Part 32 - Stephan Guyenet, PhD on the Brain Controlling Body Fatness, Your Food Environment, and Low Carb Controversy
Peak Human - Unbiased Nutrition Info for Optimum Health, Fitness & Living13 Mars 2019

Part 32 - Stephan Guyenet, PhD on the Brain Controlling Body Fatness, Your Food Environment, and Low Carb Controversy

Today we're talking to Stephan Guyenet who has a degree in biochemistry and a PhD in neuroscience. He's spent over 12 years in the neuroscience research world studying neurodegenerative disease and the neuroscience of body fatness. He wrote a great book called The Hungry Brain, speaks at conferences, is a Senior Fellow at GiveWell and scientific reviewer for the Examine.com Research Digest.

He is definitely not a low carb person which is why I had him on. He has a lot of great ideas and is a great mind in the space of nutrition. It was very interesting to hear him talk about all the great benefits he did see when he ate a low carb diet 11 years ago. Make sure to listen until the end when he talks about this.

He has some problems with certain people and aspects of the low carb community and is going on Joe Rogan's podcast soon to debate Gary Taubes on his views of the Carbohydrate Insulin theory of obesity and sugar being uniquely toxic

We had some disagreement on the recommended daily allowance of nutrients - he thinks what's recommended is all you need and getting more than that is pointless. I think this is wrong. I think he's basing it on studies of worthless, non-bioavailable vitamin C pills that in excess do nothing. So in that - I agree. I don't think there's any benefit to popping a bunch of these and think we're going to cure a cold. I do know that our ancestors got estimates of 10-20 times the amount of nutrients we get today, so there's a lot more to this discussion that we didn't have time to get into.

We also disagreed on fiber which led to some carnivore talk. He got some things wrong about the member of the Grateful Dead who was a carnivore. He said he died at a young age of a heart attack. I looked into it and it turns out he was carnivore for 48 years and was in excellent health and died in a car accident at 72.

He also says we don't have longterm studies on the safety of low carb diets at the end. This isn't exactly true and furthermore, we have hundreds of thousands of years of human populations living on low carb diets to prove its safety and efficacy. He additionally mentions the low carb community makes crazy claims that aren't based on science. I'm not sure what he's referring to. Not everything can be measured anyway. If tens of thousands of people report to their doctor they aren't hungry anymore, their energy is stable, their brain is working better, they aren't addicted to sugar, they finally have control of their food intake, etc. then this is some great clinical observations and patient anecdotes that add up to a lot.

I think everyone has their own ideas about things and collects info to support their opinion. It's only natural, and I'm sure I'm doing it to, even though I'm trying not to. Everyone has to be in their camp and collect data and narratives to support their theories. He seemed to do this as you'll see throughout the episode.

I agreed with a lot of his points though, especially that humans didn't evolve to eat based on tracking macros and calories and using an excel spreadsheet to figure out what to eat. He's doing great work and looking at this from a different angle which is important. A lot of interesting stuff here so let's get to it. But first I gotta mention the Food Lies film which is in the last stretch of crowdfunding on Indiegogo. We really need your help to finish it. We have a bunch of cool perks like the Eat Meat T-shirt, the movie poster, bonus features, and more. Find it through FoodLies.org or by clicking through this link in the show notes. I really appreciate it - and now here's Stephan Guyenet.

