Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

Jaksot(385)

Episode 294: 293. Should GLP-1 Agonist be Held Prior to Procedure or Surgery?

Episode 294: 293. Should GLP-1 Agonist be Held Prior to Procedure or Surgery?

glucagon-like peptide-1 (GLP-1) receptor agonists can delay gastric emptying, the American Society of Anesthesiologists (ASA) say For patients on daily dosing consider holding GLP-1 agonists on the da...

24 Touko 20245min

Episode 293: 292. An Antibiotic RCT for Community Acquired Pneumonia

Episode 293: 292. An Antibiotic RCT for Community Acquired Pneumonia

But now we have RCT data—278 adults with moderate CAP who were hospitalized (but not in intensive care) to receive either a β-lactam antimicrobial plus clarithromycin or a β-lactam alone. (all patient...

23 Touko 20244min

Episode 292: 291. Does CHATGPT Have a Career In Pathology?

Episode 292: 291. Does CHATGPT Have a Career In Pathology?

AI technology was highly accurate at identifying malignancies and tumor origins — as accurate as senior pathologists, and significantly more accurate than junior pathologists.   Patients with cancer o...

22 Touko 20245min

Episode 291: 290. When Should You Use IV Albumin?

Episode 291: 290. When Should You Use IV Albumin?

HERE IS WHEN IT IS RECOMMENDED TO USE ALBUMIN In patients with cirrhosis and spontaneous bacterial peritonitis, to substantially limit kidney impairment and mortality (low-certainty evidence) THIS IS ...

21 Touko 20246min

Episode 290: 289. Which GLP-1 is the Best Weight Loss Drug?

Episode 290: 289. Which GLP-1 is the Best Weight Loss Drug?

The results for weight loss was  Tirzepatide also known as mounjaro – 8.5 kg  Semaglutide also known as Ozempic -3.1 kg lost Liraglutide aka Victoza – 1.3 kg lostTirzepatide also known as mounjaro – 8...

20 Touko 20245min

Episode 289: 288. An RCT for Time Restricted Eating!

Episode 289: 288. An RCT for Time Restricted Eating!

41 adults (mean age, 59) with obesity (mean weight, 99 kg) and prediabetes or diet-controlled diabetes – everyone got the same diet. Same  micro- and macronutrient composition; same calorie amounts Fo...

17 Touko 20245min

Episode 288: 287. A New FDA Approved Drug for Chronic Rhinosinusitis

Episode 288: 287. A New FDA Approved Drug for Chronic Rhinosinusitis

recipients were more likely than placebo recipients to report much or very much improvement (55% vs. 25%) which isn’t shocking because half of the people were not getting medicinethey also report that...

16 Touko 20248min

Episode 287: 286. Does Hypokalemia cause Heart Badness?

Episode 287: 286. Does Hypokalemia cause Heart Badness?

https://onlinelibrary.wiley.com/doi/10.1111/joim.13757ECG abnormalities were present in 40% of hypokalemic patients and included t-wave flattening/inversion, ST-segment depression, QTc prolongation, l...

15 Touko 20245min

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