198 | Nick Lane on Powering Biology

The origin of life here on Earth was an important and fascinating event, but it was also a long time ago and hasn't left many pieces of direct evidence concerning what actually happened. One set of clues we have comes from processes in current living organisms, especially those processes that seem extremely common. The Krebs cycle, the sequence of reactions that functions as a pathway for energy distribution in aerobic organisms, is such an example. I talk with biochemist about the importance of the Krebs cycle to contemporary biology, as well as its possible significance in understanding the origin of life.

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Nick Lane received his PhD from the Royal Free Hospital Medical School. He is currently a professor of Evolutionary Biochemistry at University College London. He was a founding member of the UCL Consortium for Mitochondrial Research, and is Co-Director of the UCL Centre for Life's Origin and Evolution. He was awarded the 2009 UCL Provost's Venture Research Prize, the 2011 BMC Research Award for Genetics, Genomics, Bioinformatics and Evolution, the 2015 Biochemical Society Award, and the 2016 Royal Society Michael Faraday Prize and Lecture. His new book is Transformer: The Deep Chemistry of Life and Death.


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354 | Christian List on Free Will and Levels of Reality

354 | Christian List on Free Will and Levels of Reality

Did I have any freedom in choosing this particular podcast guest? At the level of particles, fields, and the fundamental laws of physics; no. At the level of human agents navigating the world, yes. To...

18 Touko 1h 26min

353 | Alvin Roth on the Economics of Morally Contested Markets

353 | Alvin Roth on the Economics of Morally Contested Markets

Economic markets are efficient ways of deciding fair prices, at least in ideal circumstances of perfect competition, information, and choice. But there is more to life than fair prices. Two people mig...

11 Touko 1h 11min

AMA | May 2026

AMA | May 2026

Welcome to the May 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreon...

4 Touko 4h 6min

352 | Bing Brunton on Connecting the Connectome to the Body

352 | Bing Brunton on Connecting the Connectome to the Body

The connectome is the wiring diagram of a brain, a big matrix that tells us what neurons talk to what other neurons. Understanding it is an important step to understanding how brains work, but a long ...

27 Huhti 1h 14min

351 | Peter Singer on Maximizing Good for All Sentient Creatures

351 | Peter Singer on Maximizing Good for All Sentient Creatures

Peter Singer has been an influential philosopher for a number of decades. He was a significant early voice in animal rights, has been a leading thinker of utilitarianism, and helped inspire the effect...

20 Huhti 1h 15min

350 | J. Eric Oliver on the Self and How to Know It

350 | J. Eric Oliver on the Self and How to Know It

We are more familiar with ourselves than with anything else in the universe, but we generally don't come very close to really understanding what our "self" is. That's not too surprising, as selves are...

13 Huhti 1h 21min

AMA | April 2026

AMA | April 2026

Welcome to the April 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patre...

5 Huhti 3h 46min

349 | Daniel Harlow on What Quantum Gravity Teaches Us About Quantum Mechanics

349 | Daniel Harlow on What Quantum Gravity Teaches Us About Quantum Mechanics

There is something special about gravity. After decades of effort, there is still no convergence on the right way to reconcile Einstein's theory of general relativity with the framework of quantum mec...

30 Maalis 1h 25min

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