10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



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• Dave Asprey’s BEYOND Conference: https://beyondconference.com

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• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

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Jeffrey Smith: GMOs & Their Impact on Health - #178

Jeffrey Smith: GMOs & Their Impact on Health - #178

Jeffrey Smith is the founding executive director of The Institute for Responsible Technology, and one of the world’s foremost experts on the dangers of Genetically Modified Organisms (GMOs) and their impact on human health. Jeffrey directed the feature-length documentary, Genetic Roulette, which was awarded the Solari Report 2012 Movie of the Year, and the AwareGuide Transformational Film of the Year. He wrote the world’s best-selling book on GMOs, Seeds of Deception, as well as a book also titled Genetic Roulette, an authoritative work on GMO health dangers. Jeffrey has lectured in nearly 40 countries, has been featured in publications such as the New York Times, Washington Post, LA Times, and Time Magazine, and has appeared on BBC, NPR, and Fox News, among others.   Why you should listen –     Jeffrey comes on Bulletproof Radio to discuss the basics of genetic modification, the unknown effects of genetic engineering, how you can avoid GMOs, and what it will take in order to eliminate the GMO problem from the industry. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Dec 201454min

Dr. Grace Liu: Fixing the Gut Microbiome with Resistant Starch and Probiotics - #177

Dr. Grace Liu: Fixing the Gut Microbiome with Resistant Starch and Probiotics - #177

Dr. Grace Liu is renowned for the information she publishes on the blog, Animal Pharm, under the name “Dr. BG”. She is a Food and Nutritional Scientist and Functional Medicine Practitioner with a doctorate in Pharmacology, and one of the most knowledgeable people on the hot button topics of resistant starch (RS) and its effects on the health of the gut microbiome. She uses her expertise in the pharmaceutical world to explore the various scientific, nutritional, and pharmacological ins and outs of optimal health.   Why you should listen –     Hal comes on Bulletproof Radio to discuss the difference between resistant starch and regular starch, how resistant starch works in the body, how to prioritize the different testing methods for determining gut health, and the things you can do to start fixing your gut immediately. There is tons of in-depth information in this episode. Check out all of the resource links below. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Dec 201457min

Hal Elrod: Be Happier, Healthier, & More Productive - #176

Hal Elrod: Be Happier, Healthier, & More Productive - #176

Please pardon the poor quality of the audio and video, but the information Hal shared was far too valuable not to share!   Hal Elrod is a motivational speaker, success coach, and author of the #1 bestseller, The Miracle Morning. When he was 20, Hal was hit by a drunk driver going 70 mph, and was declared clinically dead for 6 minutes before recovering consciousness. Hal overcame medical logic by bouncing back to not only walk again, but to complete a 52-mile Ultra-marathon. He subsequently went on to become a record-breaking sales rep and national champion sales manager for Cutco, and eventually one of the most sought after keynote speakers in America before becoming a multiple time best-selling author. Hal has appeared on NBC’s Daytime, Fox News, and a host of other TV shows to share his incredible story, and the personal development secrets he has discovered for creating the life of your dreams.   Why you should listen –     Hal comes on Bulletproof Radio to discuss the 5-minute Rule for dealing with adversity, the difference between optimism and realism, the “miraculous” power or positive thought, and the importance of creating an amazing mornings success ritual. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Dec 201454min

Holli Thompson: Hack Into Your Nutritional Style - #175

Holli Thompson: Hack Into Your Nutritional Style - #175

Holli Thompson is the creator of Nutritional Style, a health and nutrition blog and consulting company, and author of the best-selling book, Discover Your Nutritional Style. Holli is a Certified Holistic Health Coach and Certified Natural Health Professional, a Myers Briggs Certified Practitioner, and a regular contributor to renowned health sites Mind Body Green, The Daily Love, and lesscancer.org. She has been featured on ABC’s Let’s Talk Live, on CBS, on The Daily Meal, and in USA Today, and the Huffington Post. Nutritional Style is all about recognizing that food is medicine, and the secret to living life in a beautiful, energized, healthful way. Why you should listen: Holli comes on Bulletproof Radio to discuss the cleansing, how to identify food allergies, the importance of making the connection between he foods you eat and the inflammation they cause, and how to discover your own Nutritional Style. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

