198 | Nick Lane on Powering Biology

The origin of life here on Earth was an important and fascinating event, but it was also a long time ago and hasn't left many pieces of direct evidence concerning what actually happened. One set of clues we have comes from processes in current living organisms, especially those processes that seem extremely common. The Krebs cycle, the sequence of reactions that functions as a pathway for energy distribution in aerobic organisms, is such an example. I talk with biochemist about the importance of the Krebs cycle to contemporary biology, as well as its possible significance in understanding the origin of life.

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Nick Lane received his PhD from the Royal Free Hospital Medical School. He is currently a professor of Evolutionary Biochemistry at University College London. He was a founding member of the UCL Consortium for Mitochondrial Research, and is Co-Director of the UCL Centre for Life's Origin and Evolution. He was awarded the 2009 UCL Provost's Venture Research Prize, the 2011 BMC Research Award for Genetics, Genomics, Bioinformatics and Evolution, the 2015 Biochemical Society Award, and the 2016 Royal Society Michael Faraday Prize and Lecture. His new book is Transformer: The Deep Chemistry of Life and Death.


Jaksot(416)

AMA | March 2026

AMA | March 2026

Welcome to the March 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patre...

2 Maalis 3h 53min

345 | Adam Elga on Being Rational in a Very Large Universe

345 | Adam Elga on Being Rational in a Very Large Universe

Behaving rationally involves facing up to conditions of uncertainty; we never navigate the world with perfect confidence. Sometimes we are uncertain about the way the world is, but we can also be unce...

23 Helmi 1h 34min

344 | Adam Gurri on Liberal Democracy and How to Fight For It

344 | Adam Gurri on Liberal Democracy and How to Fight For It

It's possible to look at the course of history over the past few centuries and discern a movement toward increasing democracy, freedom, and individual rights -- "liberalism," in the political-philosop...

16 Helmi 1h 21min

343 | Tom Griffiths on The Laws of Thought

343 | Tom Griffiths on The Laws of Thought

For all that human beings spend a lot of their time thinking, it's far from obvious what that process actually entails. Part of it amounts to classical logical reasoning. But an even bigger part invol...

9 Helmi 1h 19min

AMA | Feb 2026

AMA | Feb 2026

Welcome to the February 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Pa...

2 Helmi 3h 10min

342 | Rachell Powell on Evolutionary Convergence, Morality, and Mind

342 | Rachell Powell on Evolutionary Convergence, Morality, and Mind

Evolution with natural selection involves an intricate mix of the random and the driven. Mutations are essentially random, while selection pressures work to prefer certain outcomes over others. There ...

26 Tammi 1h 37min

341 | Stewart Brand on Maintenance as an Organizing Principle

341 | Stewart Brand on Maintenance as an Organizing Principle

"Things fall apart; the centre cannot hold," wrote W.B. Yeats. I don't know about the centre, but the tendency of things to fall apart is pretty universal, ultimately due to the Second Law of Thermody...

19 Tammi 1h 12min

340 | Rebecca Newberger Goldstein on What Matters and Why It Matters

340 | Rebecca Newberger Goldstein on What Matters and Why It Matters

At any given moment, an uncountable number of events are happening, but only some of them matter to us. What does it mean for something to matter, and more importantly, what does it mean for us to mat...

12 Tammi 1h 18min

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