http://indiegogo.com/projects/food-lies-post

Show Notes

  • I'm obsessed with why we get fat and what to do about it and you've been researching this for a long time
  • Why the brain is the most important place to focus on
  • The brain regulates how much we eat, our food choices, and our exercise
  • There's also non conscious processes the brain regulates that influence caloric expenditure, etc.
  • We also study the human genome to find how that plays a role in body fatness
  • When it comes to body weight, the genes that relate the most are in the brain
  • Nobody wants to overeat, but we end up doing it anyway
  • We need to look at our past to understand why we are wired to seek excess calories
  • Animals and hunter gatherers we've studied follow the Optimum Foraging Theory when they acquire food. It's all about the calories per the amount of effort
  • Because we were eating whole foods from nature, if we got enough calories, we by default we're getting all the vitamins and minerals needed
  • They didn't have white flour, sugar, or refined oils
  • We only have receptors for fat, sugar, salt, and glutamate
  • Apparently those are the nutrients that natural selection cared about most to create reward systems for
  • The Hadza people went mainly for meat, tubers, and honey and didn't go for leafy greens
  • The brain is motivated to pursue calorie containing foods, not vitamins and minerals
  • Combining bliss points make certain foods almost irresistible
  • You need to control your food environment
  • Not only don't have it sitting out so you can see certain foods, don't even have them in the house
  • How do genetics play a role? We know it's way more to do with the type of foods eaten
  • About 70% of people in countries like the US are genetically susceptible to become obese when eating the bad diet that exists there. The remaining percent just aren't as susceptible and can get away with it
  • Energy balance while always be a fact, but there's a lot more to it
  • Eat less, move more may work for some people, but it's not how we evolved. It's not a natural way to regulate body weight
  • You can set up a food environment to allow your body to naturally eat the right amount
  • You'd have to be hungry all the time to continue eating processed foods and try to lose weight
  • His definition and thoughts on nutrient density
  • Questioning the necessity of fiber
  • His views on the carnivore diet - he thinks a big factor is becoming lean and it certainly does that
  • He questions if there's long term chronic disease problems that we don't know about
  • Inuit seek some plant matter
  • Sound engineer from the Grateful Dead who was carnivore for 48 years - Stephan said he died of a heart attack at a young age. Turns out he was super healthy and died of a car accident at 72.
  • His book https://justmeat.co/docs/the-bear.pdf
  • They call him "Bear" https://dangerousminds.net/comments/uncle_johns_ham_the_grateful_deads_all-meat_diet
  • Wikipedia on him: https://en.wikipedia.org/wiki/Owsley_Stanley
  • Stephan agrees with what I always say about going to either end of the extreme with super low carb or super low fat you have great benefits
  • He's going on Joe Rogan's podcast to debate Gary Taubes on his views of the Carbohydrate Insulin theory of obesity and sugar being uniquely toxic
  • What happened with Gary Taubes and Dr. Peter Attia's non profit venture NuSI - the Nutritional Science Initiative?
  • What Stephan got wrong in his blog posts
  • Why he thinks Gary Taubes is wrong and what is the evidence
  • He doesn't like the fact that Gary is calling out scientists
  • Exercise and weight loss
  • The model of obesity he subscribes to is that it's all regulated by the brain
  • Homeostatic regulation - hypothalamus controls body fatness like a thermostat
  • The hormone leptin sends feedback to your brain regarding body fat levels
  • Personal fat threshold, how someone can be skinny on the outside but fat on the inside, people can be obese but metabolically healthy, and insulin as a dam holding back fat in the cells
  • He doesn't think that eating an insulin lowering diet like low carb allows you to lose weight because of the lowered insulin
  • He thinks low carb diets and low fat diets work merely because you're taking away the extreme motivation to overeat the foods, AKA hyperplatability
  • Potato hack
  • Metabolic flexibility
  • He thinks being metabolically inflexible is more a sign of insulin resistance than anything
  • He eats about 50% carb, 18% protein, 32% fat
  • He ate a low carb diet after reading Taubes' book Good Calories, Bad Calories 11 years ago
  • He said it was about the same but one benefit was that he wasn't tied to meal times. Eating high carb he definitely knew when it was time to eat. Easier to fast
  • He was easily doing 24 hour fasts. Now on high carb it's way harder and he experiences brain fog
  • Why are low carb diets so maligned in the mainstream media and medical system?
  • What are his solutions for fixing the nation's health problems?
  • His book The Hungry Brain http://www.stephanguyenet.com/thehungrybrain/
  • His website http://www.stephanguyenet.com
  • His Twitter https://twitter.com/whsource