28 Nov 201438min

Brad Pilon: Eat Stop Eat & the Fundamentals of Intermittent Fasting - #174

Brad Pilon: Eat Stop Eat & the Fundamentals of Intermittent Fasting - #174

Brad Pilon is the author of Eat Stop Eat, and one of the top experts on the science of fasting, including the widely misunderstood protocol of intermittent fasting. Brad has a Master’s Degree in Applied Human Nutrition, and years of experience in the supplement industry as a Research Analyst and Development Manager. His personal blog, Eat Blog Eat, is a valuable resource for the research on fasting and information for how to optimize and troubleshoot fasting diet protocols, and his workout programs and books are designed to educate people on the truth about how to utilize fasting to achieve the results they want.   Why you should listen –     Brad comes on Bulletproof Radio to discuss the bodybuilder diet myth, the truth about women and intermittent fasting, the role of fasting on your gut microbiome, and why it’s important to understand total biological stress. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25 Nov 20141h 3min

Steven Kotler: Extreme Flow States for Humans & Dogs - #173

Steven Kotler: Extreme Flow States for Humans & Dogs - #173

Steven Kotler is an award-winning journalist and author of multiple New York Times Best-sellers, including The Rise of Superman and Abundance, and co-founder of the Flow Genome Project. Steven is one of the world’s foremost experts on flow states and human performance, and has been featured in leading publications such as TIME, Wired, Forbes, and the New York Times. He also authored A Small Furry Prayer, a book about the relationship between animals and humans that draws on his experience running an animal sanctuary, Rancho de Chihuahua.   Why you should listen –     This is a special in-person interview shot live from the 2014 Bulletproof Conference, where Steven was the keynote speaker! Steven comes on Bulletproof Radio to discuss the evolutionary origins of flow, why running an animal sanctuary helps him in other areas of life, how to trigger flow, and how you can increase performance by conquering fear and facing death. Enjoy the show!   Bulletproof Food Detective Download for iOS   Bulletproof Stress Detective Download for iOS See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

21 Nov 201441min

Pedram Shojai: Origins & Adapting to the New Human Jungle - #172

Pedram Shojai: Origins & Adapting to the New Human Jungle - #172

Pedram Shojai is an acclaimed Doctor of Oriental Medicine, Qi Gong Master, herbalist, acupuncturist, and basically a certified badass. Pedram is an ordained minister in the Taoist tradition of Alchemy, and has studied yoga, meditation, Qi Gong, Tai Chi, Kung Fu, and healing for over 20 years. He uses his vast experience to teach audiences worldwide about philosophy, meditation, Qi Gong, healing, enlightenment, and the esoteric arts. His first documentary, Vitality, was released in 2012, and this year will mark the releases of his newest projects, a documentary called Origins, and a book titled Rise and Shine.   Why you should listen –     This is a special in-person interview shot live from the 2014 Bulletproof Conference! Pedram comes on Bulletproof Radio to discuss the re-calibration of your stress bucket, the importance of consciousness, the double-edged tool of technology, what it means to be a conscious consumer. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Nov 201438min

Dave Kalstein: Mastering the Mind with Neurofeedback and Sayoc Kali - #171

Dave Kalstein: Mastering the Mind with Neurofeedback and Sayoc Kali - #171

Dave Kalstein is the writer and producer of the hit show, NCIS, and an enigmatic bad-ass. On top of writing blockbuster TV episodes, Dave is also an experienced martial artist in the Filipino martial art, Sayoc Kali: The Art of the Blade. He has also done extensive biohacking with heart rate variability, zen meditation, and neurofeedback, and loves to share the enhanced performance that he has found with others.   Why you should listen –     Dave comes on Bulletproof Radio to discuss the his experience with zen meditation and neurofeedback, how the Filipino martial art, Sayoc Kali, has helped him to improve his preparation in all areas of his life, why it is important to find your own form of meditation, and how confronting the unknown can reap great rewards. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14 Nov 201439min

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