Part 32 - Stephan Guyenet, PhD on the Brain Controlling Body Fatness, Your Food Environment, and Low Carb Controversy

Part 32 - Stephan Guyenet, PhD on the Brain Controlling Body Fatness, Your Food Environment, and Low Carb Controversy

Today we're talking to Stephan Guyenet who has a degree in biochemistry and a PhD in neuroscience. He's spent over 12 years in the neuroscience research world studying neurodegenerative disease and the neuroscience of body fatness. He wrote a great book called The Hungry Brain, speaks at conferences, is a Senior Fellow at GiveWell and scientific reviewer for the Examine.com Research Digest.

He is definitely not a low carb person which is why I had him on. He has a lot of great ideas and is a great mind in the space of nutrition. It was very interesting to hear him talk about all the great benefits he did see when he ate a low carb diet 11 years ago. Make sure to listen until the end when he talks about this.

He has some problems with certain people and aspects of the low carb community and is going on Joe Rogan's podcast soon to debate Gary Taubes on his views of the Carbohydrate Insulin theory of obesity and sugar being uniquely toxic

We had some disagreement on the recommended daily allowance of nutrients - he thinks what's recommended is all you need and getting more than that is pointless. I think this is wrong. I think he's basing it on studies of worthless, non-bioavailable vitamin C pills that in excess do nothing. So in that - I agree. I don't think there's any benefit to popping a bunch of these and think we're going to cure a cold. I do know that our ancestors got estimates of 10-20 times the amount of nutrients we get today, so there's a lot more to this discussion that we didn't have time to get into.

We also disagreed on fiber which led to some carnivore talk. He got some things wrong about the member of the Grateful Dead who was a carnivore. He said he died at a young age of a heart attack. I looked into it and it turns out he was carnivore for 48 years and was in excellent health and died in a car accident at 72.

He also says we don't have longterm studies on the safety of low carb diets at the end. This isn't exactly true and furthermore, we have hundreds of thousands of years of human populations living on low carb diets to prove its safety and efficacy. He additionally mentions the low carb community makes crazy claims that aren't based on science. I'm not sure what he's referring to. Not everything can be measured anyway. If tens of thousands of people report to their doctor they aren't hungry anymore, their energy is stable, their brain is working better, they aren't addicted to sugar, they finally have control of their food intake, etc. then this is some great clinical observations and patient anecdotes that add up to a lot.

I think everyone has their own ideas about things and collects info to support their opinion. It's only natural, and I'm sure I'm doing it to, even though I'm trying not to. Everyone has to be in their camp and collect data and narratives to support their theories. He seemed to do this as you'll see throughout the episode.

I agreed with a lot of his points though, especially that humans didn't evolve to eat based on tracking macros and calories and using an excel spreadsheet to figure out what to eat. He's doing great work and looking at this from a different angle which is important. A lot of interesting stuff here so let's get to it. But first I gotta mention the Food Lies film which is in the last stretch of crowdfunding on Indiegogo. We really need your help to finish it. We have a bunch of cool perks like the Eat Meat T-shirt, the movie poster, bonus features, and more. Find it through FoodLies.org or by clicking through this link in the show notes. I really appreciate it - and now here's Stephan Guyenet.

