PREVIEW Aliquot #6: Genetic and lifestyle risk factors for Alzheimer's disease
The Aliquot Preview25 Helmi 2021

PREVIEW Aliquot #6: Genetic and lifestyle risk factors for Alzheimer's disease

The single most important genetic risk factor for Alzheimer's disease is a variant of apolipoprotein E, or APOE for short, a lipoprotein produced in the liver and brain. Roughly a quarter of all people living in the US – about 75 million people – carry a genetic variant of APOE called APOE4. Having APOE4 is associated with higher circulating levels of LDL cholesterol and an increased risk for Alzheimer's disease. But having APOE4 doesn't mean that Alzheimer's disease is inevitable. In fact, lifestyle behaviors can modulate risk for the disease, too, especially sleep, which provides an opportunity to rid the brain of toxic metabolic byproducts that can contribute to Alzheimer's disease risk. Understanding our genetic risks and addressing lifestyle behaviors – especially our sleep patterns – can influence whether a person eventually develops Alzheimer's disease.

These Aliquot segments feature Dr. Dale Bredesen, a professor of neurology, and Dr. Matthew Walker, a professor of neuroscience and psychology.
  • (00:00) Introduction
  • (02:37) ApoE4 increases Alzheimer's disease risk, but healthy habits can reduce risk (Dale Bredesen discussion)
  • (05:20) People who are ApoE4+ have 2x the risk of having sleep apnea (Matthew Walker segments)
  • (12:03) Glial cells are the sewage system for the brain
You can see the original full interview with Dr. Bredesen You can see the original full interview with Dr. Walker Get more Aliquots! Become a FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, biweekly Science Digest emails, and more. Learn more and sign up at: www.foundmyfitness.com/crowdsponsor

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PREVIEW Aliquot #106: The Science of Longevity Vitamins: Taurine, Ergothioneine, and PQQ

Get more Aliquots! Become an FMF Premium Member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, every-other-week Science Digest emails, and more.   Learn mor...

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PREVIEW Aliquot #78: The minimum effective dose for hypertrophy

PREVIEW Aliquot #78: The minimum effective dose for hypertrophy

Incorporating resistance training into your exercise regimen presents a scheduling dilemma – there's simply not enough time. Performing time-efficient workouts that involve supersets, paired sets, dro...

14 Tammi 202320min

PREVIEW Aliquot #70: Preventing age-related muscle loss

PREVIEW Aliquot #70: Preventing age-related muscle loss

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PREVIEW Aliquot #65: Concerns with chronic NSAID use

PREVIEW Aliquot #65: Concerns with chronic NSAID use

Non-steroidal anti-inflammatory drugs, or NSAIDs, are among the most widely used drugs worldwide, available in both prescription and over-the-counter forms, such as aspirin, ibuprofen, naproxen, and o...

31 Elo 202226min

PREVIEW Aliquot #61: How dietary fiber influences metabolic health

PREVIEW Aliquot #61: How dietary fiber influences metabolic health

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PREVIEW Aliquot #59: How alcohol affects sleep, behavior, and cancer risk

PREVIEW Aliquot #59: How alcohol affects sleep, behavior, and cancer risk

Alcohol, one of the most used drugs worldwide, is a controversial subject. Whereas some research suggests drinking alcohol improves health, an abundance of evidence indicates that drinking alcohol als...

20 Kesä 202232min

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