Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

Jaksot(385)

174. Gestational Diabetes Screening, DOAC for Valvular Afib, COVID19, Semaglutide

174. Gestational Diabetes Screening, DOAC for Valvular Afib, COVID19, Semaglutide

DOAC are just as safe if not safer for warfarin for valvular afib (NOT valve replacement but moderate to severe mitral stenosis). Please, just give normal lovenox for covid patients. Stop DM drugs in ...

4 Huhti 202121min

173. Uterine Fibroid Symptoms, HPV Vaccine, Copper IUD, Colchicine

173. Uterine Fibroid Symptoms, HPV Vaccine, Copper IUD, Colchicine

Uterine Fibroid and heavy bleeding might have a new drug if your normal drug was giving placebo. HPV Vaccine is still awesome and very very safe. Copper IUD has a new kid in town when it comes to emer...

29 Maalis 202124min

172. Top Articles of 2020 PART 2

172. Top Articles of 2020 PART 2

Part 2 of the top articles of 20201) statins and the nocebo effect2) VA DOD Lipid guidelines- Don't check more than every 10 years!3) blood in the urine and what to do about it per the newest guidelin...

18 Maalis 202132min

Top Published Articles of 2020 part 1

Top Published Articles of 2020 part 1

A two part podcast on the top published articles of 2020

9 Maalis 202121min

Episode 171: 171.  Diabetes Drugs, Statins and Muscle Pain, Vitamin D and COVID, Acne and Food

Episode 171: 171. Diabetes Drugs, Statins and Muscle Pain, Vitamin D and COVID, Acne and Food

SGLT2 inhibitors and GLP1 agonists administered without metformin compared to other glucose‐lowering drugs in patients with type 2 diabetes mellitus to prevent cardiovascular events: A systematic revi...

27 Helmi 202124min

170. Semaglutide, NEW Gonorrhea Guidelines, Cost of Diabetic Drugs, Mask and Children

170. Semaglutide, NEW Gonorrhea Guidelines, Cost of Diabetic Drugs, Mask and Children

Semaglutide works for weight loss but at what co$t? BOARD CHANGER- New gonorrhea guidelinesDiabetes drugs are expensive for our patients and we can't forget that. Children find it hard to tell what fa...

14 Helmi 202119min

169. COVID19, Combined Oral Contraception and DVT, Colon Capsule Endoscopy

169. COVID19, Combined Oral Contraception and DVT, Colon Capsule Endoscopy

Also ask yourself, did this study compare their treatment to the 'gold standard' and if the answer is no they compared it to a straw man, then think big Pharma, or authors that needed publication for ...

10 Helmi 202119min

168. Biden, Buprenorphine, COVID19 Vaccine 95% Effective?

168. Biden, Buprenorphine, COVID19 Vaccine 95% Effective?

The Drug Addiction Treatment Act of Under the Act, physicians may apply for a waiver to prescribe buprenorphine for the treatment of opioid addiction or dependence outside of an opioid treatment progr...

5 Helmi 202127min

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