http://indiegogo.com/projects/food-lies-post

Show Notes

  • I'm obsessed with why we get fat and what to do about it and you've been researching this for a long time
  • Why the brain is the most important place to focus on
  • The brain regulates how much we eat, our food choices, and our exercise
  • There's also non conscious processes the brain regulates that influence caloric expenditure, etc.
  • We also study the human genome to find how that plays a role in body fatness
  • When it comes to body weight, the genes that relate the most are in the brain
  • Nobody wants to overeat, but we end up doing it anyway
  • We need to look at our past to understand why we are wired to seek excess calories
  • Animals and hunter gatherers we've studied follow the Optimum Foraging Theory when they acquire food. It's all about the calories per the amount of effort
  • Because we were eating whole foods from nature, if we got enough calories, we by default we're getting all the vitamins and minerals needed
  • They didn't have white flour, sugar, or refined oils
  • We only have receptors for fat, sugar, salt, and glutamate
  • Apparently those are the nutrients that natural selection cared about most to create reward systems for
  • The Hadza people went mainly for meat, tubers, and honey and didn't go for leafy greens
  • The brain is motivated to pursue calorie containing foods, not vitamins and minerals
  • Combining bliss points make certain foods almost irresistible
  • You need to control your food environment
  • Not only don't have it sitting out so you can see certain foods, don't even have them in the house
  • How do genetics play a role? We know it's way more to do with the type of foods eaten
  • About 70% of people in countries like the US are genetically susceptible to become obese when eating the bad diet that exists there. The remaining percent just aren't as susceptible and can get away with it
  • Energy balance while always be a fact, but there's a lot more to it
  • Eat less, move more may work for some people, but it's not how we evolved. It's not a natural way to regulate body weight
  • You can set up a food environment to allow your body to naturally eat the right amount
  • You'd have to be hungry all the time to continue eating processed foods and try to lose weight
  • His definition and thoughts on nutrient density
  • Questioning the necessity of fiber
  • His views on the carnivore diet - he thinks a big factor is becoming lean and it certainly does that
  • He questions if there's long term chronic disease problems that we don't know about
  • Inuit seek some plant matter
  • Sound engineer from the Grateful Dead who was carnivore for 48 years - Stephan said he died of a heart attack at a young age. Turns out he was super healthy and died of a car accident at 72.
  • His book https://justmeat.co/docs/the-bear.pdf
  • They call him "Bear" https://dangerousminds.net/comments/uncle_johns_ham_the_grateful_deads_all-meat_diet
  • Wikipedia on him: https://en.wikipedia.org/wiki/Owsley_Stanley
  • Stephan agrees with what I always say about going to either end of the extreme with super low carb or super low fat you have great benefits
  • He's going on Joe Rogan's podcast to debate Gary Taubes on his views of the Carbohydrate Insulin theory of obesity and sugar being uniquely toxic
  • What happened with Gary Taubes and Dr. Peter Attia's non profit venture NuSI - the Nutritional Science Initiative?
  • What Stephan got wrong in his blog posts
  • Why he thinks Gary Taubes is wrong and what is the evidence
  • He doesn't like the fact that Gary is calling out scientists
  • Exercise and weight loss
  • The model of obesity he subscribes to is that it's all regulated by the brain
  • Homeostatic regulation - hypothalamus controls body fatness like a thermostat
  • The hormone leptin sends feedback to your brain regarding body fat levels
  • Personal fat threshold, how someone can be skinny on the outside but fat on the inside, people can be obese but metabolically healthy, and insulin as a dam holding back fat in the cells
  • He doesn't think that eating an insulin lowering diet like low carb allows you to lose weight because of the lowered insulin
  • He thinks low carb diets and low fat diets work merely because you're taking away the extreme motivation to overeat the foods, AKA hyperplatability
  • Potato hack
  • Metabolic flexibility
  • He thinks being metabolically inflexible is more a sign of insulin resistance than anything
  • He eats about 50% carb, 18% protein, 32% fat
  • He ate a low carb diet after reading Taubes' book Good Calories, Bad Calories 11 years ago
  • He said it was about the same but one benefit was that he wasn't tied to meal times. Eating high carb he definitely knew when it was time to eat. Easier to fast
  • He was easily doing 24 hour fasts. Now on high carb it's way harder and he experiences brain fog
  • Why are low carb diets so maligned in the mainstream media and medical system?
  • What are his solutions for fixing the nation's health problems?
  • His book The Hungry Brain http://www.stephanguyenet.com/thehungrybrain/
  • His website http://www.stephanguyenet.com
  • His Twitter https://twitter.com/whsource

Preorder the film here: http://indiegogo.com/projects/food-lies-post

Film site: http://FoodLies.org

YouTube: https://www.youtube.com/c/FoodLies

Sapien Movement: http://SapienMovement.com

Follow along:

http://twitter.com/FoodLiesOrg

http://instagram.com/food.lies

http://facebook.com/FoodLiesOrg

Theme music by https://kylewardmusic.com/

Avsnitt(233)

Part 224- Boosting Health with Oysters: Conversations on Deep Nutrition with Marine Biologist Stephen Kavanagh

Part 224- Boosting Health with Oysters: Conversations on Deep Nutrition with Marine Biologist Stephen Kavanagh

In this episode of Peak Human, host Brian Sanders delves into a comprehensive discussion with marine biologist Stephen Kavanagh, an expert in shellfish and particularly oysters. Brian and Stephen explore the nutritional benefits of oysters, including their historical significance in human evolution and their roles in promoting testosterone, immunity, and overall health. Stephen details his artisanal processes at his facility in Ireland, emphasizing the purity and nutrient density of oysters used in their products. The conversation expands into broader themes of deep nutrition, the slow food movement, and the importance of returning to nature's ratios in our diets. Listeners also receive insights into the issues surrounding processed foods and modern health epidemics like obesity.    Try the oyster pills! https://nosetotail.org/products/pure-oyster   Show Notes: 02:25 The Journey of Oyster Processing and Supplement Manufacturing 06:02 The Aphrodisiac Effect of Oysters 10:00 Nutritional Benefits and Historical Significance of Oysters 14:18 The Importance of Real Food and Avoiding Processed Foods 15:03 Challenges in the Oyster Industry and Food Lies 20:06 The Synergy of Nutrients and Fortified Foods 26:49 Ancient Diets and the Role of Oysters in Human Evolution 28:48 The Nutritional Power of Oysters 29:41 Evolutionary Benefits of Oysters 31:21 Human Connection to Marine Life 32:17 Oysters and Water Quality 33:01 Oyster Pure: Quality and Testing 34:06 Personal Health Benefits of Oyster Supplements 35:29 Challenges in Marketing Oyster Supplements 43:39 The Slow Food Movement   BEEF TALLOW PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post    Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

