Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

Jaksot(385)

Episode 286: 285. Does Exercise Improve Hip OA?

Episode 286: 285. Does Exercise Improve Hip OA?

https://www.acpjournals.org/doi/10.7326/M23-3225researchers randomized 160 patients with mostly unilateral hip OA to two 60-minute sessions weekly for 12 weeks,you were randomized to receive either ne...

14 Touko 20245min

Episode 285: 284. Do Electronic Cigarettes Increase Smoking Cessation?

Episode 285: 284. Do Electronic Cigarettes Increase Smoking Cessation?

adult smokers who are given e-cigarettes are significantly more likely to be abstinent at 6 months from a target quit date with a  (NNT = 8) but those individuals were not more likely to be abstinent ...

13 Touko 20247min

Episode 284: 283. New Guidelines from American College of Cardiology on Atrial Fibrillation

Episode 284: 283. New Guidelines from American College of Cardiology on Atrial Fibrillation

However, screening is not recommended because it has not been shown to improve patient outcomes.. Lifestyle recommendations include moderating alcohol use, quitting smoking, exercising, and losing wei...

9 Touko 20248min

Episode 283: 282. New Guidelines For Management of Acute Pancreatitis

Episode 283: 282. New Guidelines For Management of Acute Pancreatitis

https://journals.lww.com/ajg/fulltext/2024/03000/american_college_of_gastroenterology_guidelines_.14.aspx2 of the 3 following criteria: (i) abdominal pain consistent with the disease, (ii) serum amyla...

3 Touko 20247min

Episode 282: 281. What Do You Do With Elevated Childhood Cholesterol?

Episode 282: 281. What Do You Do With Elevated Childhood Cholesterol?

Bottom line-Elevated cholesterol as a child into an adult is bad but we still don’t know if treating children with medication improves this badness but we can say if you have elevated cholesterol as a...

2 Touko 20246min

Episode 281: 280. How Much Weight Does an Obese Mother Need to Gain?

Episode 281: 280. How Much Weight Does an Obese Mother Need to Gain?

Weight gain <5 kg was not associated with risk for the composite outcome among women with class 1 and 2 obesity (BMIs, ≥30–39.9 kg/m2). Weight gain <5 kg and weight loss were associated with lower ris...

1 Touko 20245min

Episode 280: 279. Does Sitting In a Chair Improve Patient Stay in the Hospital?

Episode 280: 279. Does Sitting In a Chair Improve Patient Stay in the Hospital?

Chair placement was not associated with a difference in patients’ ability to name their physician (P=1.0), ability to successfully identify their reason for hospital admission (P=0.82), or perceptions...

29 Huhti 20247min

Episode 279: 278. Does a Swiss Ball Help During Labor and Delivery?

Episode 279: 278. Does a Swiss Ball Help During Labor and Delivery?

primary outcome was Duration of the first stage of labor was the primary outcome. AND It was 179 minutes shorter (95% CI 146 - 213) in the intervention group than in the control group (392 minutes; st...

26 Huhti 20248min

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