Preorder the film here: http://indiegogo.com/projects/food-lies-post

Film site: http://FoodLies.org

YouTube: https://www.youtube.com/c/FoodLies

Sapien Movement: http://SapienMovement.com

Follow along:

http://twitter.com/FoodLiesOrg

http://instagram.com/food.lies

http://facebook.com/FoodLiesOrg

Theme music by https://kylewardmusic.com/

Avsnitt(233)

Part 201 - Brad Kearns on Finding the Holy Grail of Diet & Lifestyle

Part 201 - Brad Kearns on Finding the Holy Grail of Diet & Lifestyle

Brad Kearns, 58, is a New York Times bestselling author, Guinness World Record setting professional Speedgolfer, #1 USA-ranked Masters age 55-59 track & field high jumper in 2020, and former national champion and #3 world-ranked professional triathlete. He has written twenty books on diet, health, peak performance, and ancestral living, and is a popular speaker, retreat host, and face of the Primal Blueprint online multimedia educational courses. In 2017, The Keto Reset Diet became a New York Times bestseller, and briefly ranked as the #1 overall bestselling book on amazon.com. Brad also hosts the B.rad podcast BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES: (09:56) We know what's possible. Now let's shoot for optimal. (21:22) Processed foods disrupt our appetite and satiety hormones, prompting us to overeat. (33:02) Injuries are a sign of overdoing it. (40:56) Homo sapiens are built for near-constant everyday movement. (47:38) Always ask "what's optimal" instead of just "what's possible". (59:54) Raw forms of high-toxin natural plant foods is a potentially problematic category of nutrition. (1:08:26) Our main nutritional challenge is energy toxicity. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

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Part 200 - My biggest impact fat loss & health tips

Part 200 - My biggest impact fat loss & health tips

This episode features the synthesis of my learnings after doing 200 episodes over the last 5.5 years with many of the world's top doctors & scientists in the health field. Get 80% of the results with 20% of the effort. I've dedicated my life to learning from the best and distilling things down to actionable insights that make it easy for you to get results. Today my sister interviews me in an episode packed with useful info. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES (10:52) The only nutrition plan you'll be able to stick with for the long-term is the one that you enjoy following, and is both nutrient-dense and complete. (24:58) Food Lies was originally a documentary that turned into a six-part series. (29:43) The Sapien Center can be described as a work-from-home health-focused community that makes the journey to health and longevity sustainable and fun. (36:36) Ancestral health combines how humans traditionally ate with modern medicine to prevent and treat chronic disease. (49:25) The main problem with binge eating dietitians and the fat acceptance movement is that they do not understand that there are differences in food. (57:34) Nutrient calories are not the same as energy calories. (1:07:25) Cholesterol is foundational to hormonal health. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

16 Aug 20231h 20min

Part 199 - Tucker Max on Raising Your Own Food, Providing for Your Family, and the Future of Freedom

Part 199 - Tucker Max on Raising Your Own Food, Providing for Your Family, and the Future of Freedom

Tucker Max has written four New York Times Best Selling books (three that hit #1), which have sold over 4.5 million copies worldwide. He co-founded Scribe Media, the premier professional publishing company that has helped people like David Goggins, Tiffany Haddish and Dan Sullivan publish their books. He was nominated to the Time Magazine 100 Most Influential List in 2009. He received his BA from the University of Chicago in 1998, and his JD from Duke Law School in 2001. He currently lives on a ranch in Dripping Springs, Texas, with his wife Veronica and five children on a homestead ranch where they raise animals, grow their own food, and create sustainable and redundant systems to be self-sufficient. They also helped start an alternative school with their community. BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post SHOW NOTES (14:30) Consuming content endlessly from media personalities is not all that different to binging soap operas. (22:56) Whether or not you develop type 2 diabetes does depend on genetics, but a huge, often-overlooked factor is how your diet looks. (25:51) To Tucker, Waldorf is the ideal homeschooling curriculum for its heavy emphasis on student-led education. (40:15) "The only reason hospitals aren't cesspools of death is because nurses keep it together." (44:37) True sovereignty over your family's livelihood comes down to owning your own sources of food, water, and power. (50:08) Don't be an oldschool doomsday prepper. Control your inputs. (53:43) Taking responsibility for your livelihood—for your food, water, and power, education, and health—creates a sense of urgency in your life. (1:00:35) The COVID-19 crisis taught Tucker to ask himself the two-part question: "What do I believe and why do I believe it?" (1:11:25) Creating your own society starts with the actions you take. Website I mentioned https://www.sovereignhumans.org/ BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