31 Juli 56min

Part 223 – Mark Sisson on Metabolic Flexibility, Alcohol, Fiber, and the Real Secrets to Longevity

Part 223 – Mark Sisson on Metabolic Flexibility, Alcohol, Fiber, and the Real Secrets to Longevity

Mark Sisson, 72 and still shredded, returns to Peak Human for a powerful conversation on what real healthspan looks like — not chasing 180 years with futuristic tech, but thriving into your 90s with energy, strength, and vitality. As the founder of the Primal Blueprint, Mark brings decades of wisdom on metabolic flexibility, minimalist training, and practical ancestral living. In this episode, Brian and Mark discuss how to optimize metabolism, how to train smarter (not harder), the real deal with fiber, alcohol, hydration, and carbs — and why metabolic flexibility is the key to enjoying life without strict rules, guilt, or orthorexia. Try the oyster pills! https://nosetotail.org/products/pure-oyster Show Notes: 02:00 The Primal Blueprint and 25 Years of Low Carb Living 04:00 Minimum Effective Dose – Why Mark Hates Overtraining 11:30 Redefining Metabolic Flexibility 14:00 Burning Carbs and Fat – The Joy of Not Being Rigid 18:00 Why Unsustainable Diets Always Fail 20:30 The European Bread Exception – Healing the Gut for Freedom 24:00 Alcohol, Red Wine & the Spectrum of Acceptable Foods 27:30 Fiber is Overrated – Healing IBS with Collagen & Meat 34:00 What Stool Really Is – Busting Fiber Myths 39:00 The Problem with Sugar Diets & Misguided Trends 44:00 You're Not Dehydrated – The Hydration Hype Exposed 49:00 Do We Really Need Electrolytes All the Time? 52:00 Sunlight: Powerful, But Not Without Risk REGENERATIVE PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

23 Juli 1h 6min

Part 222 – Metabolic Freedom, Identity Change & the Myth of Snacking w/ Ben Azadi

Part 222 – Metabolic Freedom, Identity Change & the Myth of Snacking w/ Ben Azadi

Ben Azadi joins Peak Human for a powerful, wide-ranging conversation on what it really takes to reclaim your metabolic health in a world of processed food, misinformation, and identity confusion. As the founder of Keto Kamp and bestselling author of Metabolic Freedom, Ben breaks down the biological and psychological barriers to health—from insulin resistance and the dangers of constant snacking to the mindset shifts required to become someone who actually lives in alignment with vitality and longevity. Host Brian Sanders and Ben dive deep into topics like fasting, hormone signaling, body recomposition, and the power of intention. This episode is as practical as it is inspiring, offering a blend of science, ancestral wisdom, and self-mastery. Try the oyster pills! https://nosetotail.org/products/pure-oyster Show Notes: 01:15 – Meet Ben Azadi: Real food, metabolic freedom, and seed oil awareness 03:10 – The Seed Oil Allergy Card: How to navigate restaurants safely 06:00 – Metabolic Flexibility 101: From sugar burner to fat burner 08:45 – Insulin Resistance is the Root: Why fasting insulin matters more than blood sugar 11:15 – Real vs. Processed Carbs: Potatoes vs. potato chips 13:00 – The Snacking Epidemic: 17 to 23 eating events a day 14:45 – Grazing = Aging: How frequent eating ages you faster 17:30 – mTOR vs. Autophagy: Bodybuilding, aging, and metabolic balance 20:00 – The Hayflick Limit: Cellular aging explained 21:45 – Longevity Mode vs. Growth Mode: Living in cycles 31:15 – Don't Be a Keto Zealot: Even Keto Kamp flexes 36:30 – Nutrient Density Always Wins: Why sugar fasting is not sustainable 40:15 – Metabolic Inflexibility on Both Ends: Fat burners can get stuck too 41:00 – The Diet Culture Trap: Why most diets fail 43:30 – The Subconscious Self-Image: Why your beliefs keep sabotaging you 47:45 – Sticky Note Protocol: The 30-day mental reprogramming 56:30 – Real Food & Movement = Real Results 57:30 – Third World vs. First World: Why simple food wins 58:30 – Final Takeaways: Real food, movement, and mindset still winno REGENERATIVE PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

