emphasizes a diet and lifestyle that closely mimic natural human behaviors. The discussion covers Michael's fitness routine, which involves minimal gym time, his creation of an accessible fitness program, and his unique perspective on the synergy between biohacking and homesteading. They delve into the issue of modern diets, stress, and lifestyle factors impacting health, using Austria as a case study to highlight these trends. Kummer also shares insights into his family's transition to a homesteading lifestyle and offers practical tips for integrating these principles into various lifestyles.   Try the oyster pills! https://nosetotail.org/products/pure-oyster   Show Notes: 02:18 Biohacking vs. Natural Living 04:12 Homesteading and Food Production 08:45 Health Impacts of Modern Lifestyle 12:03 Traditional Food Preparation Techniques 24:41 The Importance of Muscle Mass 28:12 Austrian Lifestyle and Longevity 33:02 Traditional Austrian Diet: Then and Now 33:16 Impact of World War II on Diet and Lifestyle 35:32 Modern Austrian Diet and Health Trends 37:46 Comparing Health Outcomes: Austria vs. USA 45:38 Personal Fat Threshold and Its Implications 51:52 Homesteading and Sustainable Living 54:21 Balancing Modern Life with Traditional Practices 58:21 The Role of Community in Homesteading 01:03:13 Supplements and Whole Foods for Optimal Health   BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post    Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

13 Aug 1h 6min

Part 225 - Unlocking the Secrets of Satiety Per Calorie with Dr. Ted Naiman

Part 225 - Unlocking the Secrets of Satiety Per Calorie with Dr. Ted Naiman

In this episode of Peak Human, host Brian Sanders interviews Dr. Ted Naiman, discussing the concept of satiety per calorie and its implications for diet and health. They dive into the importance of understanding different diet patterns, focusing on high-protein, nutrient-dense foods, and avoiding overly processed foods. The conversation covers the four pillars of satiety per calorie: protein percentage, energy density, fiber content, and hedonics. Dr. Naman also talks about his new book 'Satiety Per Calorie,' which aims to provide a comprehensive understanding of diet and nutrition, helping people make informed food choices to maintain optimal body composition effortlessly. The episode concludes with discussions on the benefits of natural exercise routines and natural supplements for overall health.   Try the oyster pills! https://nosetotail.org/products/pure-oyster   Show notes   00:28 Understanding Diets and Nutrition 01:28 Exercise and Fitness Insights 02:09 Oyster Pills and Testosterone Boost 03:15 Daily Life and Health Philosophy 03:53 Satiety and Nutrient Density 05:38 The PE Diet and Satiety Per Calorie 06:34 Explaining Diet Patterns and Health Outcomes 12:48 Practical Tips for Diet and Exercise 41:09 Understanding Protein Leverage and Obesity 44:07 Can You Get Fat on Protein? 45:47 Nutrient Calories vs. Energy Calories 49:33 The Four Pillars of Satiety Per Calorie 54:42 The Role of Fiber in Satiety 01:01:38 Energy Density and Caloric Intake 01:07:01 The Liver's Role in Metabolism   REGENERATIVE PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post    Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

6 Aug 1h 14min

Part 224- Boosting Health with Oysters: Conversations on Deep Nutrition with Marine Biologist Stephen Kavanagh

Part 224- Boosting Health with Oysters: Conversations on Deep Nutrition with Marine Biologist Stephen Kavanagh

In this episode of Peak Human, host Brian Sanders delves into a comprehensive discussion with marine biologist Stephen Kavanagh, an expert in shellfish and particularly oysters. Brian and Stephen explore the nutritional benefits of oysters, including their historical significance in human evolution and their roles in promoting testosterone, immunity, and overall health. Stephen details his artisanal processes at his facility in Ireland, emphasizing the purity and nutrient density of oysters used in their products. The conversation expands into broader themes of deep nutrition, the slow food movement, and the importance of returning to nature's ratios in our diets. Listeners also receive insights into the issues surrounding processed foods and modern health epidemics like obesity.    Try the oyster pills! https://nosetotail.org/products/pure-oyster   Show Notes: 02:25 The Journey of Oyster Processing and Supplement Manufacturing 06:02 The Aphrodisiac Effect of Oysters 10:00 Nutritional Benefits and Historical Significance of Oysters 14:18 The Importance of Real Food and Avoiding Processed Foods 15:03 Challenges in the Oyster Industry and Food Lies 20:06 The Synergy of Nutrients and Fortified Foods 26:49 Ancient Diets and the Role of Oysters in Human Evolution 28:48 The Nutritional Power of Oysters 29:41 Evolutionary Benefits of Oysters 31:21 Human Connection to Marine Life 32:17 Oysters and Water Quality 33:01 Oyster Pure: Quality and Testing 34:06 Personal Health Benefits of Oyster Supplements 35:29 Challenges in Marketing Oyster Supplements 43:39 The Slow Food Movement   BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post    Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

31 Juli 56min

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