9 Aug 20231h 23min

Part 198 - Mark Sisson on Health From Your Feet On Up

Part 198 - Mark Sisson on Health From Your Feet On Up

Mark Sisson is a renowned health and fitness expert, author, and entrepreneur, celebrated for pioneering the primal lifestyle movements. Once a competitive endurance athlete who achieved a top-five finish in the Ironman World Championship, he is now a successful businessman who founded Primal Kitchen, a purveyor of paleo-friendly foods and supplements, bought by Kraft Heinz in 2018. In addition to his business ventures, he's a bestselling author, with works like "The Primal Blueprint" that promote ancestral eating and exercise habits for health optimization. Recently, Sisson embarked on a new entrepreneurial journey with his son, Kyle, to create Peluva, a better-for-your-body shoe company. He still produces content on his legendary blog, "Mark's Daily Apple," and is absolutely ripped and supremely healthy despite turning 70 next month. Get 10% off Mark's new shoes https://peluva.com/discount/SAPIEN Video version: https://youtu.be/A3jQXP9y5Uo   BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post   SHOW NOTES:   00:00:00 Introduction to Mark Sisson and his shoe company, Peluva.  00:05:00 Talking about NoseToTail.org and the great products  00:10:00 Sisson's insights on modern running shoes and his journey to designing minimalist shoes.  00:15:00 Emphasis on foot health and the drawbacks of cushioned shoes.  00:20:00 Sisson dispels misconceptions about orthotics, advocates minimalist shoes, and introduces Peluva's Strand model.  00:25:00 Sisson discusses human feet evolution, barefoot experience benefits, and safe transition to minimal shoes.  00:30:00 Importance of toe articulation and foot strength training, promoted through Peluva shoes.  00:35:00 Overview of Peluva's different shoe models and their applications. 00:40:00 Critique of cushioned shoes and the benefits of minimalist footwear for foot mobility.  00:45:00 Sisson talks about the role of walking, exercise, and his personal dietary habits.  00:50:00 Sisson outlines his daily routine, metabolic flexibility, and the value of nutrient-dense diets.  00:55:00 Discussion on caloric value of nutrients, protein-centric diets, and metabolic flexibility.  01:00:00 Closing with Sisson promoting Peluva (use code SAPIEN to get 10% off) and his ambition to globally improve foot health. Get 10% off Mark's new shoes https://peluva.com/discount/SAPIEN   BUY THE MEAT NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post       Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

21 Juni 202357min

Part 197 - Chris Knobbe, MD on Why Seed Oils are The Single Most Harmful Ingredient in the Human Diet

Part 197 - Chris Knobbe, MD on Why Seed Oils are The Single Most Harmful Ingredient in the Human Diet