9 Juli 1h 2min

Part 221 - Easy Fat Loss with Natural Hormone Optimization w/ Chris Kruger

Part 221 - Easy Fat Loss with Natural Hormone Optimization w/ Chris Kruger

Chris Kruger returns to Peak Human for an electrifying, no-nonsense breakdown of why the calorie paradigm is broken, how hormone health is the real foundation of lifelong fitness, and what he calls the "Forever Jeans" formula — a simple, powerful way to track your health without lab work or complex diagnostics. In this episode, host Brian Sanders returns after an eight-month hiatus with an update on his documentary 'Food Lies' and a deep dive conversation with fitness expert Chris Krueger. They discuss the myths surrounding diet and exercise, emphasizing the importance of natural hormone optimization over artificial supplementation like TRT. Krueger outlines a holistic approach to health that targets core strength, mobility, balance, and proper nutrition. The conversation also covers practical, actionable insights for achieving optimal health and fitness without the need for extensive gym workouts or rigid diet plans. The episode concludes with practical tips, such as leveraging whole foods and natural supplements like oyster capsules, to naturally boost essential hormones. Show notes: 00:00 Intro – What's New with Brian Sanders & Food Lies 02:15 Hormone Optimization Over TRT – Why Natural Matters 04:25 The Forever Jeans Formula – Waist-to-Height Ratio Simplified 08:55 Hormones vs. Willpower – Why You're Not Broken, the System Is 14:40 You Don't Need a Gym – The 14-Minute Workout That Changes Lives 21:10 Hunger Means Hunter – Rethinking Hunger, Leptin, and Satiety 28:00 The Leptin Trigger – Why Protein is the Key to Real Satiety 33:00 Snacks Are for Fat Kids? – Fasting, Insulin, and Hormonal Wins 35:00 The Flywheel of Hormonal Momentum vs. the Spiral of Willpower 44:20 How Women Can Optimize Naturally – Fat Loss and the 28-Day Cycle 48:00 The Billionaire with a Heart Attack – A Cautionary Tale 55:00 Helpful vs. Unhelpful Foods – A Simpler Way to Think About Diet 01:02:00 The Fitness Industry's Scam – What Really Works REGENERATIVE PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

18 Juni 1h 22min

Part 220 -  What if Carbs Aren't the Problem? w/ Dr. Randy Johns & Dr. Rob Vasquez

Part 220 - What if Carbs Aren't the Problem? w/ Dr. Randy Johns & Dr. Rob Vasquez

Dr. Rob Vasquez and Dr. Randy Johns, known as The Happy Healthy Guys, wellness experts dedicated to transforming lives through natural health and wellness practices. With a focus on nutrition, detoxification, and holistic living, they aim to empower individuals to achieve optimal health and vitality. Dr. Vasquez and Dr. Johns are passionate about educating others on the importance of a balanced lifestyle, free from toxins and harmful habits. They share their knowledge through online content, public speaking, and wellness programs, helping people across the globe lead happier, healthier lives.   In this podcast episode Dr. Rob and Dr. Randy, share their journey from traditional medical paths to embracing chiropractic care and holistic health approaches. Both doctors recount their personal experiences with health challenges that led them to question the conventional allopathic model, which often focuses on symptom management rather than addressing root causes. Their journey led them to explore various diets and health practices, initially adhering to calorie-restrictive models but eventually shifting towards a more holistic understanding of nutrition. The hosts also discuss their approach to improving metabolic health by addressing common misconceptions and providing practical strategies. They emphasize the importance of metabolic flexibility, explaining how consuming the right types of carbohydrates can actually improve sleep and overall health, contrary to popular low-carb diets. They also talk about the dangers of consuming high-oxalate foods like spinach and almonds, which can lead to serious health issues, including kidney problems. Join their challenge for FREE https://www.h2thinchallenge.com/sapien    Show notes:   [00:02:00] Shift from Allopathic to Chiropractic Care [00:09:00] Trusting the Body's Natural Healing Process [00:11:00] Transition to Nutrition and Metabolism [00:16:00] Evolution of Their Health Philosophy [00:18:00] Rejecting the Calories-in, Calories-out Model [00:20:00] Low Carb Diet Journey,Health Decline and Realization [00:30:00] Reevaluating Dietary Choices [00:37:00] Key Principles for Sustainable Health [00:53:00]High Oxalate foods  [00:55:00] Metabolic flexibility

12 Sep 20241h 19min

Part 219 - Dr. Cate Shanahan on A Root Cause For All Disease?

