Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

Episode 311: 310. METHODS MONDAY!! What is a Non-Inferiority Trial

A noninferiority trial is a type of randomized trial that aims to establish if treatmenet X effectiveness is not substantially less than the existing standard. Unlike superiority trials that are designed to show that one treatment is better than another, a non-inferiority trial is designed to show that a new treatment is ‘not unacceptably worse’ than the current standard therapy. You want to see if the drug you are testing is good enough compared to the standard.

Say you wanted tacos from your favorite place across town cause they have the best tacos but there is another taco place that is across the street the tacos are not as good but they are pretty close and it is a 20 second walk not a 20 minute drive. You might quickly in your mind calculate the trade off and say well the place across the street is noninferior.

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66. Zika, Concussion, Hip Surgery, New Guidelines

66. Zika, Concussion, Hip Surgery, New Guidelines

Is Zika as scary as we really think, or is it scarier?! There is a new test for concussion, right? You might wait a day for a hip surgery but don't wait two! Finally, This podcast is sweet but the new...

21 Maalis 201819min

65. A Poor Prognosis of PE, UTI, Smoking

65. A Poor Prognosis of PE, UTI, Smoking

Andrew covers four articles that give a POOR PHYSICIAN PROGNOSIS for the rates of PE, the push for no-antibiotic-UTI, and smoking.

10 Maalis 201819min

61. Joe Is Back To Discuss Three Articles

61. Joe Is Back To Discuss Three Articles

Guess who is back?! Joe joins me on QM and we talk about three recent trials give our thoughts and opinions while we both sip on a Diet Dr. Pepper. It is a quick 20 minutes of us talking out what we a...

4 Helmi 201821min

60. New Format for Questioning Medicine

60. New Format for Questioning Medicine

Turns out when people say, 'You couldn't pay me enough money to quit smoking!' What they meant was "Can you please give me $750?" Kay-x still isn't great. I give my two cents on the hypertension guide...

1 Helmi 201823min

59. DNR Listening to What You Should Watch

59. DNR Listening to What You Should Watch

How good are you at the DNR conversation? It is a conversation we all need to have with our patients no matter the field or specialty of medicine. However, it's a conversation we all avoid like the pl...

8 Joulu 201713min

58. Who pays when they leave AMA?

58. Who pays when they leave AMA?

Does insurance pay? Does the patient pay? What do you think? What do most Doctors think? Is it possible for me to write this entire description in only question form?

1 Joulu 20178min

57. Triple Therapy for AFIB After PCI, Trick or Treat?

57. Triple Therapy for AFIB After PCI, Trick or Treat?

We need to thin out the blood. Afib then to PCI and boom triple therapy. However, I suspect times are changing. It is Halloween and I do my best to play future fortune teller and predict the future in...

1 Marras 201725min

53. How Much Exercise is Just Right?

53. How Much Exercise is Just Right?

We have all heard of Goldilocks when the bed was too hard, too soft, and then just right. A metaphorical description for the J curve of all things in life. Well exercise is no different. Now let's tak...

21 Huhti 201727min

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