Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

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Episode 182: 182. PART 1 DYSH Out Information on DYSlipidemia, an Evidence Based Approach

Episode 182: 182. PART 1 DYSH Out Information on DYSlipidemia, an Evidence Based Approach

part 1-- you dont get the CME but you get the information

14 Heinä 202123min

Episode 147: Weekly Medical Update 181

Episode 147: Weekly Medical Update 181

PodcastGregory J, Huynh B, Tayler B, et al. High-dose vs standard-dose amoxicillin plus clavulanate for adults with acute sinusitis. A randomized clinical trial. JAMA Network Open 2021;4(3):e212713Stu...

9 Heinä 202120min

Episode 146: Weekly Medical Update 180 (I'm Back)

Episode 146: Weekly Medical Update 180 (I'm Back)

Delay of Pregnancy Among Physicians vs Nonphysicians JAMA Intern Med 2021 May 03;[EPub Ahead of Print], MC Cusimano, NN Baxter, R Sutradhar, E McArthur, JG Ray, AX Garg, S Vigod, AN Simpson It has bee...

30 Kesä 202122min

Weekly Medical Update 179

Weekly Medical Update 179

1) nurses commit more suicide and average population (doctors don't)2) AK will turn in to SCC at a rate of about 2% per year3) STOP SMOKING (even if you gain weight)4) zofran is about equal to the res...

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Weekly Medical Update 178

Weekly Medical Update 178

Donanemab doesn't work for alzheimers if you actually read the study. Mammograms should be done every other year and starting at age 50. Blue-blockers don't prevent eye strain on the computerand sleep...

5 Touko 202123min

Weekly Medical Update 177

Weekly Medical Update 177

CirculationBariatric Surgery and Cardiovascular Outcomes in Patients With Obesity and Cardiovascular Disease: A Population-Based Retrospective Cohort StudyCirculation 2021 Apr 13;143(15)1468-1480, AG ...

29 Huhti 202124min

Weekly Update 176

Weekly Update 176

Compression stocking to prevent cellulitis? NOT SO FAST! Vitamin D still doesn't work even for depression. Hip fractures are on teh decline and it is not because of drugs. A scribe cost money, but how...

20 Huhti 202123min

Weekly Medical Update 175

Weekly Medical Update 175

1- make sure pts follow up on positive FIT test2. symptom severity — driven particularly by catching/locking and clicking/popping — correlated significantly with the burden of cartilage damage. CARTIL...

11 Huhti 20212min

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