Chris Knobbe, MD, is a physician, researcher, ophthalmologist, public health advocate, and Associate Clinical Professor Emeritus, formerly of the University of Texas Southwestern Medical Center in Dallas, Texas. Dr. Knobbe is known primarily for his research, publications, and presentations connecting Westernized diets and highly polyunsaturated vegetable oils to numerous chronic diseases, including coronary heart disease, hypertension, stroke, cancers, type 2 diabetes, metabolic syndrome, obesity, Alzheimer's disease, autoimmune diseases, and age-related macular degeneration (AMD). Dr. Knobbe's research has focused greatly on the "vegetable oil hypothesis" as the primary driver of overweight and chronic disease. In 2016, Knobbe formally introduced the hypothesis that processed foods and vegetable oils are the primary drivers of AMD, which is the leading cause of irreversible vision loss and blindness in people over the age of 50, worldwide. GET THE MEAT: http://NosetoTail.org FREE SAPIEN FOOD GUIDE: http://sapien.org SHOW NOTES (3:06) Dr. Chris Knobbe's latest publication: Ancestral Diet Revolution (4:54) How Dr. Knobbe left his ophthalmologist practice in 2015 to pursue the topic of seed oils (6:10) The connection between age-related macular degeneration and diet (12:06) Dr. Chris Knobbes impactful use of data and graphs (14:43) Why are seed oils more concerning than other processed foods? (41:31) Dietary changes in populations across the globe and prevalence of disease- the modern displacement of foods (1:04:49) The effect of sugar vs. vegetable oils on the rate of incidence in the United States (1:18:30): Dietary lipid profile is a determinant of tissue phospholipid fatty acid composition and rate of weight gain in rats (https://pubmed.ncbi.nlm.nih.gov/8463854/) (1:26:40) Seeds oils and poor diet as a driver for cancer (1:34:23) Diet and lifestyle is crucial in determining health outcomes regardless of genetics GET THE MEAT: http://NosetoTail.org FREE SAPIEN FOOD GUIDE: http://sapien.org Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

13 Juni 20231h 34min

Part 196 - Kyle Lasota on Unlocking The Natural Limitless Pill Through Sleep Optimization

Part 196 - Kyle Lasota on Unlocking The Natural Limitless Pill Through Sleep Optimization

On this episode, Brian interviews, Kyle Lasota a Sleep Expert, Biohacker, and YouTuber. Kyle has spent over $150,000 on his own personal health and has helped 1,000's of people transform their sleep. Kyle breaks down exactly how you can start improving your sleep and achieve new levels of performance you previously never had access to. Using these practical biological principles and psychological triggers, he says, anyone can master their sleep. https://www.thesleepadvantage.co/sapien Check out the free video and the course above

25 Maj 20231h 23min

Part 195 - Tara Couture on Incredible Health with the Ultimate Human Lifestyle

Part 195 - Tara Couture on Incredible Health with the Ultimate Human Lifestyle

Tara Couture is one of the most sensational humans the world has to offer. She is a retired Registered Holistic Nutritionist and mother of 3 amazing girls. She and her husband Troy, who works as an ER Doctor, live and manage their homestead farm where they raise and butcher all their own animals. She nourishes her family with nose to tail, regeneratively grown, beyond organic food. Show Notes coming soon!

18 Maj 20231h 30min

Part 194 - Dr. Martin Gorman on The Scary Truth about Sleep Apnea and how to fix it

Part 194 - Dr. Martin Gorman on The Scary Truth about Sleep Apnea and how to fix it

Dr. Martin Gorman, a Bioesthetic trained Dental Practitioner with over 40 years of experience, and very knowledgeable expert in Temporomandibular Joint Dysfunction, Sleep disorders, and epigenetic orthodontics. Dr. Gorman describes his path into the field of sleep-breathing disorders, highlighting the effect of TMJ disorders on optimal airway patency as well as how this relates to breathing disorders, facial appearance, general well-being, and several predominant medical conditions. Website: https://www.mgormandental.com/about/ Key Takeaways (simple version) (00:09) Getting a palate expansion (03:10) Dr. Gorman's journey with Sleep Apnea (06:42) About the jaw expansion work by Steven Lamberg (14:50) The scale of the problem of sleep apnea (20:16) The evolution of sleep tests (26:41) Dr. Gorman's new product that combines expansion and orthodontic treatment. (30:35) How Dr. Gorman's appliance works and its benefits. (35:30) With the rising rate of heart attacks, there is now a scan that can show the level of cholesterol in blood vessels. (42:08) Most diseases have a root cause in sleep, diet, or lifestyle. (48:44) The side of your face that looks bad is the side of your head that did not develop well. (54:25) Comparing the roles of nutrition and physical activity in developing the proper jaw in kids.

4 Maj 20231h 12min

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