Part 219 - Dr. Cate Shanahan on A Root Cause For All Disease?

Dr. Cate Shanahan is a board-certified family physician and expert in nutrition, focusing on the intersection of diet and metabolic health. She is the author of Deep Nutrition, The Fatburn Fix, and Dark Calories where she advocates for traditional diets rich in whole foods, emphasizing the benefits of healthy fats and nutrient-dense foods. With a background in biochemistry and genetics, Dr. Shanahan has dedicated her career to understanding how modern processed foods contribute to chronic disease and poor health outcomes. Her work has influenced numerous health professionals and individuals seeking to improve their well-being through dietary changes.

14 Aug 20241h 19min

90 Second Podcast - 3 Amazing Health Transformations

90 Second Podcast - 3 Amazing Health Transformations

Hello everyone, welcome back to Peak Human. This is a different kind of episode. It's going to be three 90 second podcasts. It's my new idea to fill in the gaps between peak human episodes. I do these short episodes with really interesting people I find around the internet with amazing health stories, valuable stuff in 90 seconds, really cool reels. I  put together, put them out on Instagram and also bundle them up and put them out as a little podcast. And so, yeah, in the meantime, go back and listen to the old episodes. Start back at episode one. So many great ones out there. And you may have heard Nose to Tail, my company is not selling meat anymore. We gave it a good run, but there's no profit on real food. I learned how the world works.  The world is the way it is because there's such a high profit margin on processed foods And if you don't have that huge profit margin, it's very hard to stay in business. So we've been supporting our regenerative ranchers here in texas for years now. We're going to sell the last bit of meat this monday We extended it. So if you're listening to this, it's June 12th, we're extending this to Monday, June 17th. And then we're going to stop. But of course we still have our amazing beef tallow body care products, hair, food, skin, food, deodorant, all the things. And we also have our biltong with liver too. We have the sticks made of grass fed meat, made of grass fed beef with liver. Best way to get your organs on the go.  So get that at http://nosetail.org get the last of our pasture raised pork by Monday, June 17th and enjoy the short three podcasts!

12 Juni 20246min

Part 218 - How to Opt Out of the Sickcare System w/ Andy Schoonover

Part 218 - How to Opt Out of the Sickcare System w/ Andy Schoonover

Andy Schoonover is the founder and CEO of CrowdHealth, a company that aims to revolutionize the healthcare payment system through crowdfunding. Schoonover's journey into healthcare innovation was sparked by a personal experience when his daughter needed a simple medical procedure, resulting in an $8,000 bill that their insurance refused to cover. This frustration with the traditional health insurance system led him to create a more transparent and supportive alternative. CrowdHealth operates in all 50 states and offers members a way to manage healthcare costs through a monthly subscription model and crowdfunding for medical expenses. The platform emphasizes transparency, affordability, and personalized support, providing services such as bill negotiation, discounted prescriptions, and access to virtual care. In this episode Andy Schoonover and I talk about the foundation and mission of CrowdHealth, aiming to revolutionize the traditional insurance industry. Schoonover narrates his motivations stemming from personal dissatisfaction with conventional healthcare systems, leading to the creation of an alternative that promotes healthier lifestyles and aligns financial incentives with wise health choices. The discussion broadens to the concept of rationalizing detrimental behaviors by large entities for financial gain, and how such practices negatively impact society's well-being.   Get CrowdHealth for only $99 for the first 3 months with code SAPIEN  JoinCrowdHealth.com   Show notes: 00:12 Introducing Crowd Health: A New Approach to Healthcare 03:58 Building a Parallel Health System: The Crowd Health Mission 01:50 Andy's Journey: From Healthcare Professional to Revolutionizing the Industry 11:59 Navigating the Healthcare System: Personal Stories and Solutions 32:55 Understanding the Root Cause: Lifestyle Changes for Better Health 38:11 Redefining Diet: From Carnivore to Sapien 42:31 Understanding Metabolic Health  43:48 The Slow Danger of Processed Foods 01:00:54 The Spiritual Aspects of Health   REGENERATIVE PRODUCTS: NosetoTail.org Preorder the film here: http://indiegogo.com/projects/food-lies-post   Film site: http://FoodLies.org YouTube: https://www.youtube.com/c/FoodLies   Follow along: http://twitter.com/FoodLiesOrg http://instagram.com/food.lies http://facebook.com/FoodLiesOrg

16 Maj 20241h 12min

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